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Query: UMLS:C0042373 (vascular disease)
 17,070 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three patients with left atrial myxoma presented with prominent neurologic symptoms and signs (cerebrovascular disease and/or syncope) within the past year. Two patients died because antemortem diagnosis was late or missed. One patient was successfully treated. Cardiac myxoma produces protean clinical manifestations that do not always include cardiac signs and symptoms. Neurologists may be called on for diagnostic consultation in patients who will prove to have cardiac myxoma. Unexplained transient ischemic attacks, cerebral infarction, or syncope (with possible features of seizure activity) are common neurologic manifestations of this disease. Additionally, systemic symptoms, signs, and laboratory data suggestive of collagen vascular disease or vasculitis are also often present. Echocardiography is a dependable noninvasive procedure for a confirmation of diagnosis in suspected cases.
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PMID:Cardiac myxoma: a diagnostic challenge for the neurologist. 98 13

Syncope is usually easily diagnosed, but sometimes it is confused with hypoglycemia, epilepsy, cerebral vascular disease, "drop attacks", hyperventilation attacks, and hysterical faints. Syncope is usually a benign disorder, but sometimes it is a manifestation of a serious neurologic or cardiac disease. This paper provides an approach to the evaluation and management of patients with this disorder.
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PMID:Syncope. 105 1

In extensive studies of cerebral circulation it has been shown that obliterative extracranial vascular disease is associated with a particular regulatory pattern of cerebral circulation. In stenosis of the vertebral artery, of the internal carotid or in the subclavian steal syndrome, cerebral blood flow and O2 consumption was adequate under resting conditions and it is essentially the high cerebrovascular resistance which points to some derangement. The haemodynamic reserves of the brain being restricted, a sudden fall in heart rate may produce a significant decrease in the cerebral blood flow and thus bring about transitory cerebral ischaemic episodes. Twenty patients were studied in whom the production of transitory cerebral attacks was attributable to the coexistence of obliterative extracranial vascular disease and carotid sinus hypersensitivity. Elicitation of the carotid sinus reflex resulted in the production of transitory cerebral ischaemic spells together with a fall in cerebral blood flow in all cases. It is suggested that the transitory cerebral attacks are due in part of the cases to a coexistence of obliterative extracranial vascular disease and carotid sinus syncope. The majority of such patients become symptom-free if bradycardia or sinauricular or av block due to the carotid sinus hypersensitivity can be prevented by atropine therapy or pacemaker implantation.
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PMID:Association of obliterative extracranial vascular disease with carotid sinus hyperaesthesia: a possible mechanism of transitory cerebral ischaemia. 123 49

Although the predominant location of symptomatic carotid artery occlusive disease is the carotid bifurcation, proximal common carotid artery lesions cause similar symptoms. Common carotid artery lesions occur as isolated disease or in tandem with carotid bulb disease. Restoration of carotid artery inflow from subclavian based extraanatomic bypasses should provide adequate reconstruction of these lesions. To evaluate subclavian-carotid artery bypass, a retrospective review of all patients undergoing this procedure from Jan. 1, 1977, to Feb. 20, 1989, was performed. Twenty patients (14 men, 6 women) with a mean age of 60 years were treated. Fifteen patients (75%) were admitted with transient ischemic attacks. Five (25%) had nonfocal symptoms (e.g., dizziness, syncope). Arteriographic evaluation demonstrated severe proximal occlusive disease of the common carotid artery in all cases. Reconstruction bypasses were performed to the carotid bulb (45%), internal carotid artery (30%), and external carotid artery (25%). Four patients underwent endarterectomy of the internal carotid artery in conjunction with subclavian-carotid artery bypass. Bypass conduits included saphenous vein (75%) and prosthetic grafts (25%). Asymptomatic phrenic nerve neuropraxia was identified by postoperative chest radiography in four cases, with no resultant respiratory disease. No perioperative strokes occurred. One postoperative death (5%) resulted from a myocardial infarction. Long-term results were available for 18 patients (90%), with a mean follow-up of 50 months (range, 1 to 122 months). Four patients have died of causes unrelated to carotid vascular disease. Serial duplex scans have documented graft patency in all 18 patients. A single patient returned with focal neurologic symptoms as a result of a posterior circulation infarct.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Extrathoracic carotid reconstruction: the subclavian-carotid artery bypass. 153 Aug 26

Fourteen patients with pulmonary vascular disease, either primary pulmonary hypertension or the result of cardiac defects, underwent balloon atrial septostomy (BAS) over the period of July 1981 to June 1988 because of symptoms of syncope, fatigue, right heart failure, and cardiac arrest. Ages ranged from 4 mo to 50 yr. Two moribund patients died within 24 h of the septostomy due to severe hypoxemia and unrelieved low cardiac output; three others died 2 wk to 35 mo later; the remaining 9 patients have improved symptomatically and are alive 11 to 96 mo after septostomy. One received a heart and lung transplant 19 mo later. We conclude that, in patients with symptomatic cor pulmonale secondary to pulmonary vascular disease, atrial septostomy can improve symptoms and may serve as a palliative bridge to heart and/or lung transplantation.
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PMID:Effects of atrial septostomy in patients with terminal cor pulmonale due to pulmonary vascular disease. 172 34

Of 40 patients with obstructive pulmonary hypertension studied in Basle, Switzerland, during the period 1966-68, 32 had been taking an anorectic drug, aminorex fumarate. Rapidly progressing exertional dyspnoea, central chest pain, and syncope on effort were characteristic features. The absence of the usual causes of pulmonary vascular disease seems to suggest the possibility of drug-induced pulmonary hypertension. Further studies are necessary, however, to clarify the role of aminorex fumarate in this condition.
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PMID:Drug-induced pulmonary hypertension? 510 Apr 97

Although pulmonary hypertension is frequently mentioned as a complication of the sicklemic state, careful review of the medical literature revealed only a single subject in whom cardiac catheterization data substantiated this diagnosis. In two additional patients, both clinical and autopsy findings of pulmonary vascular disease and cor pulmonale were described, although no hemodynamic studies had been performed. We have therefore detailed the clinical history, cardiac catheterization results, and autopsy findings in three previously undescribed patients. These three patients, along with the three case reports culled from the medical literature, from the substance of this review. Pulmonary hypertension should be suspected in patients with sickle hemoglobinopathy in whom either fixed dyspnea or unexplained syncope develops. Early in the course of the disease, right heart catheterization remains the only way to establish the diagnosis with certainty. Noninvasive studies such as chest x-ray, electrocardiography, and echocardiography tend to be nondiagnostic until late in the course of right ventricular failure. Although specific therapy has yet to be defined, the ominous prognosis of this complication of sickle hemoglobinopathy supports the application of experimental modalities such as continuous oxygen therapy, partial exchange transfusion, or even limited phlebotomy.
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PMID:Pulmonary hypertension and cor pulmonale in the sickle hemoglobinopathies. 714 75

To investigate the feasibility of early assessment of preventable disabilities in primary care, we developed a geriatric preventive screening examination with various indicators of physical, emotional, and social functions as well as laboratory exams. Cognitive impairment was measured by the modified MMSE. Severe cases of dementia, who would deserve home visits were excluded. Results of the assessment procedure in 446 patients aged 70 and over (71.5% females) were compared to ratings of general practitioners (n = 67). In these patients we found 4250 medical, 374 psychiatric, and 528 social problems. 45.4% of medical, 61.8% of psychiatric, and 56.8% of social problems where hitherto unknown to the GPs. The prevalence of cognitive impairment was 4.6% according to GPs diagnosis and 21% according to the MMSE. The sensitivity of GPs diagnosis was 14%, the specificity 98%, and the overall agreement measured by kappa was 0.17. There were significant (p < 0.05) associations of cognitive impairment with poor health, vascular disease, syncope, weight loss, previous hospitalization, depression, and ADL and IADL-items. Hypertension, or pathological thyroid function, occurred more frequently in the cognitively impaired (p > 0.05). Only 19.5% of dementia cases had severe functional loss, which substantiates our hypothesis that mild dementia was studied. Of all cases with newly identified cognitive impairment (n = 83 of 446 patients), three (3.6%) had reversible disorder such as depression (n = 1), drug toxicity (n = 2) 3 (3.6%) received counseling, and 5 (6%) further diagnostic assessment or treatment. One (1.2%) patient did not accept any treatment. In the remainder of 71 patients (85.5%), the GPs adopted a wait and see strategy with no intervention. In conclusion, memory deficits seem to be underdiagnosed in general practice despite much treatable comorbidity or social problems, and some reversible conditions such as depression and drug adverse effects.
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PMID:[Early diagnosis and early treatment of cognitive disorders: a study of geriatric screening of an unselected patient population in general practice]. 1043 97

Pulmonary hypertension occurs as a primary or secondary disorder of the pulmonary vasculature. Doppler echocardiography provides a noninvasive tool for the estimation of pulmonary arterial pressure when tricuspid regurgitation or pulmonic insufficiency is present. The cardiology database at Colorado State University was reviewed, and echocardiographic records from cases diagnosed with pulmonary hypertension were evaluated. Application of the modified Bernoulli equation to the maximal instantaneous velocity of a right-sided regurgitant jet provided evidence of pulmonary hypertension in 53 dogs over a 4-year period. Tricuspid regurgitant velocity > or = 2.8 m/second or pulmonic insufficiency velocity > or = 2.2 m/second was considered abnormal and indicative of pulmonary hypertension. Tricuspid regurgitant gradients in 51 dogs ranged from 32 to 145 mm Hg (mean, 63.0 mm Hg; median, 57.0 mm Hg; 25th-75th percentiles, 45.2-76.5 mm Hg). Pulmonic insufficiency gradients in 8 dogs ranged from 20 to 100 mm Hg (mean, 59.5 mm Hg; median, 61.5 mm Hg; 25th-75th percentiles, 32.0-84.5 mm Hg). Affected dogs ranged in age from 2 months to 16 years. Clinical signs were characteristic of cardiopulmonary disease, but a relatively high frequency of syncope was noted (12 of 53 dogs, 23%). Pulmonary hypertension was probably due to increased pulmonary vascular resistance in 23 dogs, pulmonary overcirculation in 2 dogs, and pulmonary venous hypertension in 23 dogs. Five dogs lacked a clinically recognizable cardiopulmonary cause of pulmonary vascular disease. Our results suggest that pulmonary hypertension can occur as a complication of commonly encountered cardiopulmonary diseases, and that Doppler echocardiography can facilitate recognition of this condition.
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PMID:Clinical characteristics of 53 dogs with Doppler-derived evidence of pulmonary hypertension: 1992-1996. 1049 28

Pulmonary hypertension may complicate a variety of congenital or acquired cardiac and pulmonary conditions. This vascular disorder results from conditions that lead to a chronic increase in left atrial pressure, increased pulmonary blood flow, or increased pulmonary vascular resistance. Definitive diagnosis requires cardiac catheterization and detection of systolic and mean pulmonary artery pressures exceeding 30 and 20 mm Hg, respectively. Clinical signs and historical complaints reflect underlying cardiac or pulmonary conditions, although syncope may be a predominant finding. Radiographic changes are nonspecific; however, right ventricular enlargement and enlarged pulmonary arteries should increase suspicion for the disorder. Estimates of pulmonary arterial pressure may be obtained through Doppler echocardiography. This requires detection of a high-velocity regurgitant jet across the tricuspid or pulmonic valve. Further investigation is required to determine how pulmonary hypertension impacts therapy and prognosis for dogs and cats with cardiac and pulmonary diseases.
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PMID:Diagnosis of pulmonary hypertension. 1065 41


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