Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042373 (vascular disease)
 17,070 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Binswanger's type encephalopathy is characterized by progressive dementia and diffuse subcortical ischemic lesions associated with arteriosclerosis. Hypertension is believed to be a major pathogenic factor in causing this encephalopathy but there are some cases of the encephalopathy not suffering from hypertension. In 1985, Yamamura et al. and Fukutake et al. reported familial cases of normotensive juvenile Binswanger's type encephalopathy with alopecia and lumbago, and considered it to be possibly a new clinical syndrome. We reported three cases of relatively young-onset (under the age of 40) Binswanger's type encephalopathy with persistent hypotension. All three patients suffered from neither alopecia nor lumbago. Patient (male aged 40) had repeated episodes of ischemic stroke and had progressive dementia. Patients 2 (male aged 41) and 3 (male aged 34) were not in a state of dementia, but had a history of transient ischemic attacks, and at present are completely symptom-free. Though there were no risk factors for cerebrovascular disease in these cases, the repeated episodes of ischemic stroke and the existence of small multiple lacunes in the basal ganglia on CT and MRI suggest that the white matter damage was principally due to a vascular disorder. In these cases, persistent hypotension was characteristic and might be a factor for the induction and exacerbation of this encephalopathy. These three cases are different from the classic form of Binswanger's type encephalopathy based on hypertension. Normotensive cases have been described before, but our cases do not seem to fall into this category because the blood pressure constantly remained hypotensive.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Binswanger's type encephalopathy without alopecia and lumbago in young hypotensive patients]. 772 96

Patients suffering from vascular disease are often a challenge for the acute pain service. Ischaemia, impaired wound healing, stump and phantom limb pain often require a complex analgesic regimen. Invasive measures such as spinal or epidural catheters can be very helpful but carry the risk of infection, as shown by this case report. A 53-year-old woman with a ten-year history of diabetes developed arterial vascular disease. Her right lower leg had been amputated two years previously. She was now admitted with necroses of the left forefoot. A bypass operation was performed under general anaesthesia. Because of intractable ischaemic pain, she was provided with an epidural catheter by the acute pain service. The bypass occluded, however, and a few days later her left lower leg also had to be amputated, this operation being performed under epidural anaesthesia with bupivacaine. The catheter was subsequently used for postoperative pain control and as a means to prevent phantom limb pain. When signs of superficial catheter infection were noticed days later, the catheter was immediately removed. Intractable pain then developed in the left leg which could not be sufficiently controlled with opioids and NSAIDs, and so a second epidural catheter was inserted one segment rostrally. Several days later the infected vascular prosthesis had to be removed followed by amputation of the thigh, this operation also being performed in epidural anaesthesia. Eleven days after insertion of the first epidural catheter, the patient complained of low back pain and headache. Examination by a neurologist revealed no signs of intraspinal infection. The second epidural catheter dislocated at this point in time and it was decided to introduce a third one, this being the only means to treat the otherwise intractable stump pain. Ten days later meningism, Kernig's sign and leucocytosis developed. NMR tomography detected intraspinal fluid in the epidural space at the dorsal border of the spinal canal. A hemilaminectomy was performed. The spinal epidural space showed signs of inflammation of the adipose tissue, but no pus. A little necrotic material and residues of an old haematoma were removed and the epidural space was lavaged. Specimens taken from the epidural material revealed colonisation with staphylococcus epidermidis, which was sensitive to the broad spectrum antibiotics formerly given to the patient to treat the infection in the left stump. By the next day, all signs of epiduritis had disappeared and the patient recovered completely.
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PMID:[Epiduritis after long-term pain therapy with an epidural catheter--review of the literature with a current case report]. 932 67

Three patients, men aged 62, 57 and 44 years, had suffered for 6-24 months from low back pain, which after an acute moment had worsened with pain radiating to one leg. In all 3 patients, a neurological cause was considered first, but investigations revealed that they had a large abdominal aortic aneurysm (AAA) resulting in emergency surgery. The oldest man died from late complications; the younger men made a good recovery. An AAA should be considered in patients with low back pain and risk factors such as male gender, older age, cigarette smoking, hypertension and previous manifestations of vascular disease. Making the diagnosis as early as possible can be lifesaving.
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PMID:[Back pain? Don't forget the abdomen]. 1521 60

Low back pain, together woth shoulder and neck pain, affect millions of individuals, and is a very usual topic of concern. Frequently is associated with sciatica. Two different low back pain groups are reported: 1--Unspecific low back pain; 2--Organic low bck pain. Unspecific low back pain: two considerations must be present: a) Absence of clinical or radiological signs of concrete disease, and b) Presence of a psychological profile defined by a personality unable to live together with pain. Different pathogenic mechanisms have been invoked to explain the unspecific low back pain: disc herniation irritating the posterior disc ring and the common posterior vertebral ligament, arthritis of small and real--have synovial--, interapophyseal joints, trigger zones of local spasm in the spinal muscles, postural changes after having remained a long time in the same position, and for some few ones, ligament instability in the sacroiliac joint. Organic low back pain: characterized like congenital diseases, acquired diseases--discal herniation, spondylosis, lumbar spine stenosis--, And systemic diseases affecting the spine: aortoiliac chronic vascular disease and abdominal processes causing lumbar and buttocks pain. The therapeutic alternative is either conservative or surgical. Surgery is protagonist in post-traumatic unstale spine, in unstable spondylolisthesis, in spine persistent infections and in spine tumours. Also is subsidiary of surgical treatment the disc degeneration with nerve root irritation causing motor disturbance. The disc degeneration without root irritation precludes conservative management: percutaneous manual nucleotomy, coblation nucleoplasty or back schools programmes, defined like interventions consisting of education and skill programmes supervised by a physical therapist trained in back rehabilitation.
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PMID:[Lumbago and sciatica]. 1950

This paper adopted a series of related analysis methods to comprehensively analyze post-marketing clinical safety data of Shenmai injection from 4,220 cases of SRS and 32,358 cases of multicenter, prospective, registered hospital centralized monitoring in large data background, calculated ADR incidence rate was 0.93 per 1,000, main symptoms of ADR includes chest pain, chills, skin itching, palpitations, fever, nausea, dizziness, vomiting, flushing, numbness, allergic reaction, cyanosis, rash, low back pain, and "breath", "anaphylactoid reaction" and "flush" were the safety warning signals of Shenmai injection. Primary disease for chronic pulmonary heart disease, thyroid disease, and combined with cerebral vascular disease, prior to the injection and continuous use of alprostadil, cyclic adenosine monophosphate, combined with quinolones, penicillins were suspicious influence factors of ADR of Shenmai injection, these promot the clinical safety.
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PMID:[Post-marketing clinical safety assessment of Shenmai injection based on active monitoring and passive monitoring in large data background]. 2724 17