Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042373 (vascular disease)
 17,070 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fibromuscular dysplasia is an increasingly recognized cause of vascular disease in young or middle-aged persons and may be amenable to medical or surgical management. We report five patients, one of whom died, with emphasis on the beaded and irregular pattern of change in the carotid arteries. Neck pain, bruit, and transient ischemic attacks are the most usual clinical symptoms. The cause of fibromuscular dysplasia remains obscure, but in view of the increased incidence in young women, hormonal factors may be involved. Dilation or resection can be considered, as in two patients reported here, and anticoagulation may benefit other patients.
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PMID:Fibromuscular dysplasia. 64 81

Arterial dissection results from bleeding into the vessel wall. Some cases are associated with cervical trauma or have evidence of an underlying vascular disease; many occur without any history of injury or detectable arterial disease. Among the cervical cephalic arteries, the extracranial segment of the internal carotid artery is the vessel most commonly involved; intracranial carotid dissections are much rare. Carotid dissection occurs predominantly in young or middle-aged adults and shows no sex predominance. Although clinical manifestations can be extremely diverse (from isolated headache to rapidly lethal stroke), the most common and suggestive syndrome associates "local" symptoms (such as head or neck pain, Horner's syndrome, pulsatile tinnitus or lower cranial nerves palsy) and delayed (up to several weeks) symptoms of cerebral ischaemia in the territory of the internal carotid artery territory. Dissection can be bilateral or associated with dissection of the vertebral artery. Angiography has long been considered the gold standard for the diagnosis. As this procedure carries a risk of cerebral complications, noninvasive diagnostic approaches such as magnetic resonance imaging and ultrasound have been developed and are increasingly used. The prognosis of carotid dissections depends on the presence and severity of ischaemic brain damage. Recurrent dissections seem extremely rare. Normalization or improvement of the vascular abnormalities during the subsequent weeks is frequent and is an excellent argument in favour of the diagnosis. Although no controlled trial has ever been performed, anticoagulant treatment is often used for a few months when the dissection involves the extracranial segment of the carotid artery. No standard treatment of intracranial carotid dissection has emerged.
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PMID:[Internal carotid artery dissection]. 815 34

Spontaneous internal jugular thrombosis is a rare vascular disorder. It usually occurs as a result of external pressure due to a tumor, infection or as a result of damage to the vessel wall after trauma or central venous catheterization. We report a 35-year-old woman who suffered from severe pulmonary hypertension due to chronic cystic lung disease. She was admitted due to sudden, severe, right-sided neck pain. Internal jugular occlusion by a thrombus was demonstrated by ultrasound and CT-scans but no apparent cause was found. We postulated that the important factors in the development of her thrombosis were stasis due to pulmonary hypertension and high blood viscosity.
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PMID:[Spontaneous internal jugular vein thrombosis complicating chronic pulmonary disease]. 1091 45

Low back pain, together woth shoulder and neck pain, affect millions of individuals, and is a very usual topic of concern. Frequently is associated with sciatica. Two different low back pain groups are reported: 1--Unspecific low back pain; 2--Organic low bck pain. Unspecific low back pain: two considerations must be present: a) Absence of clinical or radiological signs of concrete disease, and b) Presence of a psychological profile defined by a personality unable to live together with pain. Different pathogenic mechanisms have been invoked to explain the unspecific low back pain: disc herniation irritating the posterior disc ring and the common posterior vertebral ligament, arthritis of small and real--have synovial--, interapophyseal joints, trigger zones of local spasm in the spinal muscles, postural changes after having remained a long time in the same position, and for some few ones, ligament instability in the sacroiliac joint. Organic low back pain: characterized like congenital diseases, acquired diseases--discal herniation, spondylosis, lumbar spine stenosis--, And systemic diseases affecting the spine: aortoiliac chronic vascular disease and abdominal processes causing lumbar and buttocks pain. The therapeutic alternative is either conservative or surgical. Surgery is protagonist in post-traumatic unstale spine, in unstable spondylolisthesis, in spine persistent infections and in spine tumours. Also is subsidiary of surgical treatment the disc degeneration with nerve root irritation causing motor disturbance. The disc degeneration without root irritation precludes conservative management: percutaneous manual nucleotomy, coblation nucleoplasty or back schools programmes, defined like interventions consisting of education and skill programmes supervised by a physical therapist trained in back rehabilitation.
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PMID:[Lumbago and sciatica]. 1950

Background. Fibromuscular dysplasia (FMD) is a vascular disease that may present as aneurysms in the cervical arteries. Spontaneous neck hematoma is a rare life threatening medical condition. This is the first report of neck hematoma in a patient with FMD. Methods and Results. We present a case of a 69-year-old woman, with diagnosed cervical FMD and a 3-day history of sore throat and neck pain, who presented with enlarging neck hematoma. No active bleeding was noticed on CT angiography, airway was not compromised, and patient was managed conservatively. Next day, invasive angiography was performed, and no bleeding vessel was demonstrated. Patient has improved and was discharged after 5 days of hospitalization. We have discussed the different etiology of this condition, focusing on systemic vascular diseases. Conclusion. Complaint of neck pain in a patient with a FMD should raise suspicion for possible neck hematoma. Conversely, spontaneous neck hematoma without clear etiology should raise suspicion for a systemic vascular disease.
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PMID:Spontaneous neck hematoma in a patient with fibromuscular dysplasia: a case report and a review of the literature. 2419 Dec 15

The criteria for headache attributed to cervical artery dissection have been changed in the new third edition of the International Classification of Headache Disorders (ICHD-III beta). We have retrospectively investigated 19 patients diagnosed from 2001 to 2006 with cervical artery dissection at onset and followed them up six months after dissection. At dissection onset 17/19 patients were classified as headache probably attributed to vascular disorder at the time of dissection using the ICHD second edition (ICHD-II) criteria. In contrast, 17/19 of patients fulfilled the ICHD-III beta criteria for Headache or facial or neck pain attributed to cervical carotid or vertebral artery dissection or Headache attributed to intracranial arterial dissection. Six months after dissection five of 19 patients still reported persistent headache attributed to dissection. The study demonstrates that the ICHD-III beta criteria for cervical artery dissection are useful for classifying patients at the first encounter. We show for the first time that persistent headache attributed to arterial dissection is frequent.
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PMID:Acute headache and persistent headache attributed to cervical artery dissection: Field testing of ICHD-III beta. 2450 Aug 14