Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042373 (vascular disease)
 17,070 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fifty patients with the clinical diagnosis of initial manifestations of the deficiency of the brain blood supply and 30 normal persons of the corresponding age (the control group) were studied. The main group consisted of patients from 40-67 years. Along with the similar clinical study rheoencephalographic and electroencephalographic studies with the aid of various functional samples were conducted. The initial manifestations of the inadequacy in the brain blood supply frequently developed on the background of cerebral atherosclerosis of a different type of expressiveness, hypertensive disease and their combination, vegetovascular dystonia. With the help of the functional samples the peculiarities of reactivity of the vascular system were established in these patients. The antiorthostatic and nitroglycerin samples appeared to be informative. The combined REG and EEG registrations demonstrated in these patients signs of a deficit of brain blood supply causing in a number of cases changes in its functional states. The clinical (seldom electrographic) changes are of a reversible character and regress during the treatment of the main vascular disease. The obtained data permit to recommend the method of functional electrography (REG and EEG) in order to reveal the initial forms of brain vascular diseases. These patients must be supervised by a dispansary.
 ...
PMID:[Initial manifestations of cerebrovascular insufficiency (clinico-electrographic studies)]. 41 95

A group of patients with athero-arteriosclerotic vascular disease (coronary heart disease and atherosclerosis of the extremities) have been subjected to platelet antiaggregating-antidyslipidaemic treatment with a chlofibrate-dipyridamol association; a control series was treated with chlofibrate alone. Frequency of angina pectoris, pain intensity and trinitrine consumption ware evaluated in patients with coronary heart disease, claudicometry, oscillometry and thermometry in patients with atherosclerosis of the extremities. The following laboratory parameters were also analysed: cholesterolaemia, triglyceridaemia, prothrombin activity, fibrinogenaemia, uricaemia and tolerance of oral glucose loading. Analysis of the results has shown that the association improved the parameters considered in statistically significant fashion; chlofibrate alone led to significant modifications of coronaropathic group parameters (with the exception of pain intensity) whereas it did not lead to significant changes in parameters evaluated for atherosclerosis of the extremities. All laboratory parameters were modified favourably by the association to a statistically greater extent than by chlofibrate alone. Both the association and chlofibrate were well tolerated.
 ...
PMID:[The clofibrate-dipyridamole combination in the treatment of athero-arteriosclerotic vasculopathy]. 43 77

A study of 44 hypertensive patients with unilateral renovascular or renal parenchymal disease is presented. All patients underwent corrective surgery. Out of the 44 operated patients, five did not participate in the follow-up examination. The remaining 39 patients constitute the study population. The effects of surgery on the hypertensive state could be evaluated in 35 patients, whereas four died less than two months after the operation. Follow-up studies were carried out at 8-60 months after the operation. The average period of observation was 32 months; 24 patients were observed for more than two years. As a group, the patients had severe hypertension with extensive target organ damage and widespread atherosclerosis. A fairly rigorous selection process was applied, and an unsatisfactory response to medical management was considered a point of major importance. In the majority of cases, renovascular lesions were atherosclerotic, with only two cases of fibromuscular dysplasia. Unilateral nephrectomy was performed in 32 patients, whereas seven underwent reconstructive vascular surgery. Out of 35 patients, 22 (63%) were cured, 8 (23%) improved and 5 (14%) unaltered. A gratifying regression of hypertensive lesions in target organs was observed in patients who were cured or improved by surgery. The frequency and severity of postoperative complications were related to the presence of extrarenal vascular disease.
 ...
PMID:A follow-up study of hypertensive patients after operative treatment of unilateral renovascular or renal disease. 47 83

To assess the role of serum factors in the genesis of accelerated vascular disease in chronic renal failure, human arterial smooth muscle cells (SMC) and dermal fibroblasts were grown in culture and the effects of serum from chronic dialysis patients on cell proliferation was studied. Exposure to serum from these renal failure patients was associated with significantly greater growth of both SMC and fibroblasts than that observed with control serum. A portion of this mitogenic effect appears to be related to the presence of a factor(s) which is heat stable, dialysable, and is contained in the lipoprotein deficient fraction of plasma of density greater than 1.25 g/dl. These findings suggest that circulating substances which stimulate the proliferation of SMC may contribute to accelerated cardiovascular disease in patients undergoing chronic dialysis treatment.
Atherosclerosis 1979 Nov
PMID:Chronic renal failure and atherogenesis--Serum factors stimulate the proliferation of human arterial smooth muscle cells. 51 37

Platelets play an important role in atherogenesis. This has given rise to the speculation that inhibitors of platelet function may prevent atherosclerotic changes. Two distinct therapeutic goals might be achieved by the use of inhibitors of platelet function in vascular disease - one, the prevention of thrombosis and, two, the prevention of atherosclerosis. The choice of inhibitor may well determine the goal achieved. Thus far, the data available indicate that inhibitors of platelet aggregation, such as aspirin, are the most effective in the prevention of thrombosis, while inhibitors of platelet adherence, such as dipyridamole, are likely to be the most effective in the prevention of atherosclerosis.
 ...
PMID:Inhibitors of platelet function and atherogenesis. 52 33

All the cases of spontaneous intracerebral hemorrhage that were autopsied between 1965 and 1976 at at Kuakini Hospital, Hawaii, were analyzed to determine the frequency of coexistent cerebral congophilic angiopathy. Seven of 75 cases (9.3%) were confirmed to have deposition of amyloid in the intracerebral vessels by means of polarized light microscopy and electron microscopy. The cerebral congophilic angiopathy was found to have predilection for aged patients and women (ratio of 6:1). Diabetes mellitus, hypertension, atherosclerosis, systemic amyloidosis, and paraproteinemia did not appear to be associated with this change. There is, however, a strong correlation between classic as well as compact senile plaques and this vascular lesion.
 ...
PMID:Congophilic angiopathy and cerebral hemorrhage. 58 Jul 26

Nine patients with atherosclerotic carotid artery disease associated with neck radiation were compared to 40 control patients. The data suggest that significant differences in age, incidence of coronary and peripheral vascular disease, elevated lipids and serum cholesterol, and the angiographic incidence of disseminated atherosclerosis justify the description of radiation-induced carotid disease as a clinical entity. Elevated serum cholesterol and hyperlipidemia may contribute to the development of radiation-induced vascular disease. Successful surgical reconstruction does not appear to be influenced by the prior radiotherapy, although periarterial fibrosis and increased difficulty in separating the plaques from the vascular media was encountered.
 ...
PMID:Radiation-induced carotid artery disease. 62 23

The author conducted a morphological analysis of 8 cases (from 61--83 years old) with extensive subarachnoidoparenchymatous hemorrhages, accompanied by expressed congofil angiopathy in different clinical processes. In 5 cases congofil angiopathy was the only lesion of cerebral vessels, in 3 cases it was combined with hypertensive angiography and atherosclerosis. In the latter cases the morphological picture was characterized by a great diversity due to greater expressiveness of accompanying hyalinosis and proliferative changes in the walls of the vessels. In both subgroups all the changes were prevalently in the meningocortical vessels. The author points to frequent relapses of the process.
 ...
PMID:[Role of congophilis angiopathy in the genesis of subarachnoid--parenchymatous hemorrhages in middle-aged and elderly persons]. 62 44

The authors study the alterations of the senile brain: cerebral atrophy due to neuronal loss, degenerative alterations of neurons, and vascular and ischemic alterations, including atherosclerosis, amyloid angiopathy, and lacunae.
 ...
PMID:[Lesions in senile brain: an anatomic study (author's transl)]. 74 Jan 70

Atherosclerosis in renal allograft recipients necessitated modification of vascular anastomoses in 62 per cent of patients older than forty years in contrast with 10 per cent in younger patients. Three forms of vascular disease occurred: atherosclerotic occlusion, tortuosity of vessels, and disruption of plaques by vascular clamps. Successful modifications of the procedure and avoidance of ischemic graft injury are described including relocation of the transplanted ureter.
 ...
PMID:Technical considerations in elderly renal allograft recipients. 78 54


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>