Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042373 (vascular disease)
 17,070 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mice of the autoimmune strain MRL/1, the congenic strain MRL/n, and two control strains, Balb/c and C57BL/6 mice, were fed diets which varied in the content of lipid and cholesterol. Serum cholesterol levels were highest in mice fed diets containing cholesterol and lowest in mice fed laboratory "chow." Animals fed diets that increased serum cholesterol had decreased production of prostacyclin by vascular tissue and increased production of thromboxane A2 by platelets. Prostacyclin production by heart tissue in response to arachidonic acid showed a negative correlation (r = -0.86) with serum cholesterol. In contrast, serum thromboxane demonstrated a positive correlation (r = 0.70) with serum cholesterol. The prevalence of autoimmune vasculitis seen in MRL/lpr mice was not affected by diet. However, MRL/lpr mice fed a high-fat, cholesterol-containing diet had intimal vascular lesions containing foam cells typical of arteriosclerosis. It is suggested that diets that raise serum cholesterol may influence the nature of autoimmune-mediated vascular disease by altering the balance between thromboxane and prostacyclin.
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PMID:Effects of nutrition of disease and life span. II. Vascular disease, serum cholesterol, serum thromboxane, and heart-produced prostacyclin in MRL mice. 638 25

Incidence of peptic ulcers in hospitalized patients with arterial occlusive disease without history or clinical symptoms of ulcer disease was 32% and four times higher than in patients with acute phlebothrombosis. Possible etiological factors could be: decreased blood perfusion of gastric or duodenal mucosa because of generalized arteriosclerosis, intake of ulcerogenic drugs, chronic abuse of nicotine, and stress due to the underlying arterial occlusive disease. Patients with inflammatory vascular disease are affected as often as are patients with arteriosclerotic disease. Routine endoscopic examination of the upper GI-tract should be performed in such patients in order to exclude potential bleeding sources before treatment with fibrinogen lowering drugs is started.
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PMID:[Incidence of peptic ulcer in an inpatient angiologic patient sample]. 648 41

The question as to whether a specific behavior or type A pattern is limited to patients with coronary artery disease, or is found in atherosclerotic disease, in general, is explored. The interrelationship between a pattern of "pressured" behavior, assessed by open ended interviews, type A behavior, determined by the Bortner test, and peripheral atherosclerotic disease was investigated in a controlled retrospective study which compared three groups of 13 patients each: intermittent claudication (IC), intermittent claudication combined with coronary artery disease (CADIC) and a control group of patients without vascular disease (WVD). A pressured behavior pattern, assessed by interview, was found to be most prominent in the CADIC group, and least in the control group. The subjects with arteriovascular disease tended to exert more control over people compared to the WVD patients (Fisher's exact probability test, p = 0.05). The tendency to type A behavior, measured by means of the Bortner scale, also differentiated the three groups with CADIC scoring highest and WVD scoring lowest (analysis of variance, F = 3.944, p less than 0.05). IC patients present personality features of proneness to coronary disease. The pattern of "pressured" and type A behavior seem to correlate with the number of vascular areas involved in atherosclerotic disease.
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PMID:Pressured pattern or type A behavior in patients with peripheral arteriovascular disease: controlled retrospective exploratory study. 661 98

Navicular bones from 74 horses were examined at necropsy. Animals ranged in age from eight months to 30 years. Eight horses had a clinical history of navicular disease. Degenerative lesions in the fibrocartilaginous surface of the navicular bone and of the surface of the deep flexor tendons were age related changes not necessarily related to lameness. These lesions were more extensive in horses with a history of navicular disease, and were often accompanied by adhesions and subchondral cavitation of the fibrocartilaginous surface of the navicular bone. Osteophytes, present in 12 of the 74 horses, appeared to be age-related and were uncommon in horses with a history of navicular disease. Nutrient foramina on the distal border of the navicular bone were highly variable in size and shape; in horses with a history of navicular disease they often had a small external opening that became larger as it penetrated the bone. Occlusive vascular disease (arteriosclerosis) was found in sound horses and in horses with a history of navicular disease. Thrombosis of arteries or ischemic necrosis of bone was not identified in any case.
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PMID:Pathological changes in the navicular bone and associated structures of the horse. 666 28

A study was carried out of 302 major amputations for vascular insufficiency in the lower limb with respect to levels of amputation, postoperative revisions, re-amputations on a higher level and postoperative mortality. This information was related to vascular disease (diabetes mellitus/arteriosclerosis) and to the experience of the surgeon. There was a high incidence of above-knee amputations both of diabetics and arteriosclerotics and the rate of complications was high for "senior" as well as "junior" surgeons. The amputations were performed during 1978 and the study has shown that there is an urgent need to lower the level of amputation without increasing the rate of complications. The study indicates that there is a need for further information about the problems involved in rehabilitation of above-knee amputees.
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PMID:Amputations for vascular insufficiency. 685 55

It is known that in autopsies severe arteriosclerosis and myocardial infarction are less frequently associated with liver cirrhoses and carcinomas (except bronchial carcinoma) than with other cases. This does not mean that liver cirrhosis and carcinoma protect from vascular diseases, but the higher mortality rate if liver cirrhoses, carcinomas, and vascular diseases plays an essential role and most be taken into consideration, when conclusions concerning biological connections shall be drawn from autopsy-statistical examinations. In a certain age group, e.g. in males aged 50, in the autopsy material severe arterioscleroses are more frequent than in the living population of the same age, since the death rate (number of deceased patients as related to the total number of patients) is high for cases with circulatory diseases and vascular diseases, respectively. Liver cirrhoses, carcinomas (also with high death rates), and other diseases causing death come from the total living population with healthier (less changed) vessels and, therefore, of course they must be less frequently combined with severe arteriosclerosis and myocardial infarction than the total number of death cases, for which the distribution of arteriosclerosis in all death cases is essentially determined by the number of patients who died from the sequelae of a vascular disease. The correctness of this consideration is mathematically proved by a simple model example.
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PMID:[Coincidence and biological association of diseases in autopsy findings]. 688 Apr 43

The clinical histories, risk factors, and autopsy findings were reviewed for five deceased hemophiliacs over the age of 40 years to determine the prevalence and severity of arteriosclerosis. The presence of a severe, congenital, hypocoagulative state did not prevent these five men from displaying typical arteriosclerotic vascular disease. One patient actually died of severe, multivessel, coronary artery disease.
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PMID:Arteriosclerosis in severe hemophilia. A postmortem study. 689 53

Red cell flexibility (RCF) was studied in 40 patients with severe occlusive arterio-sclerotic disease of the lower extremities (Group I) and in 17 patients with aortic or mitral valve prosthesis (Group II). RCF was studied in terms of rigidity and fragility using a filtration method. Pentoxifylline, which according to our previous observations increases the flexibility of red cells in healthy subjects, also markedly improved RCF in Group I, particularly in terms of fragility. The pentoxifylline-induced increase in RCF was less marked in Group II; only the rigidity parameter was significantly decreased. Reid et al [11] reported decreased deformability of red cells in patients with intermittent claudication. Since then a few other studies have been published, in which decreased red cell flexibility (RCF) was observed in patients with diabetic vascular disease [1, 4, 9, 12] and cerebral arteriosclerosis [10]. The objective of this study was to compare RCF in patients with widespread arteriosclerosis and heart valve prosthesis, the latter condition inducing a 'pure' mechanical red cell injury. Both patient groups were also studied after the administration of pentoxifylline, a drug known to improve the flexibility of normal red cells--see [6].
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PMID:Effect of pentoxifylline on red cell flexibility in arterio-sclerotic patients and in patients with heart valve prosthesis. 694 93

Nonarteriosclerotic (virgin) and arteriosclerotic (breeder) rats were made diabetic with alloxan. Animals were treated with constantly adjusted doses of insulin, occasionally adjusted doses, or no treatment. The obese breeder rats lost weight; the lean virgin rats gained weight. All of the animals were autopsied 5 months post-alloxan. Blood pressure increased in virgin rats; the pre-existent mildly elevated blood pressure of arteriosclerotic breeder rats decreased. Glucosuria was effectively reduced in animals accorded good control; blood glucose was not effectively controlled. Circulating nonesterified fatty acids and triglycerides were more effectively normalised by insulin therapy. The diabetes was accompanied by adrenal hypertrophy, thymus gland involution, and increased circulating corticosterone. Virgin rats (68%) developed arterial disease when made alloxan-diabetic; treatment with insulin completely prevented arterial disease. Breeder rats with pre-existent arteriosclerosis showing worsening of their cardiovascular disease; when made severely diabetic those provided with good control of their diabetes were protected against exacerbation of their vascular disease.
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PMID:Good versus moderate regulation of alloxan-induced diabetes in arteriosclerotic and nonarteriosclerotic rats. 699 26

Lipoprotein compositional studies were carried out in 20 patients with atherosclerotic peripheral vascular disease. Twelve of these patients were normolipidemic, the other eight, hypertriglyceridemic. Ten normolipidemic and 10 hypertriglyceridemic age-matched subjects were used as controls. High density lipoprotein cholesterol levels were markedly reduced in the hypertriglyceridemic subjects, both with (35.1 +/- 5.0 mg/dl) and without (36.2 +/- 11.7 mg/dl) peripheral vascular disease, as compared to the normolipidemic patients (47.0 +/- 6.3 mg/dl) and controls (48.1 +/- 10.0 mg/dl). A decreased relative content of apo C-11 in very low density lipoproteins in the hypertriglyceridemic subjects, as compared to the normolipidemics, was detected by isoelectric focusing. Hypertriglyceridemia in patients with peripheral vascular disease shows a typical Type IV lipoprotein and apoprotein profile. Apoprotein B levels in very and low density lipoproteins were determined by electroimmunodiffusion and selective precipitation with tetramethylurea (r = 0.981 between the two methods). All the patients with peripheral vascular disease showed an increased apo B content in very low density lipoproteins vascular disease showed an increased apo B content in very low density lipoproteins (VLDL) as compared to controls (apo B cholesterol in VLDL = 0.341 +/- 0.124 for peripheral vascular disease patients and 0.236 +/- 0.086 for controls, p less than 0.001). A significant correlation between VLDL cholesterol and apo b levels was detected both in peripheral vascular disease patients and in controls; however, two distinct populations could be clearly separated (slopes of the regression lines: peripheral vascular disease patients = 0.350; controls = 0.215, p less than 0.001). The data suggest a possible discriminatory power of VLDL-apo B levels in patients with peripheral vascular disease independent from other lipoprotein and lipid parameters.
Arteriosclerosis
PMID:Increased apoprotein B in very low density lipoproteins of patients with peripheral vascular disease. 705 24


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