Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A type I cryoglobulinaemia associated with cold-induced urticaria was demonstrated in a 64-year-old woman without primary disease. The cryoglobulin contained only IgG lambda as disclosed by immunofixation technique. Different physicochemical studies indicated that the IgG lambda component was monomeric at temperatures above 35 degrees C, but became polymerized below 35 degrees C. In addition crossed immunoelectrophoresis of plasma fibronectin from the patient showed a heterogeneous precipitate at low temperatures but a homogeneous precipitate at 25 degrees C indicating a complex formation at low temperature between IgG lambda and fibronectin. Fibronectin, however, was not essential for the cold precipitation of the cryoglobulin. The precipitation phenomenon at low temperatures was found to be a result of the physicochemical properties of the cryoglobulin itself unrelated to the antibody specificities tested. The importance of performing the immunochemical and physicochemical techniques at low temperature (7 degrees C) and at high temperature (35 degrees C) to gain knowledge of the nature of the protein, is emphasized. We conclude that only results obtained by relevant laboratory procedures might lead to correct classification and understanding of cryoglobulinaemia.
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PMID:Immunochemical studies on an IgG lambda cryoglobulin in cold-induced urticaria. 642 2

Biochemical cryoproteins are divided in cryoglobulins (type I-III), plasma-cryoproteins (heparin precipitable factor, cryofibrinogen and cryofibrin), and fibronectin. While cryoglobulinemias and plasma-cryoproteinemias are mainly caused by internal diseases, fibronectin may be a physiological substance. Because of skin lesions as purpura, necrosis or cold urticaria the patients rather often consult dermatologists at first. Furthermore arthralgias, kidney diseases, neurologic symptoms and lung involvement can be observed. For diagnosis a accelerated blood sedimentation rate at 37 degrees C and a decelerated at 4 degrees C is helpful. By further investigations underlying internal diseases have to be disclosed. In the therapeutical efforts the treatment of the underlying diseases is most important. Additional plasmapheresis and immunsuppressive treatment may be successful.
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PMID:[Cryoproteinemias]. 700 93