Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0042109 (
urticaria
)
6,569
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cyclophosphamide is an important immunosuppressive agent in the treatment of many rheumatic diseases.
Urticaria
and anaphylaxis to intravenous cyclophosphamide (i.v.
CYC
) have been reported in patients with haematological and solid organ malignancies. This is the first report in the rheumatology literature of a type I hypersensitivity reaction following monthly i.v.
CYC
. An 18-year-old girl with systemic lupus erythematosus (SLE) developed generalized
urticaria
(without concomitant angioedema or anaphylaxis) following i.v.
CYC
. She had previously developed life-threatening angioedema following a respiratory tract infection. She successfully completed regular pulse i.v.
CYC
with pre-medication with anti-histamine. In the absence of a severe type I hypersensitivity reaction and other suitable immunosuppressive agents, i.v.
CYC
may be safely continued with pre-medication and careful monitoring during each infusion.
...
PMID:Cyclophosphamide type I hypersensitivity in systemic lupus erythematosus. 1195 77
