Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Intravascularly administered lower-osmolality contrast media cause fewer adverse effects than do higher-osmolality media. Immediate generalized reactions such as acute urticaria or bronchospasm have been documented occasionally in patients receiving lower-osmolality contrast media. To our knowledge, this is the first reported case of an immediate generalized reaction to a lower-osmolality contrast medium in which significant hypotension also occurred. During cardiac catheterization, in a patient who had never been exposed to a contrast medium, a 69-year old man developed chest tightness, periorbital and facial edema, slight uvular edema, and a decline in blood pressure from 150/71 to 97/67 mm Hg. Epinephrine hydrochloride, diphenhydramine hydrochloride, and hydrocortisone were administered. The lack of absolute safety of lower-osmolality contrast media emphasizes the need for clinical awareness and availability of emergency therapy when these agents are utilized.
Arch Intern Med 1987 Dec
PMID:An immediate generalized reaction to iopamidol. 368 72

Allergy to potato is uncommon, and even more uncommon is allergy to potato pollen. The occurrence of both phenomena in the same patient made it possible to study cross-reactivity patterns of potato antigens. An 11-year-old girl, exclusively breast-fed for her first 4 months, developed anaphylactic symptoms after ingestion of potato at 5 months of age when she was fed potato for the first time. Subsequently, she developed urticaria, angioedema, and respiratory and systemic symptoms on contact with potatoes, ingestion of potatoes, and exposure to cooking potatoes or potato pollen. Three allergenic extracts from potato pulp, peel, and pollen were prepared. Polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate and isoelectrofocusing of the three extracts were performed. IgE-mediated allergy to these extracts was demonstrated by means of immediate skin test reactivity, positive passive transfer, RAST, RAST inhibition, and leukocyte histamine release. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the pulp extract followed by electroblotting and autoradiography demonstrated specific IgE antibodies directed against several proteins ranging from 14,000 to 40,000 daltons.
J Allergy Clin Immunol 1986 Dec
PMID:Allergy to white potato. 378 75

The correct diagnosis and characterization of C1-inhibitor deficiency depends on both clinical observations and laboratory evaluation of complement in plasma. Rocket immunoelectrophoresis for C4d is a sensitive assay for C4 activation in plasma. We have evaluated the value of this assay in identifying patients with C1-inhibitor deficiency. C4 activation was assessed in the plasmas of 15 patients with hereditary angioedema, five patients with variant form of hereditary angioedema, and four patients with acquired C1-inhibitor deficiency. Control groups consisted of 27 patients with chronic idiopathic urticaria and/or angioedema and seven normal volunteers. C4 activation was detected in all 52 plasma samples collected from the 24 patients with C1-inhibitor deficiency. The degree of C4 activation increased during attacks of angioedema and decreased (but remained elevated) during treatment with attenuated androgens. The concentrations of C4, C2, and C1 inhibitor were also measured; however, none of these measurements identified all of the patients with C1-inhibitor deficiency. Thus, we conclude that the measurement of C4 activation is one of the best tests available to evaluate a patient for C1-inhibitor deficiency, and a normal result will exclude the diagnosis of C1-inhibitor deficiency.
J Allergy Clin Immunol 1986 Dec
PMID:The value of rocket immunoelectrophoresis for C4 activation in the evaluation of patients with angioedema or C1-inhibitor deficiency. 378 76

We report two sisters who both have had severe attacks of urticaria and angioedema only when taking the contraceptive pill and during the latter half of pregnancy. Although they exhibited many features in common with hereditary angioedema (HAO), the C1 esterase inhibitor levels and other complement components were consistently normal, including levels measured during pregnancy and at the height of the eruption after oestrogen challenge. Aetiological factors in relation to other patterns and causes of urticaria are discussed.
Br J Dermatol 1986 Dec
PMID:Recurrent angioedema: familial and oestrogen-induced. 380 12

Eleven patients with primary acquired cold-induced urticaria were treated with ketotifen (1 mg b.i.d.) or placebo in a double-blind, crossover design trial. After seven days of ketotifen treatment, reaction times to a cold stimulus were significantly delayed in ten of the 11 subjects. No effect was seen after placebo treatment. It is concluded that ketotifen may have a place in the treatment of primary acquired cold urticaria.
Ann Allergy 1985 Dec
PMID:Effect of ketotifen treatment on cold-induced urticaria. 390 25

A case of systemic mastocytosis is reported with an observation period of 20 years. During these two decades multiple manifestations of the disease appeared including urticaria pigmentosis, episodic histamine release, gastro-intestinal involvement and hepatosplenomegaly. The most extraordinary, and possibly unique phenomenon, has been the development of a massive proliferation of large mastocytomas mainly, but not exclusively, limited to the lower extremities. For different reasons (mechanical disability, bleeding, cosmesis), these tumors have required repeated admissions for surgical removal. The most successful technique has involved use of the ultrasonic scalpel.
J Surg Oncol 1985 Dec
PMID:Systemic mastocytosis with extensive large cutaneous mastocytomas: surgical management. 393 76

Terfenadine, a potent and non-sedative antihistamine, was shown to be effective in chronic idiopathic urticaria in a double-blind crossover placebo controlled trial. An oral twice daily 60 mg dose of terfenadine was given and itch and wheal parameters were assessed daily. Despite the overall effectiveness of terfenadine, a variable response was noted which was similar to that shown in previous studies with other antihistamines.
Br J Clin Pharmacol 1985 Dec
PMID:Terfenadine and placebo compared in the treatment of chronic idiopathic urticaria: a randomised double-blind study. 393 49

Bee venom allergy is a common problem in South Africa, and although most patients develop only local reactions after a sting, generalized life-threatening reactions may occur. Immunotherapy with purified bee venom has proved effective in preventing subsequent sting anaphylaxis. However, because of side-effects during a course of desensitization, the high cost of this form of therapy and the extended period for which therapy may be required, careful patient selection is essential. Only patients with documented generalized reactions should be considered for therapy. Patients with severe local reactions, and those with urticaria or other cutaneous symptoms, should not undergo desensitization. Although it is not yet known for how long desensitization should continue, a negative skin test 3-6 years after the initiation of therapy suggests that desensitization can be discontinued.
S Afr Med J 1985 Dec 07
PMID:Desensitization of patients with bee venom allergy--current status. 407 39

Photobiological tests were carried out on a 32-year-old man who suffered from porphyria cutanea tarda (PCT). The patient developed an immediate type of skin reaction with erythema and whealing following monochromatic irradiation at 400 nm, but did not have any abnormal immediate skin reaction after exposure to natural sunlight. Pre- or simultaneous irradiation with visible light, wavelength greater than 650 nm, suppressed the development of urticaria induced by 400 nm monochromatic radiation. On the basis of these findings and our previous observation of an inhibitory spectrum in two cases of solar urticaria, we suggest that there is also an inhibitory spectrum in PCT. This could explain the extremely low incidence of immediate erythematous or urticarial reactions in sun-exposed skin in these patients.
Br J Dermatol 1985 Dec
PMID:A case of porphyria cutanea tarda with experimental light urticaria. 409 85

Most patients with urticaria can be assessed by taking a relatively simple history with few or no investigations and controlled by a suitable antihistamine given at appropriate times until spontaneous resolution occurs without a complete diagnosis ever being made. Those that do not respond in this way require sometimes quite elaborate investigations, the institution of which would be an imposition in a mild case. Even after full investigation and ringing the changes of all available drugs, too many cases persist to the frustration of all concerned.
Br Med J 1973 Dec 22
PMID:Diseases of the skin. Drug therapy of urticaria. 414 15


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