Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Six of nine adults who developed Red Sea coral contact dermatitis had seafood allergies. Contact with the "fire" coral was followed by a series of skin eruptions starting with an immediate pruritic urticaria-like lesion which forced the victims out of the water. Within minutes the affected area became erythematous and edematous with eventual blister formation approximately 6 hours after the initial contact. The blisters resolved, leaving violaceous papules and plaques in a streaky fashion corresponding to where the coral brushed the skin. The lesions became shiny and lichenoid in 3 weeks while pruritus persisted. Treatment with topical corticosteroids and oral antihistamines reduced the severity of the disease but did not stop its evolution to the lichenoid stage. Complete resolution usually occurred after 15 weeks, leaving residual hyperpigmented macules.
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PMID:Red sea coral contact dermatitis. 167 31

We present 9 patients with contact urticaria due to rubber gloves. Others have reported an increasing incidence of the disease among females, patients with atopic dermatitis, and hospital personnel. Our data confirm these results. Scarification with water, in which the suspected glove was incubated, is a simple diagnostic method, both reliable and cheap, in order to test the solubility of the allergen(s) in water. In one of our patients, we proved a type-I allergy caused by tetramethyl thiuram disulfide.
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PMID:[Contact urticaria caused by rubber gloves]. 214 Feb 23

Six patients are described with a history of cold-related urticaria in whom standard tests (water-immersion and ice-cube) did not induce symptoms. Only total-body cold exposure induced generalized urticaria. Systemic cold urticaria should, therefore, be included in the differential diagnosis of cold-dependent allergic disorders.
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PMID:Systemic cold-induced urticaria--clinical and laboratory characterization. 199 20

A case is reported of ganglioneuroblastoma in a 5-year-old boy, who had urticaria syndrome by physical agents (water, light, cold) in the last 2 years, associated with an apparent splenomegaly. A sonography and a CT scan showed a large cystic mass with calcification near the left kidney. After surgery, it was possible to diagnose left adrenal ganglioneuroblastoma (Evans's first stage). Complete regression of urticaria syndrome was obtained after mass removal.
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PMID:Ganglioneuroblastoma and urticaria by physical agents. 236 74

A patient is described with cholinergic urticaria (CU) in whom the symptoms could be provoked by gustatory stimuli. The aim of this study was to investigate whether there is a threshold of sweating (monitored by skin water vapour loss (SVL) measurements) at which CU can be provoked. Provocations with lemon and sal-ammoniac liquorice induced transient sweating differing both in degree and duration. Only 'doubly salted' liquorice, which caused the most intense sweat response, resulted in urticarial lesions. This findings suggest a threshold dependency for the induction of CU. SVL measurement may be a useful method for the evaluation of sweating tests in CU patients.
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PMID:Water vapour loss threshold and induction of cholinergic urticaria. 239

We investigated the possibility that the inflammatory reaction in primary acquired cold urticaria might be associated with the release of platelet-activating factor. Six patients with the disease and five normal controls were subjected to cold-water challenges during which blood samples were obtained for measurement of the release of possible mediators: i.e., histamine, neutrophilic chemotactic activity, and platelet-activating factor-like lipid (PAF-LL). Four of the patients had pronounced experimentally induced cold urticaria with angioedema and release of mediators. Levels of the three mediators were not elevated in five normal controls or in two patients in whom cold challenges induced only mild urticaria and angioedema. The effective suppression of cold-induced urticaria in three patients treated with doxepin correlated with inhibition of PAF-LL release but not inhibition of histamine or neutrophilic chemotactic activity release. These data suggest a positive correlation between PAF-LL release and cold urticaria, although the exact relation between PAF-LL and cutaneous lesions of primary acquired cold urticaria has not yet been established.
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PMID:Association of platelet-activating factor with primary acquired cold urticaria. 241 Jul 90

Two female patients with aquagenic urticaria were studied in order to better clarify the pathogenesis of urticarial reactions to water. One patient suffered also from atopy and from cholinergic and chronic urticaria, and two of her sisters had noted aquagenic urticaria since puberty. The second patient had had aquagenic urticaria for only 2 years. Local applications of ethyl alcohol (96%) to the patients' skin did not elicit any lesions, and pretreatment of the skin with topically applied atropine did not inhibit whealing in response to water. Intracutaneous injections of aqueous extracts of human callus resulted in reproducible burning sensations in the patients' skin but not in control skin. Injections of buffer alone or of supernatants of stimulated epidermal cell suspension induced no abnormal reactions in patients' skin or control skin. Callus extracts also caused in vitro basophil histamine release from patients' peripheral blood basophils but not from cells of a healthy volunteer. These data suggest that patients with aquagenic urticaria react to a water-soluble antigen in the epidermal horny layer that diffuses into the dermis to cause histamine release from sensitized dermal mast cells.
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PMID:Evidence that water acts as a carrier for an epidermal antigen in aquagenic urticaria. 242 97

Six patients with acquired primary cold urticaria and six normal control subjects were challenged with a 5-minute immersion of an arm in cold water, at 10 degrees C, to induce cold urticaria. Venous blood draining the arm was sampled before and at 5 and 20 minutes after challenge. Prostaglandin D2 levels in the serum increased significantly after cold challenge but did not correlate with the severity of the urticaria. Significant elevations in histamine after cold challenge tended to be higher in the patients with a low threshold to cold reaction. Two markers of platelet activation, platelet factor 4 and beta-thromboglobulin, remained at basal levels 5 minutes and 20 minutes after challenge.
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PMID:Prostaglandin D2 and histamine release in cold urticaria unaccompanied by evidence of platelet activation. 245 77

A 9-year-old child with cold-induced cholinergic urticaria was studied. When exposed to cold water or ambient cold air, the patient developed generalized urticaria. The lesions consisted of punctate wheals and surrounding erythema similar to that seen in cholinergic urticaria. The patient did not react to cutaneous challenge with an ice cube and a cold water immersion test was negative. Urticaria was not provoked by vigorous exercise sufficient to cause profuse sweating. The methacholine skin test was reactive. The patient was well controlled by combination therapy with hydroxyzine plus cyproheptadine.
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PMID:Cold-induced cholinergic urticaria--case report. 266 34

Clinical details and present day problems encountered in 425 cases of falciparum malaria (PF) are reported. 10.11% had taken chloroquine prior to reporting to us. Parasitic count done in 23.05% cases lacked correlation with severity of disease. Pattern of fever varied markedly but 5.4% were afebrile throughout and presented only with bodyache and malaise. Apyrexial spell was noted in 5.64%. 28.70% had typical facial looks of anaemia and sallow complexion. Cerebral symptoms were noted in 3.05%. Other symptoms were severe headache 33.4%, pain abdomen 3.29%, gastroenteritis 5.64%, jaundice 2.58% and bronchitis in 7.50%. We encountered subconjunctival haemorrhages with purpura and/or urticaria in four cases, symptoms suggestive of shock lung in 3, pulmonary oedema in 2, severe anaemia (HB less than 4 g%) in seven pregnant ladies, extrapyramidal symptoms in follow up period in 5 and congenital malaria in 2 cases. 83.25% were cured with chloroquine and oxytetracycline. 8.47% (who deteriorated despite the above treatment) were treated with quinine for 6 days. 5.17% (with severe disease) were also given quinine as first line drug. 2.82% (unresponsive to chloroquine and oxytetracycline but with mild disease) were treated with pyrimethamine-sulphamezathine combination for 5 days. One case who did not respond to quinine was treated with quinidine. Recrudescence was seen in 3.67% of patients treated with chloroquine and oxytetracycline. There was no case with renal failure, haemolysis due to G6PD deficiency and black water fever. There was only one death (0.23%) in our series. Self-medication, haphazard therapy and the slogan "Fever may be malaria-take chloroquine" can lead to problems in falciparum malaria.
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PMID:Falciparum malaria--present day problems. An experience with 425 cases. 269 36


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