Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

With advances in technology, several in vitro screening tests such as MAST and CAP system have been used for analyzing the allergens involved in allergic diseases such as bronchial asthma (BA), allergic rhinitis (AR), atopic dermatitis (AD) and urticaria. In this study, CAP system (Pharmacia, Sweden) was used to screen the prevalence of allergens responsible for these atopic diseases. A total of 392 children were enrolled in this study retrospectively, all these atopic children visited the allergy clinic of the Department of Pediatrics, National Taiwan University Hospital during the period March 1995 and August 1995. Our results showed: (1) Among these 392 allergic children, included 82 BA, 70 AR, 22 AD, 156 BA + AR. 8 BA + AD, 12 AR + AD, and 42 AD + AR + AD: (2) House dust mites (Dermatophagoides pteronyssinus: D. p and Dermatophagoides farinae: D. f) are the most common allergens triggering atopic disease in the Taiwan area. (3) Total IgE level is the highest in three combined allergic disease (BA + AR + AD) [2179.9 +/- 504.2KU/L] and lowest in single disease (AR) [503.1 +/- 84.8 KU/L]. Mite-specific IgE (D. p + D. f-specific IgE) concentration is also the highest in three combined disease (BA + AR + AD) [499.1 +/- 86.0KU/L] and lowest in AR [159.5 +/- 47.5 KU/L], (4) elevated specific IgE antibody to egg white and milk were found in 68.4% and 47.4% of patients with AD and/or urticaria. In conclusion, these data suggest that house dust mites, are the most important allergens in respiratory allergy as well as in atopic dermatitis, while food allergens play relatively important roles only in skin allergy. Furthermore, the highest IgE level was noted in children with combined allergic diseases.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi
PMID:Analysis of total IgE and allergen-specific IgE antibody levels of allergic children in Taiwan. 940 Nov 82

In the past 2 years, a 4 year-old boy has had an anaphylactic reaction whenever he contacted food prepared with fish. The symptoms included intense itching in the throat and eyes, which progressed to generalized urticaria and facial angioedema. This was accompanied by cough, wheezing and dyspnea. Many fish preparations caused these episodes including several different kinds of fish (cod, tuna, salmon, trout, eel...), fish soup, chopsticks contaminated with fish preparations and canned fish. Elevated levels of total serum IgE (224 IU/ml) and specific IgE for cod (93.1 IU/ml), tuna (> 100 IU/ml), salmon (> 100 IU/ml), trout (64.4 IU/ml), mackerel (41.2 IU/ml) and eel (28.1 IU/ml) were found by the Pharmacia CAP system RAST FEIA in our allergy clinic. A skin prick test for mixed fish extracts (contain flounder, cod and halibut) was positive. A fish challenge test for cod, tuna, salmon, trout and eel all showed anaphylactic reactions. His allergic symptoms stabilized gradually after strictly avoiding ingestion of fish and using drug treatment. He also had a similar anaphylactic reaction to frogs. The best treatment for fish allergy is avoidance. Avoidance of fish may need to include both ingestion and inhalation of cooking vapors.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi
PMID:Fish induced anaphylactic reaction: report of one case. 968 28

The occurrence of allergic diseases in preschool children was studied on the basis of a questionnaire sent to the parents of 5,408 kindergarten students, 3 to 6 years of age, in Taichung City. The overall response rate was 81% and included 2311 (52.8%) boys and 2062 (47.2%) girls. Allergic diseases had been recognized in 34.6% of the children. The cumulative (lifetime) prevalence of bronchial asthma (BA), allergic rhinitis (AR), atopic eczema (AE), and urticaria were 9.4%, 26.4%, 6.6% and 6.8%, respectively. The current (past 12 months) prevalence of BA, AR, and AE was 6.7%, 14.8%, and 3.5%, respectively. BA and AR occurred more frequently in boys than in girls (P < 0.001); no significant difference was found between boys and girls in AE (P = 0.328). There were statistically significant relationships between positive family history and BA, AR and AE (P < 0.001). In conclusion, allergic diseases constitutes an important health problem for pre-school students in Taichung City.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi
PMID:Allergic diseases in preschool children in Taichung City. 982 76