Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The C1-inactivator plays an important role not only in the initial phases of the complement system, but also in those of the coagulation, fibrinolysis and kinin systems. The present study was concerned with the reciprocal influence of decreased C1-inactivator levels in patients with hereditary angioneurotic edema (HANE, HAE). In 13 HANE-I patients there were significantly increased levels of the coagulation factors XII, XI, V, of plasminogen and of alpha 2-antiplasmin, while the factors IX and VII were decreased. Conversely, it emerged that in patients with markedly raised prephase factor levels, angioneurotic edema occurred in the presence of normal or only slightly decreased C1-inactivator levels. However, the ratio between factor XI and C1-INA activity was significantly higher than in normal and urticaria patients. Factor XII, HMWK, XI, VIII and V levels were significantly raised in 10 patients with frank chronic urticaria, while factor VII was lowered. Numerous other factors and inhibitors of the coagulation, fibrinolysis and kinin systems were, however, normal or showed no significant differences.
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PMID:Interaction between C1-INA, coagulation, fibrinolysis and kinin system in hereditary angioneurotic edema (HANE) and urticaria. 651 10

Twenty one patients having drug eruptions are reported. The causative drugs were confirmed by provocation Tests. Eleven patients had exanthematous eruptions. The causative drugs were thiacetazone (3), para aminosalicylic acid (3), i-sonicotine acid hydrazide (1), Stereptomycin (1), ethambutol (1 , carbamazepine (1 and phenytoin sodium (1). In 4 patients having toxic epidermal necrolysis, the causative drugs were para aminosalicylic acid (2) isonicotinic acid hydrazide (1), streptomycin (1), tetracycline (1) and phenobarbitone (1). Two of these patients reacted to two drugs each, namely, streptomycin and para aminosalicysclic acid; and tetracycline and phenobarbitone respectively. In 3 patients with ex o ative dermatitis , the causative drugs were isonicotinic acid hydrazide (1), streptomycin (1), thiacetazone (1), and chloroquine (1).One patient reacted to both thiacetazone and chloroquine. In 3 patients who presented as urticaria, the causative drugs were analgin (1), phenylbutazone (1), and dilantin sodium (1).
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PMID:Drugs Causing Skin Eruptions. 2819 71