Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

2380 sessions of ultraviolet blood irradiation have been analysed. A DRB-8 lamp was used as a source of irradiation. The complications observed were divided into 2 groups. Group 1 comprised complications associated with the technical performance of the manipulation, their rate being 1.3%. Group II comprised complications developed in ultraviolet blood irradiation. The complications observed in group II were as follows: rigor in 4 cases, hypotension in 2 cases, nasal bleeding in 3 cases, hypoglycemia in 1 patient, bronchospasm in 1 patient and urticaria in 1 patient. To prevent the onset of complications medical care and the oral intake of carbohydrates are recommended for 1.5-2 h after the session. Intramuscular injections are to be avoided for 1.5 h for fear of the appearance of hematomas.
 ...
PMID:[Complications in ultraviolet irradiation of the blood]. 207 72

The major histocompatibility complex (MHC) acts as a marker for self during T-cell ontogeny and is associated with the pathogenesis of many autoimmune diseases. Recent investigations have shown about 30% of patients with chronic idiopathic urticaria (CIU) have IgG autoantibodies against the high-affinity IgE receptor, FcepsilonRI, or IgE. A link between MHC class II alleles and CIU has not been reported previously. DNA was extracted from blood of 100 Caucasian patients with CIU, and the MHC class II type determined using the polymerase chain reaction with sequence-specific primers, testing for DRB and DQB1 alleles. The frequency of alleles in CIU patients was compared with that found in 603 controls. Further human leucocyte antigen (HLA) typing on patient subsets, classified by the patients' responses to intradermal injection of autologous serum and their serum-induced histamine release from basophil leucocytes of healthy donors, was undertaken. HLA DRB1*04 (DR4) and its associated allele, DQB1*0302 (DQ8), are raised in CIU patients compared with a control population (P = 2 x 10-5 and P = 2 x 10-4, respectively). HLA DRB1*15 (DR15) and its associated allele, DQB1*06 (DQ6), are significantly less frequently associated with CIU. The HLA DRB1*04 association is particularly strong (corrected P = 3.6 x 10-6) for patients whose serum has in vivo and in vitro histamine-releasing activity. HLA class II typing is consistent with the concept that CIU is a heterogeneous disease, and supports an autoimmune pathogenesis in a subset of patients.
 ...
PMID:Human leucocyte antigen class II associations in chronic idiopathic urticaria. 1035 22