Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this study, four patients presented with chronic urticaria that required glucocorticosteroid therapy for control. In the first patient, the urticaria began during pregnancy and persisted after delivery with symptoms flaring premenstrually thereafter. Danazol was selected in an attempt to suppress progesterone levels, theoretically by inhibiting ovulation. The patient's urticaria markedly improved, however, within 24 hours. Several months later, she was switched to stanozolol with further improvement. Three other individuals were treated with stanozolol with dramatic improvement. In all, three patients have experienced the induction of five remissions (there were two recurrences), and one patient remains much improved. All subjects have stopped both stanozolol and glucocorticosteroids. Stanozolol appears to act synergistically with glucocorticosteroids, and together, they may be capable of inducing remission in some patients.
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PMID:The treatment of glucocorticosteroid-dependent chronic urticaria with stanozolol. 340 67

Anabolic steroids are synthetic derivatives of testosterone that were developed in the 1950s in an attempt to dissociate the anabolic and androgenic effects of testosterone. The anabolic steroid stanozolol has been particularly helpful because it has one of the largest anabolic/androgenic ratios. In addition, stanozolol has substantial fibrinolytic properties. We discuss the safety profile and the use of stanozolol for a variety of clinical applications. Stanozolol is approved for use in the treatment of hereditary angioedema, but numerous reports have detailed the effectiveness of this agent in the treatment of urticaria, Raynaud's phenomenon, and, more recently, cryofibrinogenemia and lipodermatosclerosis. Side effects are mostly dose related and are preventable with appropriate follow-up.
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PMID:Stanozolol as a novel therapeutic agent in dermatology. 762 53

Early recognition and treatment of life-threatening dermatoses can reduce morbidity and mortality. Pemphigus vulgaris can usually be brought under control with high doses of corticosteroids. In cases of necrotizing fasciitis, early, extensive debridement of involved tissue is essential, since antibiotic therapy alone has little effect. Patients with toxic epidermal necrolysis and occasionally those with Stevens-Johnson syndrome may need care similar to that required for a major burn. Therapy for toxic shock syndrome includes aggressive fluid replacement and beta lactamase-resistant antistaphylococcal antibiotics. Treatment of urticaria and acquired angioedema includes histamine receptor blockers, prednisone (for intractable cases), and epinephrine (for respiratory compromise); danazol (Danocrine) or stanozolol (Winstrol) may be useful for prophylaxis of hereditary angioedema.
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PMID:Dermatologic emergencies. When early recognition can be lifesaving. 793 18