Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report a case which illustrates occupational sensitivity to Papain with life-threatening anaphylaxis. In addition to urticaria and angioedema and glottic symptoms, the patient demonstrated annoying intermittent problems mimicking rheumatoid, gastrointestinal, cardiac, and pulmonary disease. All symptoms and signs disappeared after he removed himself from direct occupational exposure to Papain, and he was able to continue working in a setting five stories removed from the powder. The ubiquitous presence of Papain in our daily lives, in the bathroom, dining room, hospital, or workplace establishes it as a significant contaminant. This case emphasizes the value of including papaya as a scratch testing antigen in clinical practice.
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PMID:Papain anaphylaxis: a case report. 323 62

Papain is a plant protein with a wide pharmacological, domestic and industrial use. It leads a high sensitisation, being the most common rotue of entry the inhalation. The occupational allergy to papain in exposed workers was described some years ago, being presented with bronchial asthma, rhinitis or both. In most of the cases, the specific IgE was positive. We present a case contact urticaria, rhinoconjunctivitis and bronchial asthma per papain of occupational origin. Papain prick test, specific IgE and nasal challenge were positive. The peak flow record showed diary decreases during the working week and the basal spirometry showed obstruction to the airflow. The patient was moved away the place where papain was handled and this resolved the clinical symptoms and the spirometry returns to the normal values. We present a case of IgE-mediated allergy, vehicled by tow routes: contact and airborne. The latest produced clinical manifestations later. Papain was used as Cephalopoda softening, because of that it worth emphasising its seasonal use.
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PMID:[Contact urticaria, rhinoconjunctivitis and bronchial asthma from occupational use of papain]. 1056 79