Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The overall hypersensitivity reaction rate among 14,249 U.S. Marine Corps personnel who received 36,850 doses of an investigational Japanese encephalitis vaccine was 10.3 per 10,000 doses; reaction rates were 16.1 and 10.3 per 10,000 doses for the first two doses, and 2.0 per 10,000 doses for the third. The reaction rate was 26.7 per 10,000 vaccinees. Of 38 reactors, 26 had urticaria and/or angioedema, and 11 had pruritus. Vaccine reaction intervals clustered within 48 hours for dose 1, but the median reaction interval for dose 2 was 96 hours. A history of urticaria or allergic rhinitis was associated with an increased probability of a vaccine reaction.
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PMID:Systemic reactions in U.S. Marine Corps personnel who received Japanese encephalitis vaccine. 911 60

We have found two different patterns of systemic immediate-type reactions to Japanese encephalitis vaccine containing gelatin as the stabilizer. One group of affected children had cutaneous and respiratory symptoms (e.g., systemic urticaria and wheezing) and the other group had cardiovascular symptoms (e.g., hypotension and cyanosis) without cutaneous and respiratory symptoms. The children in the former group had anti-gelatin IgE in their sera, whereas those in the latter group did not. We think that the two patterns may be caused by different mechanisms or different allergens.
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PMID:Two patterns of systemic immediate-type reactions to Japanese encephalitis vaccines. 960 11