Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The article presents a case of 56-year-old patient, female, who developed generalized urticaria following dental treatment. The wheals appeared four hours after she left the clinic. During stomatological treatment she was given parapaste, a complex drug, consisting of cinchocaine, eugenol, paraformaldehyde and glycerin. She was admitted to hospital and was treated with prednison and cetirizine. The symptoms resolved in one day and she was discharged. This was the second episode of urticarial reaction to after dental visit. In a previous case, several months earlier, she received parapaste and Scandonest, local anaesthetic. She visited an allergologist after three weeks and skin prick tests with common allergens were done. All were negative. Then the prick tests with the ingredients of parapaste were done resulting in 5 mm diameter wheal to the solution of formaldehyde. We performed RAST to formaldehyde - the result was confirming the presence of antibodies to formaldehyde in a third class. The diagnosis of sensitization to formaldehyde was made. The incidence of allergy to dental drugs was discussed.
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PMID:[Allergy to formaldehyde]. 1562 56

Hyaluronidase is a goat testicular protein that hydrolyzes hyaluronic acid, a structural component of the intercellular matrix. It is commonly used as a spreading factor to improve the diffusion of drugs, including local anesthetics and chemotherapeutics. We experienced a 55-yr-old female with generalized urticaria that developed within 1 hr after the epidural injection of hyaluronidase. She had a history of allergic rhinitis, and had suffered from post-herpetic neuralgia and a herniated disc for several years. To relieve her pain, she had been given epidural injections consisting of mepivacaine hydrochloride, triamcinolone acetonide, and morphine sulfate biweekly for one year. Hyaluronidase had been administered several times with these drugs before this episode of generalized urticaria. Skin prick testing showed a positive response to 1,500 IU/mL of hyaluronidase extract, as compared to histamine. The patient's serum hyaluronidase-specific IgE level, determined using an enzyme-linked immunosorbent assay (ELISA), was markedly elevated, as compared to unexposed healthy controls. An IgE immunoblot analysis using hyaluronidase extract and the patient's serum showed IgE binding components at 31 and 21 kDa, whereas no corresponding IgE binding component was found in healthy controls. An ELISA inhibition test showed significant, dose-dependent inhibition with the serial addition of hyaluronidase extract. This is the first case of an IgE-medicated allergic reaction to goat (Naemorhedus goral raddenus) hyaluronidase, demonstrated by skin testing and a specific IgE and immunoblot assay.
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PMID:Acute urticaria caused by the injection of goat-derived hyaluronidase. 2022 71