Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Based on experiences in homes for the aged in Singapore, the following may be useful guidelines when dealing with dermatological cases in old people: Diagnosis can be difficult: common diseases come first. The clinical picture is often altered by the patient's self-medication: search for the primary disease. Expect considerable interference of your therapy by other medication. Keep therapy as simple as possible. Refrain from oral medication. Scabies is more common than usually thought and often difficult to recognize when the general standard of hygiene is high. Creams and ointments are not helpful in stasis eczema and leg ulcers. Diuretics often do not work in ankle oedema and its skin complications. Compressive bandages or elastic stockings are cheaper and safer. Antihistaminics rarely work to relieve itch, but cause considerable drowsiness. Use them only for urticaria. Many elderly have a dry skin: soap can cause itch and dermatitis.
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PMID:Skin problems in the aged. 359 1

Omeprazole is a substituted benzimidazole that has gained widespread use in the treatment of acidic and peptic ulcer disease. Adverse events with the drug are rare and involve mainly the gastrointestinal and central nervous systems. Skin inflammation, urticaria, pruritus, alopecia, and dry skin have been reported in 0.5-1.5% of patients. To date, no published report has linked angioedema with omeprazole. We report a case of a 34-year-old woman with cellulitis, ulcerative erosive esophagitis, and gastric and duodenal ulcers who developed several hypersensitivity reactions characterized by shortness of breath, wheezing, cough, mild angioedema, and total body urticaria and pruritus. These symptoms correlated with the addition of omeprazole to her regimen and the timing of its administration. A previous case report prompted a rechallenge with enteric-coated omeprazole granules removed from the capsule shell. Recurrence of the adverse events suggested an allergy to the drug itself and not the capsule. Angioedema can be a life-threatening allergic reaction requiring immediate treatment. Rechallenge using omeprazole with or without the capsule shell should be done only in a hospital setting where prompt action can be taken in the event of an emergency.
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PMID:Angioedema and urticaria associated with omeprazole confirmed by drug rechallenge. 815 96

To estimate the prevalence of hand eczema, a questionnaire was distributed to 901 male car mechanics. Of the 801 persons who responded, 15% reported hand eczema on some occasion in the previous 12 months, and 57% admitted dry skin on the hands. In a 2nd part of the study, those who reported hand eczema were examined and patch tested with a standard series and a special "car mechanics' series". The most common diagnosis was irritant contact dermatitis, 55%, and 2nd was allergic contact dermatitis, 19%. 35/105 (33%) had a total of 51 positive patch test reactions, all to substances in the standard series, except for 2 persons who reacted to oxidized d-limonene. The most frequent reactions were to thimerosal (9%), nickel (8%) and colophony (5%). One plausible explanation for the high prevalence of nickel allergy was the common use of nickel-plated tools. 5 individuals had a history of contact urticaria, but scratch tests were negative. It was concluded that car mechanics are at high risk for contact dermatitis on the hands, irritant as well as allergic.
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PMID:Hand eczema in car mechanics. 818 10

Moisturizers are widely used in various dermatologic and cosmetic skin therapies. Different classes of moisturizers are based on their mechanism of action, including occlusives, humectants, emollients and protein rejuvenators. Commercially available moisturizers often utilize components of each of these classes to provide their beneficial effect. Dry skin (xerosis) is the major indication of use. Others include atopic dermatitis, irritant contact dermatitis, ichthyosis, and dermatoheliosis. Although generally efficacious, moisturizers can cause a number of unwanted side-effects, including occlusive folliculitis, irritation, allergic contact dermatitis and contact urticaria.
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PMID:Moisturizers: what they are and how they work. 1181 97

Atopic eczema is a chronic inflammatory condition affecting mainly children and is one of the most common skin disorders in the Western world. It has a strong genetic component associated with atopic conditions such as asthma, hayfever or urticaria. The onset is usually within the first year of life and it affects mainly the face, after which the pattern often changes to involvement of the flexures. The most prominent characteristic of atopic eczema is pruritus (itch) together with dry skin. An important treatment of atopic eczema is the application of emollients (moisturizers) to rehydrate and restore the barrier function of the skin. Wet wrapping using large quantities of emollients is a well recognized therapy for atopic eczema and other dry skin conditions. The introduction of new Tubifast Garments by Medlock Medical makes this topical therapy easy to apply for parents and carers in the management of children's eczema.
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PMID:The benefits of Tubifast Garments in the management of atopic eczema. 1590 45

Pruritus, or itch, is a common sensation that causes a person to want to scratch. It is a complex process that may negatively impact quality of life and commonly occurs with skin disorders such as atopic dermatitis and urticaria. It could also be a symptom related to an underlying disease process such as cholestasis or hyperthyroidism, or simply be caused by dry skin, especially in the cold, winter months. Therapy is often aimed at eliminating the underlying cause first, followed by the management of the itchy sensation. Treatment may include prescription and over-the-counter (OTC) medications, herbal remedies, hydrotherapy, phototherapy, and ultraviolet therapy. This overview provides information regarding the various management and treatment options for pruritus.
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PMID:Management and treatment of pruritus. 1736 13

In this study, cutaneous toxicities associated with the administration of chemotherapy in combination are discussed. Rapidly growing cells are the targets of chemotherapy, so the skin, hair follicles, and nail matrix are frequently affected by chemotherapy. Chemotherapy skin reactions are more likely toxic than allergic reactions. There are numerous chemotherapy-induced cutaneous reactions that have been described in the literature. In addition to a variety of miscellaneous reactions, 19 major cutaneous reactions were discussed in current study. This study was designed to evaluate the clinical spectrum of all cutaneous toxicities over two years in hospitalized and ambulatory patients in the Department of Pediatric oncology and to establish probable relationship between the reaction and suspected anticancer protocol with the help of WHO (World Health Organization) Common Toxicity Criteria by Grade. The data on the cutaneous toxicities were analyzed by percentile and ranking method. The minimal (0.8%) cutaneous adverse effects monitored during the study were Petechiae, photosensitivity, pruritus, urticaria, wound-infection, erythema multiforme, hand-foot skin reaction, injection site reaction, dry skin. Alopecia was the single most common (64.3%) adverse effect observed during the study, where as the pigmentary changes were the second most common (18.2%) adverse effect monitored. While these side effects are generally not life threatening, they can be a source of significant distress to patients, especially alopecia.
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PMID:Toxic effects of multiple anticancer drugs on skin. 2006 60

The cause of pruritus can be as benign as dry skin or as serious as liver disease. A variety of other conditions may trigger itching in active people, including eczema, heat rash, Grover's disease, sunburn, cholinergic urticaria, exercise-induced anaphylaxis, contact and systemic allergic reactions, infections, parasites, and several systemic diseases. Most of these conditions can be effectively managed with treatments that range from avoidance of environmental irritants to the use of topical agents, antihistamines, systemic corticosteroids, or antibiotics.
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PMID:Itching in active patients: causes and cures. 2008 59

A 3-day-old, 57.3-kg, male white rhinoceros (Ceratotherium simum simum) neonate presented laterally recumbent with comatose mentation, cold extremities, and severe hypothermia, hypoxemia, and hypoglycemia. Critical care support was initiated with aggressive fluid and warming support as well as dextrose and oxygen supplementation. After initial stabilization, additional complications arose in subsequent weeks including intermittent diarrhea, dry skin with loss of epidermal layers, urticaria on the head, and superficial wounds on the face, ears, feet, and penis. There is a lack of critical care information for rhinoceros calves. However, due to similarities to other Perissodactylids, some general guidelines for critical equid neonatal care were implemented. The calf was hand-raised until weaning and is now a subadult white rhinoceros with no abnormalities.
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PMID:Critical care for a hypothermic and hypoglycemic white rhinoceros (Ceratotherium simum simum) calf. 2531 36

Imatinib mesylate (imatinib) is a tyrosine kinase inhibitor initially approved by the US Food and Drug Administration in 2001 for chronic myeloid leukemia (CML). Since then, the number of indicated uses for imatinib has substantially increased. It is increasingly important that dermatologists recognize adverse cutaneous manifestations of imatinib and are aware of their management and outcomes to avoid unnecessarily discontinuing a potentially lifesaving medication. Adverse cutaneous manifestations in response to imat-inib are not infrequent and can include dry skin, alopecia, facial edema, and photosensitivity rash. Other less common manifestations include exfoliative dermatitis, nail disorders, psoriasis, folliculitis, hypotrichosis, urticaria, petechiae, Stevens-Johnson syndrome, erythema multiforme, Sweet syndrome, and leukocytoclastic vasculitis. We report a case of imatinib-induced lichenoid drug eruption (LDE), a rare cutaneous manifestation, along with a review of the literature.
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PMID:Imatinib mesylate-induced lichenoid drug eruption. 2839 13


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