Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Dientamoeba fragilis is a pathogenic protozoan parasite with a world-wide distribution. Although originally described as an amoeboid organism, it has been reclassified as a flagellate, on the basis of a number of electron microscopic and immunological findings. Except for its lack of a flagellum, D. fragilis closely resembles Histomonas and Trichomonas. Interestingly, a resistant cyst stage has not been demonstrated and it is unlikely that its trophozoites can survive successfully outside the human host. As a consequence of its higher than anticipated coincidence of infection with Enterobius vermicularis, transmission may occur via ova of this pinworm. D. fragilis infection may be acute or chronic, and has been reported in both children and adults. The most common clinical symptoms include abdominal pain, persistent diarrhoea, loss of appetite, weight loss and flatulence. Occasionally, eosinophilia, urticaria and pruritus have been described. Demonstration of the characteristic nuclear structure of D. fragilis, needed for a definitive diagnosis, cannot be achieved in unstained faecal material; therefore, permanently stained smears are essential. Treatment is recommended in symptomatic cases, and iodoquinol, tetracycline and metronidazole have been used successfully.
 ...
PMID:Dientamoeba fragilis: the unflagellated human flagellate. 1079 75

Blastocystis is a human common enteric protist that may colonize a large variety of non-human hosts linked to symptoms and diseases such as abdominal pain, constipation, diarrhea, urticaria, flatulence and irritable bowel syndrome (IBS). Blastocystis exhibits remarkable genetic diversity and multiple subtypes (STs) within the genus with no absolute associations with clinical symptomatology. Here we analyzed fecal samples from Argentinean patients (n=270) belonging to symptomatic (urticaria and non-specific gastrointestinal symptoms, n=39) and asymptomatic control (n=28). Those patients infected with Blastocystis (n=67) were submitted for morphological analysis, DNA extraction, 18S PCR, sequencing and STs identification according to DNA barcoding. Blastocystis vacuolar forms were the predominant morphotype (75%), ameboid-like forms were evidenced in 1.5% of samples. Blastocystis ST3 was detected in 71.6% (n=48), of which 71.4%, (n=35) and 28.6% (n=14) belonged to symptomatic and asymptomatic respectively. Other subtypes identified were ST1 (14.9%), ST6 (7.5%) and ST2 (5.9%). Blastocystis 18S barcoding evidenced in non-urticaria symptomatic patients and asymptomatic control group the presence of allele 134 (ST3) (p<0.0001), while allele 34 (ST3) was detected in 85.7% (18/21) of symptomatic uricaria as compared with control group (1/21) (p<0.0001). The presence of a particular allele (a34) significantly associated with urticaria patients was detected and the clinical implications of these findings are herein discussed.
...
PMID:Blastocystis and urticaria: Examination of subtypes and morphotypes in an unusual clinical manifestation. 2597 14

Organic farming has been promoted in Thailand by King Rama the ninth. In addition to being healthier for consumers, organic farming is healthier for agricultural workers. The cross-sectional study was conducted to investigate the frequency of chronic disease conditions, accidents, health symptoms, and ergonomic problems among 243 conventional (pesticide using) farmers and 235 organic farmers. Data were collected using questionnaires in face-to-face interviews. The results indicated symptoms that could be related to pesticide exposure (skin rashes, water blisters, headache, dizziness, and loss of appetite) were significantly higher among conventional farmers than organic farmers. The organic farmers reported significantly more health symptoms such as hives, chest pain, mild fever, flatulence, and frequent urination than the conventional farmers. The organic farmers reported significantly more pain, numbness, or weakness in the wrists/hands, fingers, upper back, hips, and ankles/feet than conventional farmers.
 ...
PMID:Difference in Accidents, Health Symptoms, and Ergonomic Problems between Conventional Farmers Using Pesticides and Organic Farmers. 3102 8