Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mast cells are the primary effector cell type in urticaria and angioedema. Recognition of different types of mast cells has increased the understanding of their cell biology and may help refine the therapy of human allergic diseases. Mast cells containing chymase and tryptase (MCTC) and tryptase alone (MCT) are two distinct types distinguished on the basis of the neutral protease composition of their granules. MCT cells are distributed primarily in the lung and gastrointestinal mucosa, whereas MCTC cells lie primarily in skin and gastrointestinal submucosa. The appearance of MCT cells in intestinal tissue is T-lymphocyte dependent, whereas MCTC cells is not. The granules in unstimulated mature MCT cells typically contain complete scrolls, whereas those of MCTC cells often contain grating or lattice substructures. Major categories for the mediators of mast cells include performed mediators present in the secretory granule, newly generated lipid-derived mediators, and cytokines.
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PMID:Mast cells and their role in urticaria. 186 92

Tryptase (T), chymase (C), carboxypeptidase A, cathepsin G-like constituent of preformed mediators contained in mastocyte granules, are a group of neutral proteases with proteolytic activity. These enzymes gives differentiation of two groups of mastocytes, MCTC and MCT as a function of the richness of enzymes. Although the functions of these molecules are becoming better and better understood, their exact roles as well as that of their inhibitors, still remain to be explored in urticaria.
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PMID:[Proteolytic enzymes and their inhibitors]. 821 29