Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A second clinical trial of the compound Ro 6-0787, which is a specific monovalent penicilloyl hapten inhibitor of allergic reactions to penicillin has been conducted by investigators from 9 different European groups in 90 patients allergic to penicillin. The effect of a combined Ro 6-0787-penicillin therapy was considered as clinically successful in the large majority of cases, since treatment with penicillin could be pursued or resumed without allergic manifestation in 42 from 46 cases (91 percent). The effect of Ro 6-0787 alone on acute allergic manifestations after interruption of penicillin therapy was more difficult to evaluate but was nevertheless considered satisfactory in 17 from 26 patients (65 percent). A depression of skin hypersensitivity to PPL and/or penicillin and penicillin derivatives sometimes persisting for weeks and months was obvious in numerous allergic patients submitted to combined Ro 6-0787-penicillin treatment. A depressing effect on antipenicillin antibody titers detected by passive hemaglutination was also manifest in some patients. Failure to suppress allergic manifestations was reported in 11 cases, among which some may have been due to insufficient dosage of inhibiting hapten. The overall tolerance of Ro 6-0787 in allergic patients has been very good. Nevertheless, the major obstacle to a wider general use of Ro 6-0787 at the present time appears to be the occurrence of positive skin reactions to that compound in approximately 5 percent of patients allergic to penicillin. It is not yet ascertained whether the occasional positive skin reactions and urticaria to Ro 6-0787 may have been due to aggregation, or incomplete dissolution of the compound or whether it reflects hypersensitivity to another antigenic determinant. With the reservation that patients with positive skin test to Ro 6-0787 have for the time being to be excluded from combined treatment, this monovalent hapten certainly offers a new possibility to resume and/or pursue penicillin therapy in patients demonstrably allergic to that drug.
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PMID:Clinical trial of Ro 6-0787, a monovalent specific hapten inhibitor of penicillin allergy. 12 71

Usually, Phadiotop is presented as an in vitro multitest to pneumoallergens that are indicated in respiratory allergy. Now, in skin allergy atopic dermatitis and reaginic urticaria-Quincke's oedema, the responsibility of pneumoallergens, particularly mites, is clear. 47 Subjects were studied. Clinical history, skin test nd specific IgE gave confirmation of allergy to pneumoallergens. This was proved by the subsequent clinical development, with, in most cases, spectacular improvement after desensitization.8 section. We have compared Phadiotop with these different clinical criteria, skin tests and Cap Rast IgE. The results favour Phadiotop and confirm its value and indication in skin allergy to pneumoallergens.
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PMID:[Phadiatop in the diagnosis of skin allergy to pneumoallergens]. 138 57

A patient with ulcerative colitis developed skin allergy to sulfasalazine, manifested by rash urticaria and generalized angioedema. The patient underwent desensitization with the drug. After desensitization, the drug was reinstituted without any adverse skin reaction. However, 2 months later the patient developed a severe pneumonitis that resolved completely on discontinuation of sulfasalazine and administration of steroids. The relationship between the various adverse reactions to the drug is discussed and the entity "sulfasalazine pneumonitis" is reviewed.
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PMID:Sulfasalazine pneumonitis. 285 99

The incidence of reactions to insect bites both local (erythema, pemphigus, oedema, itching) and systemic (urticaria, angioedema, anaphylactic shock) in Borgomanero (NO) National Health Clinic 54 was assessed. The high incidence of medical treatments for this pathology encountered reflects the fact that in the summer and in a rural area a great many people are exposed to this type of emergency. The importance of careful diagnosis (anamnesis, skin allergy tests, RAST is emphasised as a means of identifying cases at allergic risk and providing the appropriate immunotherapy.
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PMID:[Reactions caused by Hymenoptera: a first aid problem]. 340 56

H2-antagonists differ from the commonly applied antihistamines (H1-antagonists) by blocking a different spectrum of histamine-mediated pharmacologic reactions. Their effects on the skin as the target organ may be stronger, weaker, or even reverse. The main representative of this group of drugs is cimetidine. Other compounds are still in experimental stages. Some controversial effects were reported in urticaria, pruritus, atopic dermatitis, mastocytosis of the skin, and also in acne and psoriasis. With polyetiologic symptoms, as are manifested in cases of urticaria and pruritus, the efficacy of the drug may depend on the underlying disease. In acne and psoriasis, the clinical type and stage of the disease may also play a major role in the outcome of such studies. Experimental and clinical findings suggest that cimetidine has some immunomodulating effect in terms of influencing the delayed type skin hypersensitivity. The intake of cimetidine should be registered in patch testing. Application of H2-antagonists may be beneficial in diseases with reduced immune resistance (generalized mycotic infections). Serious group-specific side-effects of H2-antagonists are not yet known. Several side-effects have been reported following oral intake of cimetidine; however, their frequency seems rather low.
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PMID:[H2-antagonists and possibilities for their therapeutic use in dermatology]. 613 53

Acid anhydrides are low-molecular-weight chemicals known to cause respiratory irritancy and allergy. Skin allergy has on rare occasions been reported. 2 workers contracted hives and itching on uncovered skin after 2 months exposure to methyltetrahydrophthalic anhydride (MTHPA) and methylhexahydrophthalic anhydride (MHHPA), to which they had airborne exposure. Later, the patients also developed conjunctivitis, rhinitis, sore throat, cough or asthma. In addition to MTHPA, 1 worker was also exposed to unsaturated polyester resin (UP). Both patients' immediate allergy to MTHPA and MHHPA was verified by positive prick tests to MTHPA and MHHPA, conjugated with human serum albumin (HSA), and positive radioallergosorbent tests (RASTs) to these anhydrides. On prick testing, both patients also reacted to a phthalic anhydride (PA)-HSA-conjugate and 1 of the patients to UP-HSA-conjugate. Specific immediate allergy to UP was shown by RAST. RAST inhibition with MTHPA, MHHPA and UP-resin conjugates confirmed IgE-mediated allergy and cross-reactivity between anhydrides. Our patients had developed airborne contact urticaria caused by phthalic anhydrides, in addition to respiratory allergy. Phthalic anhydride contained in the UP resin was possibly responsible for the immediate reaction of the skin.
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PMID:Immunologic contact urticaria due to airborne methylhexahydrophthalic and methyltetrahydrophthalic anhydrides. 760 Jul 75

In Finland occupational diseases are registered by diagnosis, causative agent, age, occupation, field of work, and gender. This report analyzes in detail the 1991 statistics on gender differences in occupational allergic diseases. A total of 1314 cases of occupational allergic diseases were reported, comprising 14.2% of all registered occupational diseases. The following allergic occupational diseases were encountered: allergic contact dermatitis (412 cases), bronchial asthma (352), allergic rhinitis (319), contact urticaria/protein contact dermatitis (146), and allergic alveolitis (85). The number of cases of allergic alveolitis (men, 42 cases; women, 43 cases) and bronchial asthma (176 men/176 women) was about equal in both genders. Women were overrepresented in allergic rhinitis (195 women/124 men), allergic contact dermatitis (247 women/165 men), and contact urticaria/protein contact dermatitis (109 women/37 men). According to current knowledge, there are no great gender differences in the development of asthma or allergic rhinitis. The greater number of women with occupational respiratory allergy and immediate skin allergy may indicate that women in Finland are more exposed to type I allergens than men. The greater number of cases of allergic contact dermatitis in women may reveal women's predisposition to delayed-type allergy, or women's greater occupational exposure to contact allergens.
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PMID:Frequencies of occupational allergic diseases and gender differences in Finland. 780 93

A patient with ulcerative colitis developed a sulfasalazine-induced skin allergy manifested by a urticaria rash. The patient underwent drug desensitization. The first desensitization, done according to Holdsworth's protocol, resulted in eruption with itching at a dose of 800 mg. The second desensitization, with Das's protocol, failed to reintroduce the drug because of urticarial eruptions. The third challenge, with a more gradual increase in sulfasalazine dose than that used in Holdsworth's protocol, successfully desensitized the patient. The relationship between the drug and various adverse reactions is reviewed and the desensitization to sulfasalazine is discussed.
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PMID:Desensitization for sulfasalazine-induced skin rash in a patient with ulcerative colitis. 787 75

Urticaria is a complex problem for both primary care practitioners and patients. Patients often present in considerable distress, with pruritus and uncomfortable lesions. They are frightened and frustrated about their condition and are searching for answers. Attempting to identify the cause by evaluating patient medications, contacts, and dietary history can be challenging. A multitude of laboratory tests can be performed, but they often do not provide a diagnosis. Skin allergy testing is frequently difficult at this stage. A working knowledge of the underlying pathology and causes of urticaria is essential during diagnosis. Astute evaluation can provide the clues necessary to accurately identify and treat the problem with available medications and modalities.
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PMID:Urticaria and angioedema. A simple approach to a complex problem. 916 25

Rhinitis is extremely common during pregnancy, and asthma is one of the most common potentially serious medical problems to complicate pregnancy. Cutaneous allergy (urticaria/angioedema and eczema) also may occur during pregnancy. All of these entities may worsen with pregnancy in some patients and appear to improve in others. Uncontrolled asthma may directly threaten the fetus, and morbidity from the other illnesses may indirectly affect pregnancy through an effect on eating, sleeping, or emotional well-being. Appropriate diagnosis, avoiding triggering factors when possible; appropriate use of pharmacotherapy; and, when indicated, allergen immunotherapy usually allow these chronic conditions to be controlled during pregnancy so as to optimize both the health of the mother and that of her baby.
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PMID:Asthma and allergy in pregnancy. 920 10


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