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Query: UMLS:C0042109 (urticaria)
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Acute urticaria and angio-oedema are common in primary care and in the emergency unit. Food allergy is one possible cause. We describe gastric anisakiasis, in which symptoms are often not obviously related to eating raw fish. A study was made of patients presenting at the emergency department who had allergic symptoms such as urticaria or angio-oedema and had recently eaten raw or undercooked fish. They were divided into two groups. Patients in group A (n = 13) also had abdominal symptoms and were diagnosed as having gastric anisakiasis by fibre-optic gastroscopy where third-stage larvae of Anisakis simplex were visualized and extracted. Skin prick tests and specific IgE to A. simplex were positive. Patients in group B (n = 13) had only allergic symptoms after eating raw fish. Eleven of 13 patients had positive skin prick tests and specific IgE to A. simplex. Three of 15 control subjects had positive skin prick tests and specific IgE to A. simplex. Allergic symptoms appeared from 2 to 20 h (mean 5.0) after ingestion in group A and from 20 min to 23 h (mean 4.3 h) in group B. Gastric symptoms in group A disappeared rapidly after extraction of the larvae. Allergic symptoms disappeared in most cases within the first 24 h. We suggest that the allergic symptoms in group A as well as in group B were mainly due to parasitization by A. simplex in sensitized patients. Gastric anisakiasis may be a widely underdiagnosed clinical entity.
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PMID:Gastric anisakiasis: an underestimated cause of acute urticaria and angio-oedema? 989 48

Urticaria and angioedema are common diseases in children and adults. Approximately 15-25% of the population will have urticaria or angioedema at least once in their life-time. Urticaria is characterized as the appearance of erythematous, circumscribed, elevated, pruritic, edematous swelling of the upper dermal tissue. Erythematous swelling of the deeper cutaneous and subcutaneous tissue is called angioedema. In angioedema lesions are less pruritic but pain and burning are common. Urticaria may occur in any part of the body, whereas angioedema often involves face, extremities or genitalia. In contrast to other forms of edema there are not symmetric distribution. Urticaria and angioedema are often associated. Urticaria is considered acute if symptoms are present for less than 6 weeks, but usually in childhood lesions disappear in a few days. In chronic urticaria symptoms are longer than 6 weeks; if the episodes were of shorter duration than the symptoms-free periods urticaria is considered recurrent. Acute urticaria has been reported to be the common type in childhood and chronic urticaria is more frequent in adults. Acute urticaria is usually a self-limited benign disease in young children. Nevertheless it is an uncomfortable nuisance, interfering daily activities and sleep, and produces psychosocial impact in patients and parents (an altered self-image is always an alarming situation). Urticaria is a frequent cause of emergency room visit but few patients need to be admitted. Urticaria has long been believed to be an allergic disease but clinically it has rare been proved to be so. The basic mechanism involves the release of diverse vasoactive mediators that arise from the activation of cells or enzymatic pathways. Histamine is the best known of these substances, and elicits the classic triple response consisting of vasodilatation (erythema), increased vascular permeability (edema) and an axon reflex that increases reaction. In contrast to simple symptoms and easy diagnosis of urticaria, etiologic factors are often difficult to establish. Urticaria can be classified according to the eliciting factors and the different pathomechanisms. According to several works, clinical history carried out by a trained physician can be regarded as the most valuable diagnostic tool and extensive screening test do not contribute to etiologic diagnosis of urticaria. Only a few specific tests appeared to be valuable at this respect. In different studies about children urticaria, the most common etiological factors have been identified as infection, physical urticaria, food allergy, drug adverse reaction, parasitic infestation and papular urticaria. The aim of this work-shop is to define, describe and discuss these frequent problems.
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PMID:[Round Table: Urticaria and angioedema: introduction and classification]. 1035 10

Acute urticaria is characterized by pruritic, erythematous, edematous plaques. We report the case of a 48-year-old man with acute urticaria, whose lesions appeared yellow secondary to an elevated bilirubin level.
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PMID:Yellow urticaria secondary to hyperbilirubinemia in a patient with end-stage liver disease. 1218 72

Medicaments are reported as the most common cause of urticaria. The objective of this study was to determine, by retrospective analysis of 132 pediatric patients treated at the Pulmonology and Allergology ward of the Department of Pediatrics, Banja Luka, over a 5-year period, the scope to which medicaments act as the possible cause of urticaria. Results of the study showed that the disease manifested mostly in male children (59.8), mainly of pre-school and school age rather than <1 year age group. Acute urticaria predominated, and it was recorded in 91.7% of cases. A medicament as the possible etiologic factor of acute urticaria was found in 29.8% of cases. Regarding chronic urticaria, in most cases the cause of disease remained unknown (63.6%), whereas a medicament and infection as the possible causal factors were found in 9.1% of cases. Before the occurrence of urticaria, 37 (28%) children took some medicament. Usually, these were antibiotics (45.9%), antipyretics (35.1%), or a combination of antibiotics and antipyretics (16.2%). Penicillin V, G or ampicillin were the most frequently used antibiotics (88.2%), whereas acetylsalicylic acid was the most frequently used antipyretic (53.8%). In 28% of the children suffering from acute urticaria, apart from taking some medicament, clinically manifested infection was also recorded, mostly of the respiratory system, so it could not be stated for sure whether the medicament or infection was the etiologic factor for the occurrence of disease. In only two cases it could be stated for sure that a medicament was the cause of urticaria, one acute and chronic urticaria each
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PMID:Medicaments as the possible cause of urticaria in children. 1237 9

This month's CPG column reviews "The Diagnosis and Management of Urticaria: a Practice Parameter Part I: Acute Urticaria/Angioedema and Part II: Chronic Urticaria/Angioedema." As many as 15%-24% of the U.S. population may experience at least one episode of urticaria and/or angioedema in their lifetime. Evaluation and treatment is dependent on whether the urticaria/angioedema is acute or chronic because they are fundamentally different disorders. Acute urticaria is frequently self-limited and usually caused by an allergic reaction to an identifiable agent. Chronic urticaria is usually due to an endogenous cause, one that is difficult to identify and to treat. Due to the magnitude, potential seriousness and chronicity of urticaria and angioedema, this CPG should be quite useful to nurse practitioners in a variety of settings.
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PMID:Parameters for the treatment of urticaria and angioedema. 1247 49

The present study aimed to investigate the current prevalence of urticaria with or without angioedema among Siriraj medical students, the possible causative agent(s), the association between a history of atopy, behavior of patients seeking treatment and natural course. A cross-sectional study was conducted among 428 Siriraj medical students, Mahidol University in October, 2001. The study showed the prevalence of urticaria and angioedema to be 51.6 per cent and 19.6 per cent respectively, coexisting in 13.6 per cent but urticaria alone occurred in 38 per cent and angioedema alone in 6 per cent. There was an equal sex distribution. Acute urticaria (93.2%) was more prevalent than chronic urticaria (5.4%), and the acute intermittent type was the most common. Heat, inhalants, and contactants were more often suspected causes than food or drug allergy identified in both forms. More than half the urticaria subjects treated themselves by buying over-the-counter drugs (66%) and the remainder waited for spontaneous remission (49%) with a low percentage seeking medical advice (24% from a general practitioner, 14% from a dermatologist). An atopic history was not a major underlying factor for urticaria. Most patients with acute urticaria were free of symptoms after 3 weeks. Cases with chronic urticaria who were completely healed had a mean disease duration of 14.2 weeks. However, cases with chronic urticaria who had never had a long hive free period since the onset of the disease until the time of the study had a mean disease duration of 6 years. These findings may be useful to help educate affected persons and improve public awareness in order to prevent and manage this disease.
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PMID:Urticaria and angioedema in Siriraj medical students. 1267 42

The pediatrician is faced with evaluating a panoply of skin rashes, a subset of which may be induced by food allergy. Acute urticaria is a common manifestation of an allergic skin response to food, but food is rarely a cause of chronic urticaria. Approximately one third of infants/children with moderate to severe atopic dermatitis have food allergy. Although diagnosis of acute urticaria provoked by a food may be evident from a straightforward history and confirmed by diagnostic tests to detect food-specific IgE antibody, determination of the role of food allergy in patients with atopic dermatitis is more difficult and may require additional diagnostic maneuvers, including elimination diets and oral food challenges. The immunopathologic basis of food-allergic disorders that affect the skin and a rational approach to diagnosis and treatment are discussed. Additional disorders that are caused by or mimic ones caused by food allergy are reviewed.
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PMID:Skin manifestations of food allergy. 1277 1

Acute urticaria is commonly observed in the prodromic stage of hepatitis A and B infection as well as in hepatitis C infection, although only rare cases have been published regarding the latter. Urticaria is considered one of the pre-icteric symptoms of viral hepatitis and is related to immune-complex deposits; subsequently, it may be associated with arthritis and headache (Caroli's triad). The absence of specific presentation of acute urticaria in patients with viral hepatitis is not surprising because many other viral infections can induce similar cutaneous symptoms. On the other hand, no convincing evidence exists in which hepatitis virus infection caused chronic urticaria. Data are lacking for hepatitis B, but several series and one controlled study showed the absence of a link between hepatitis C and chronic urticaria. Systematic hepatitis virus investigations in patients with chronic urticaria probably are not cost-effective. Hepatitis B or C can occasionally induce urticarial vasculitis, but this is probably related more to vasculitis than to true urticaria.
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PMID:Urticaria and hepatitis. 1646 92

Eczema is common, occurring in 15%-20% of infants and young children. For some infants it can be a severe chronic illness with a major impact on the child's general health and on the family. A minority of children will continue to have eczema as adults. The exact cause of eczema is not clear, but precipitating or aggravating factors may include food allergens (most commonly, egg) or environmental allergens/irritants, climatic conditions, stress and genetic predisposition. Management of eczema consists of education; avoidance of triggers and allergens; liberal use of emollients or topical steroids to control inflammation; use of antihistamines to reduce itch; and treatment of infection if present. Treatment with systemic agents may be required in severe cases, but must be supervised by an immunologist. Urticaria ("hives") may affect up to a quarter of people at some time in their lives. Acute urticaria is more common in children, while chronic urticaria is more common in adults. Chronic urticaria is not life-threatening, but the associated pruritus and unsightly weals can cause patients much distress and significantly affect their daily lives. Angioedema coexists with urticaria in about 50% of patients. It typically affects the lips, eyelids, palms, soles and genitalia. Management of urticaria is through education; avoidance of triggers and allergens (where relevant); use of antihistamines to reduce itch; and short-term use of corticosteroids when antihistamine therapy is ineffective. Referral is indicated for patients with resistant disease.
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PMID:5. Allergy and the skin: eczema and chronic urticaria. 1713 59

Urticaria with or without angioedema is frequently encountered in primary care medicine. Although many patients and physicians think that urticaria is evidence of an IgE-mediated allergic reaction, often the etiology of urticaria is unknown. This uncertainty frequently results in patients enduring unnecessary lifestyle changes or extensive testing. In more persistent cases, patients achieve control of their disease only with the use of more toxic medications, such as corticosteroids, and this can lead to a range of systemic complications. Acute urticaria is typically due to a hypersensitivity reaction while chronic urticaria has a more complex pathogenesis. Antihistamines remain the mainstay of symptomatic treatment for both.
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PMID:Urticaria. 1820 22


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