Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Photosensitivity to drugs and chemicals in the elderly is more prevalent due to more frequent use of medications. Phototoxic reactions to common, orally administered drugs such as diuretics, cardiac agents and antidiabetics may occur and the reactions may be remedied by discontinuing drug therapy. Photocontact dermatitis due to the ingredients in sunscreens or other agents, such as perfumes, may also arise. Diagnosis is often confirmed by photopatch testing and subsequent avoidance of these agents leads to gradual resolution. Idiopathic photodermatoses, such as sunlight-induced polymorphic light eruption or solar urticaria, may occur and persist from an early age and, in elderly subjects, they can cause mild to marked disability. The most disturbing disorder of this type is the severe, widespread eczematous chronic actinic dermatitis, which can be difficult to diagnose. Porphyrias, such as variegate porphyria or erythropoietic protoporphyria, may persist from an early age, whereas porphyria cutanea tarda generally begins in later life. Porphyrias all have specific clinical and biochemical features and, apart from variegate porphyria, usually respond well to treatment following diagnosis. Exposure of elderly skin to sunlight may also cause deterioration of many ordinary dermatoses, particularly seborrhoeic eczema, which generally respond to protection from UV exposure and to treatment of the underlying abnormality. Progress in identifying the underlying causes, the availability of increasingly sophisticated diagnostic techniques, and improvements in sunscreen preparations and therapeutic medications will probably significantly reduce abnormal photosensitivity in the elderly in the near future.
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PMID:Photosensitivity in the elderly. 218 82

Contact allergens produce three types of reactions. The commonest reaction is allergic contact dermatitis (ACD). The commonest contactants in Singapore causing ACD are, in decreasing order of importance, nickel, fragrances, neomycin, lanolin, colophony, flavine, rubber chemicals, paraphenylenediamine, clioquinol and chromates. Another type of allergic contact reaction is immunologic contact urticaria (ICU). ICU is an IgE mediated mechanisms. Contact allergens causing ICU in Singapore are proteinaceous foodstuffs and rubber latex products. Photoallergic contact dermatitis is occasionally seen in Singapore. The commonest agent is Musk Ambrette, a perfume fixature found in male colognes.
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PMID:Common environmental contact allergens in Singapore. 228 61

Studies concerning the prevalence of skin diseases and the general dermatologic services in Ethiopia are limited. A total of 7760 patients with 9725 dermatological diseases were seen by a dermatovenereologist from September 1995 to August 1996 at Kazanchis Health center in Addis Ababa. Male to female ratio was 1.01:1.00. Three thousand eighteen (31.0%) of the total 9725 cases had prior evaluation by other health personnel, including doctors (but not dermatologists). Out of these cases, 2720 (90.1%) were misdiagnosed and mismanaged. This high percentage points to the need for further short-term dermatology training for non-dermatologists. Bacterial, fungal and viral infections were dominating, comprising 19.4%, 18.5% and 6.5% of cases respectively. Infestations (i.e., pediculosis and scabies together) represented 10% of cases. Eczemas contributed 18.1% of the total cases. Photoallergic dermatitis (4.5%), Pityriasis alba (4.4%), urticaria (2.2%), prurigo (2%), benign tumors (1.8%), lichen planus (1.6%) and melasma (1.5%) were also quite common.
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PMID:Skin diseases seen in Kazanchis health center. 1195