Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Not all side-effects are undesirable side-effects of a treatment. Under certain conditions allergic side-effects during the therapy of phasic psychotics affect a turn in the course of the basic illness and bring a premature end to depression. As a result of the observation of a sudden cure of a deep vital depression in a 73 year old patient in direct chronological connection with the appearance of an allergic urticaria, studies were carried out, in the 8 years following, of a total of 18 cases of similar circumstances; during the treatment of an endogenous depression the development of intercurrent allergic skin reactions showed: in 6 cases the psychosis completely disappeared with the development of the urticaria; in 8 cases the symptoms were considerably relieved so that only the remains of vegetative disorders persisted; in 4 cases no effect could be determined. In 2 cases the same allergic reaction was consciously provoked by a reapplication of the medicaments concerned during a following depressive phase; again with favourable results since under these conditions coincidences are not very probable, the conclusion can be made, and experimentally supported, that allergic drug reactions may be employed in the course of depressions, with careful avoidance of complications.
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PMID:[Favorable, unfavorable and indifferent side effects of pharmacotherapy of psychoses]. 14 3

The intensity of fluorescence (IF) of the 3-methoxybenzantrone (3-MBA) probe in blood lymphocyte membranes was determined in bronchial asthma and urticaria patients. A marked drop in IF was revealed during acute stages in the patients with atopic and infectious-allergic bronchial asthma and aspirin intolerance asthma. In the remission stage, the normalization or approach to normal IF levels takes place in these patients. In patients with allergic urticaria there are similar changes. In patients with pseudo-allergic urticaria an opposite type of change is observed a rise in IF in the aggravation stage and partial or full approach to standard in the remission stage. We concluded that changes in the average IF do not depend so much on changes in the ratio T- and B-lymphocytes as they do on the changes in the physical state of their membranes and that this physical state differs from each other in allergic and pseudo-allergic urticaria. The 3-MBA probe may be used for the differential diagnosis of allergic and pseudo-allergic urticaria.
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PMID:Hydrophobic probe's fluorescence intensity. 3-methoxybenzanthrone (3-MBA) in bronchial asthma and urticaria patients lymphocyte membranes. 322 44

Cimetidine, an H-2-receptor-blocking antihistamine, was used in the treatment of five consecutive patients who developed acute allergic urticaria in response to insect stings. All five had persistent hives after treatment with at least epinephrine and diphenhydramine (Benadryl, an H-1 receptor blocker). All also had been given corticosteroids. Each patient responded dramatically within 15 minutes to one IV infusion of 300 mg cimetidine. All were discharged on oral cimetidine (300 mg every six hours) and reported no recurrences or exacerbations of urticaria on follow up. There were no complications. Cimetidine may be effective in patients with recalcitrant acute allergic urticaria who are already being treated with H-1-receptor-blocking antihistamines. Controlled clinical trials should be done to confirm the efficacy of cimetidine for treatment of acute allergic reactions.
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PMID:Cimetidine treatment of recalcitrant acute allergic urticaria. 377 96

A patient presented with both allergic urticaria and hereditary angioedema. The two conditions occurred independently, the urticaria being associated with allergy to food (which could be managed by control of the diet), whereas the angioedema was associated with C1 esterase inhibitor deficiency.
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PMID:Allergic urticaria and hereditary angioedema. Independent association in the same patient. 650 70

Twenty eight patients (18 men and 10 women) with delayed pressure induced urticaria were analyzed. The average age was 35.5 years, and the illness lasted 1-20 years, 4.07 years on average. The spontaneous cessation of illness came in 8 patients after approximately 5.75 years. In 23 patients there was also a classical chronic urticaria. C3, C4, alpha 1 antitrypsin, alpha 2 macroglobulin, immunoglobulin IgG, IgA, IgM and IgE were determined for 15 patients and findings were within normal limits apart from the moderate increase of IgE in 2 patients. Fifteen patients were examined for intestinal parasites and in 3 patients they were found. Also, a pathogenetic mechanism of illness was considered: the role of histamine, proteinase inhibitors, mediators of the delayed allergic urticaria.
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PMID:[Delayed-pressure urticaria--analysis of 28 patients]. 757 40

Urticaria is characterized by the appearance of hives and pruritus. Those hives are formed by oedema and vasodilatation and they disappear when they are pressed on. The acute presentation is extremely common and affects between 10 and 20% of the population at a determined moment. In its simplest form, urticaria is envisioned to represent the same sort of wheal-and-flare reaction observed when histamine is injected into the skin. It produces erythema because of capillary vasodilatation, oedema because of increased permeability in capillary and pruritus secondary at local specific receptors stimulation. Angioedema is caused by the same pathologic alterations that occur in the deep dermis and subcutaneous tissue. Thus, an area involved with angioedema has swelling as the prominent manifestation and appearance of the skin itself may be normal. Due to reduced nerve supply in dermis, angioedema is associated with oppression and not pruritus. Immunoallergological study of urticaria and/or angioedema was requested in 133 cases from 648 from the first patient's visits to the surgery. It supposes a 20.52%. The family suspicion of etiology was food in 62 cases, chemical products in 39 cases, other factors (physical, stings, balloons and other manufactured products.) in 7 cases and 25 cases without a direct relation. Out of 100 children diagnosed of allergic urticaria-angioedema 67 was by food; the foods implicated in frequency order were: eggs and nuts, fruit, milk, vegetables, fish and shellfish. In second place, chemical products were responsible of urticaria in 12 children; five of them were positive in diagnosed proof (prick, oral challenge) for penicillin and amoxicillin, both from beta-lactamic group; two of them had and adverse reaction to anesthetic agents; other two cases were after administration of vaccination and due to tetanus toxin; and three cases were due to aspirin, confirmed by oral provocation test. In 10 children the etiological agent was latex. Other etiologies were: three cutaneous reactions after stings (two by wasps and one by mosquito) three reactions due to spices (paprika, cumin, anise, mustard) and two reactions caused by manufactures products containing additives as yellow-orange.
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PMID:[Round Table: Immunological urticaria mediated by IgE]. 1035 14

There are many types of urticaria and the principal form of assessment is by clinical history and examination. Urticarial weal formation involves acute, reversible vasodilatation and increased vascular permeability. If the process is deeper the more diffuse swelling is termed angio-oedema. The major types of urticaria include allergic, physical and idiopathic forms. In allergic urticaria, IgE-mediated degranulation of mast cells results in weals of short duration which typically respond well to antihistamines. Physical urticarias are induced by physical insults including pressure, scratch, cold, etc. The distribution and duration of individual weals may suggest the causal factor. Chronic idiopathic urticaria can be very variable, with individual weals lasting between 90 min and 24 hours. Longer-lasting weals are less responsive to anti-histamines and clearly involve other mediators. When long-lasting weals fade leaving a bruised appearance urticarial vasculitis is present which may only respond to systemic corticosteroids. In a proportion of individuals with chronic idiopathic urticaria, auto-antibodies are present with specificity for the high affinity receptor for IgE or sometimes, for IgE itself. In general laboratory tests for allergic factors or other assessments of general health are completely unhelpful.
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PMID:Assessment of urticaria and angio-oedema. 1044 23

A case of allergic urticaria due to erythritol is herein reported. A 24-year-old female presented with severe wheals over her whole body. The urticaria occurred after she had drunk a glass of canned milk-tea. When the cause of her skin reaction was examined, it was found that the drink contained erythritol; this was determined to have caused her urticaria. Erythritol has recently been used as an artificial sweetener in many kinds of foods and drinks because it contains no calories. Food and drink additives should thus be included in the differential diagnosis of allergic urticaria.
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PMID:A case of allergic urticaria caused by erythritol. 1077 41

High prevalence of allergic diseases necessitates search for new methods of laboratory diagnosis thereof. We studied the diagnostic significance of the count of cells expressing low-affinity receptors to IgE (CD23+ cells) and compared this test with skin tests with non-infectious allergens and measurement of total serum IgE. 104 patients with various forms of chronic relapsing urticaria were examined. The count of CD23+ cells was markedly increased in atopic urticaria. The increase in the count of these cells and correlation with the results of skin test were less expressed in infectious allergic urticaria. In other forms of chronic urticaria characterized by negative results of skin tests the count of CD23+ cells was normal. The level of total serum IgE was low virtually in all patients. Hence, the count of cells carrying low-affinity receptors to IgE is highly informative, detecting IgE-mediated reactions in the patients, though this parameter does not allow identification of the allergen. This test can be used in complex with other methods of allergodiagnosis, particularly in cases when skin tests are for this or that reason impossible.
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PMID:[Immunological aspects of laboratory diagnosis of chronic urticaria]. 1139 27

A careful drug history should be obtained from all patients with acute or chronic urticaria/angioedema, especially in the elderly. Although strictly comparable data are lacking, drug-induced urticaria appears to be more common in developed countries than in Malaysia, at least in a Hospital setting. Culprit drugs include antibiotics, analgesics and contrast media. Pseudoallergic drug-induced urticaria mimicks true allergic urticaria, but without an evident immunological basis, and is at least as common as the allergic type. In Malaysia, and in many other countries compulsory, ingredient labelling of 'traditional' medicines would do much to reduce the frequency of drug-induced urticaria.
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PMID:Drug-induced urticaria and angioedema: pathomechanisms and frequencies in a developing country and in developed countries. 1203 95


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