Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The Katayama syndrome, the early stage of schistosomal disease, occurs 3 to 6 weeks after infection. The main symptoms are fever, urticaria, oedema and general malaise. Eosinophilia is a constant finding. The syndrome developed in a group of Dutch tourists after a visit in early November 1975 to the Omo National Park, southwest Ethiopia. Eight out of 10 infected persons became clinically ill. The incubation period varied from 4 to 41 days with a mean of 26 days. Pyrexia occurred in 6 patients, usually associated with headache and muscle pains; only to one patient the fever lasted for more than two weeks. Fever followed by oedema was present in one patient. Two patients were afebrile, one suffered from urticaria, the other from general malaise. Two visitors remained asymptomatic, but the results of serological tests showed that they were also infected. The liver function was disturbed in one patient during the febrile period and further deteriorated during treatment with niridazole. S. mansoni eggs were detected in small numbers in two patients, 6 months and 19 months after infection. Obviously the tourists harboured few adult worms. They probably had been infected by few cercariae; the possibility that they were infected by cercariae of a S. mansoni strain not well adapted to man was considered.
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PMID:The Katayama syndrome; an outbreak in Dutch tourists to the Omo National Park, Ethiopia. 724 38

Schistosomiasis is increasingly reported in travelers to subSaharan Africa.1,2 Bathing in tropical lakes3 or in other fresh waters2,4 is a recognized risk factor for acquiring it. Most cases present with cercarial dermatitis or, 3 to 6 weeks after infection by Schistosoma mansoni1,2 (occasionnally Schistosoma haematobium), with acute schistosomiasis (Katayama syndrome), when the immune response of the body to the larval maturation and migration elicits fever, sweating, arthralgia, urticaria, and digestive or respiratory symptoms. Late and unusual clinical presentations in travelers include features of spinal cord compression5,6 and ectopic dermal or genital localization,3,7 which can result from a missed diagnosis of the early symptoms of the disease. In the following case, a female traveler developed genital schistosomiasis 1 year after a missed diagnosis of Katayama syndrome.
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PMID:Genital Schistosomiasis After a Missed Diagnosis of Katayama Syndrome. 981 65

Despite treatment for malaria two travellers who acquired fever in Africa continued to have complaints: a 25-year-old Dutch woman and a 25-year-old Australian man. On questioning they appeared to have swum in Lake Malawi and a diagnosis of acute schistosomiasis was made, confirmed by serological tests. This syndrome, also called Katayama fever, is characterized by fever, oedema, urticaria and eosinophilia. The aetiology is not fully elucidated but it is supposed to be caused by immune complexes initiated by maturing worms and eggs. Patients who acquired fever in an endemic area must be questioned about contact with fresh water. Serological tests are important for the diagnosis. Treatment is with praziquantel but it is advised to treat only after the acute phase. During the acute manifestations corticosteroids may be necessary. Prevention is by avoiding contact with infected water. There is no vaccine. The role of artemisinin drugs in prevention is currently being studied.
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PMID:[Acute schistosomiasis: fever and eosinophilia, with or without urticaria, after a trip to Africa]. 1121 50

A 35-year-old man presented with fever and severe urticaria after visiting Uganda. His symptoms were caused by acute invasive schistosomiasis, also known as Katayama fever.
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PMID:[Diagnostic image (391). A man with fever and urticaria after a trip to Uganda]. 1900 10