Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The author presents the case of a male patient, 60 years old, suffering a chronic obstructive bronchopneumopathy with cor pulmonale in a state of cardiorespiratory insuffiency. Without any personal or familial history of allergy, a few minutes after the ingestion of .5mg of Digoxin a picture occurs of urticaria, angioneurotic edema and asthmatic crisis that disappears with sympatheticomimetics. No other medication was used, previously or at the time. The existence of reaginic antibodies is made evident with positive reactions to Digoxin and C Lanatosid in a Leftwich passive transference test and cutaneous tests. No alteration was found in the number of platelets and leucocytes nor in the percentage of eosinophils within 24 hours after the anaphylactic accident. The oral provocation test with the excipient of the commercial preparation was negative; the tolerance to Methyl-Digoxin complete. The literature referring to sensitization to digitalis glycosides is reviewed and some consideration is given to its mechanism.
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PMID:[Sensitization to digoxin with demostration of reagini antibodies]. 46 17

Infants with cardiopulmonary disease develop severe illness from respiratory syncytial virus (RSV) infection. Safety, feasibility, and pharmacokinetics of intravenous gamma globulin (IVIG) to prevent RSV illness were studied in 23 high-risk infants in a phase I trial. IVIG with an RSV neutralizing antibody titer of 1:1,100 in 5% solution was given monthly over a 2- to 4-h period in a clinical setting during the RSV season. The first group (n = 7) received 500 mg/kg of body weight, the second group (n = 9) received 600 mg/kg, and the third group (n =7) received 750 mg/kg. Serum was drawn prior to infusion and 2, 14, and 30 days after infusion. Total immunoglobulin G and RSV A2 and RSV B neutralizing antibody levels were obtained after the first IVIG infusion. Two children developed mild reversible pulmonary edema (group receiving 600 mg/kg per dose), and one developed hives and wheezing during one infusion (group receiving 500 mg/kg per dose). Twelve children developed subsequent RSV infection during two RSV seasons (November to April) over a 2-year follow-up period; 9 of 12 developed infection during the infusion year. Eleven illnesses were mild; one child died of progressive RSV illness (group receiving 500 mg/kg per dose). A cumulative infusion effect was not observed. IVIG appears safe and feasible in an outpatient setting, and at 750 mg/kg per dose, a target RSV antibody level of greater than or equal to 1:100 was achieved.
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PMID:Use of intravenous gamma globulin to passively immunize high-risk children against respiratory syncytial virus: safety and pharmacokinetics. The RSVIG Study Group. 171 13