Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Swelling is a common chief complaint among patients. Swelling and hives are not typical of hereditary angioedema. Organ transplantation drugs are associated with angiodema and may complicate diagnosis. Our objective was to manage a complex case of angioedema in a setting of rashes and liver transplantation. We present an illustrative case of angioedema, rashes, and intussusception in a setting of a liver transplant and tacrolimus use with a family history of autoimmune disease. Treatment with the kallikrein inhibitor, kalbitor, eliminated angioedema and intussusception, though not permanently. Serial C1 esterase [corrected] inhibitor levels were only suppressed during severe attacks of angioedema. C1q autoantibody was elevated. Although 95% of cases of hereditary angioedema (HAE) have low [corrected] C4 levels, those with C1q immune complexes have autoantibodies leading to low-grade inflammation and eventual consumption of C1 esterase inhibitor levels with C4 unaffected. Rashes associated with angioedema are not urticarial. Physicians should learn to recognize the signs of attacks of HAE.
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PMID:Angioedema in a child with a liver transplant, intussusception, and normal c4 levels. 2061 76

Anaphylactic food reaction often involves gastrointestinal symptoms, such as vomiting and abdominal pain, but to date, there have been no publications documenting the association between food hypersensitivity and intussusception. Herein is reported the case of a 2-year-old boy with intussusception accompanied by anaphylactic food reaction. The patient without known allergies complained of severe abdominal pain following ingestion of salmon roe for the first time. Dyspnea, wheezing and generalized urticaria also developed. Subsequently, he had stools containing jelly-like blood with mucus. At hospital arrival, physical examination identified an abdominal mass in the right lower quadrant; imaging confirmed the diagnosis of colo-colic intussusception. This patient was successfully treated with enema and no pathological findings were identified via radiology. Laboratory results supported the presence of IgE-mediated allergy to salmon roe in the present patient. To our knowledge, this is the first report to describe the possible association between intussusception and a hypersensitive food reaction.
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PMID:Intussusception secondary to anaphylactic reaction to salmon roe (ikura). 2413 55

In infants less than 2 years of age, acute hemorrhagic edema of infancy (AHEI) is characterized by the rapid onset of purpuric annular lesions associated with initially local edemas of the extremities. In most cases, this disorder is benign, without visceral involvement and diagnosis is based on clinical examination. There are no specific laboratory data and the histological analysis of these lesions (which is unnecessary in the majority of cases) is usually unspecific (the patient sometimes has an unspecified leucocytoclasic vasculitis). This condition is of uncertain nosologic status, mimiking rheumatoid purpura. Sometimes the patient had had rhino-pharyngeal episode in previous days, suggesting a viral cause. There is a clear discrepancy between the good general condition and the profuse and spectacular appearance of the lesions. Children's monitoring in the first days must be rigorous but complications are exceptional (acute intussusception'). Patient's outcome is marked by spontaneous regression within 12 days. Treatment is based on careful monitoring of the child's general status. Fever, purpuric lesions extension and, especially, signs of alteration of the general state may suggest the diagnosis of purpura fulminans. Another differential diagnosis is acute hemorrhagic or ecchymotic urticaria. We report the case of a 3-month old infant with diffuse pseudo-roundel like lesions in a context of apyrexy and preservation of the general state. Patient's outcome was favorable, without receiving any treatment. This confirm the diagnosis of AHEI.
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PMID:[Acute hemorrhagic edema of infancy]. 3169 96

In infants less than 2 years of age, acute hemorrhagic edema of infancy (AHEI) is characterized by the rapid onset of annular purpuric lesions associated with initially localized edemas affecting the extremities. This disorder is usually benign, without visceral involvement. Diagnosis is based on clinical examination, no specific laboratory findings exist and the histological examination of the lesions (which is unnecessary in the majority of cases) is most often nonspecific (sometimes patients have nonspecific leukocytoclastic vasculitis). Nosological status of AHEI remains unclear, but some reports suggest it is a clinical manifestation of rheumatoid purpura. Rhinopharyngeal episodes in the days before its onset have sometimes been reported, suggesting a viral cause. There is a net mismatch between patient's good general condition and the remarkable dissemination of the lesions. Infants monitoring must be rigorous in the first days, even though complications are exceptional (acute intussusception). Patients recover spontaneously within 12 days. Therapeutic management is based on accurate monitoring of the infant's general status. Fever, the extension of the purpuric lesions and, in particular, signs of impaired general condition may suggest the diagnosis of purpura fulminans. Another differential diagnosis is acute hemorrhagic or ecchymotic urticaria. We here report the case of a 3-month old infant with diffuse pseudoannular lesions within a context of apyrexy and preservation of patient's general condition. Patient's outcome was favorable without any treatment, confirming the diagnosis of AHEI.
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PMID:[Acute hemorrhagic edema of infancy]. 3169 2