Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chronic urticaria is a relatively common disease with no known etiology. It does not appear to be a classic allergic reaction, and whether it has an immunologic component is not known. The diagnosis is one of exclusion: In particular, underlying disease, drug reaction, and food allergy must be ruled out. Treatment aims at relief of symptoms rather than suppression of the urticaria, and consists mainly of use of antihistamines supplemented with corticosteroids when necessary. The side effects of antihistamines are minor, and the dosage of corticosteroid used and length of time it is given are small enough to avoid major side effects.
 ...
PMID:Chronic urticaria. Possible causes, suggested treatment alternatives. 613 55

Specific food intolerance needs to be distinguished from obsessional states in which those who are affected have an aversion to numerous foods. Even in cases where specific food intolerance can be demonstrated, the diagnosis of food allergy depends on additional evidence that the patient's reaction is based on an abnormal immunological response. In food allergy, skin and laboratory tests may detect the presence of an IgE-mediated reaction, particularly in patients with asthma or eczema and especially where the foods involved are highly allergenic--such as egg, fish, nuts and milk. However, many patients with proven food intolerance have negative tests, suggesting that other immunological or non-immunological mechanisms are responsible. Laboratory tests for non-IgE reactions are unreliable. Where it is difficult to show a connection between individual foods and an allergic response--as in patients with urticaria provoked by food additives--one of the reasons for diagnostic difficulty is that the offending substances may be present in a wide range of common foods. If the diagnosis is to be firmly established in such cases, it is necessary to show that symptoms remit on an elimination diet and recur after a placebo-controlled challenge.
 ...
PMID:Food intolerance and allergy--a review. 635 Nov 51

Among 1.000 consecutive cases of urticaria with suspicious food history and positive oral exposition, 12 patients showed an acute recurrent course. The result of the Prick or rub test was mainly positive in analogy, the RAST later determined in 5 of these patients remained four times "false negative" to the rub test in 4 of 5 allergens. Many of these patients complained of typical mucosal prodromes immediately on oral exposition, which are apparently pathognonomic of food allergy. In another 13 patients, the clinical reaction was limited to oral symptoms without generalized urticaria, in spite of corresponding history and skin tests; therefore, it was regarded as "forme fruste anaphylaxis". In these cases RAST was performed together with the Prick or rub test; seven times it corresponded with the oral exposition, five times it remained negative. In correspondence with the Prick test it was five times positive and two times negative; it remained "false negative" to 9 allergens. Remarkable in this group was the coincidence of positive apple RAST and strongly positive birch pollen allergy in the form of rhinitic or asthmatic symptoms and atopy. Among 72 patients with chronically-recurrent urticaria and no suspicious history, however, there was only one case of nutritive allergy demonstrated by means of elimination and provocation diet and a subsequent "super meal". On the other hand, pseudoallergic intolerance reactions (of the aspirin type) to food additives were demonstrated in 14 out of 300 patients with chronic urticaria my means of systematic oral provocation. Therefore, in cases of chronic urticaria with no suspicious history, there is no much use in searching for a nutritive allergen by means of elimination or provocation diet, in contrast to the intolerance diagnosis by certain "test batteries". In total, the rate of secured food allergies in patients with urticaria (without "forme fruste anaphylaxis") was approximately 1.5%, the rate of pseudoallergic reactions to food additives was 4.7%. Taking together all cases, an involvement of causative or partly causative food components was demonstrated in 8.6%.(ABSTRACT TRUNCATED AT 400 WORDS)
 ...
PMID:[Allergic and pseudoallergic reactions of the urticaria skin and mucous membranes due to food components with special reference to food and RAST]. 646 26

Cord serum IgE levels were examined in 101 newborn infants of atopic parents, and reviewed at the ages of 3, 6, 9, 12, 15, 18, 21 and 24 months, in order to determine any relation with signs and symptoms of allergic rhinitis, bronchial asthma, atopic dermatitis, urticaria and food allergy. Cord blood IgE levels were 1.06 +/- 1.02 U/ml in the group of infants who developed atopic disease, and 0.34 +/- 0.79 U/ml in the group of infants who did not develop atopy (P less than 0.001). In the breast-fed group 37.5% of the infants with cord blood IgE more than 0.8 U/ml and 11.5% with IgE below 0.8 U/ml had atopic disease. In the soy-fed group 33.3% of the infants with cord blood IgE more than 0.8 U/ml and 15.8% with cord blood IgE less than 0.8 U/ml developed atopy. Ninety percent of the cow's milk-fed infants with cord blood IgE above 0.8 U/ml and 16% with cord blood IgE below 0.8 U/ml showed atopy during the follow-up period. No correlation was found between the IgE levels in maternal and respective cord blood.
 ...
PMID:Predictive value of cord blood IgE levels in 'at-risk' newborn babies and influence of type of feeding. 668 83

We report 8 infants with immediate hypersensitivity reactions to foods (milk, egg, or peanut), occurring at the first-known exposure. Each developed symptoms within the first hour, but these generally settled within 2 hours. Sensitisation to the food concerned was demonstrated by positive immediate allergen skin prick tests in every case. Symptoms experienced included irritability, erythematous rash, urticaria, angio-oedema, vomiting, rhinorrhoea, and cough. Five infants were being followed prospectively and 4 were clinically tolerant of the food by age 16 months. The most likely route of sensitisation was via breast milk. None of the infants experienced similar reactions while being breast fed, suggesting that the reaction was dose dependent. As 5 out of a group of 80 infants being followed prospectively developed an immediate reaction at their first known exposure to a food, this appeared to be a not uncommon presentation of food hypersensitivity in infancy.
 ...
PMID:Immediate food hypersensitivity reactions on the first known exposure to the food. 684 27

Allergic features of 38 patients with allergic bronchopulmonary aspergillosis (ABPA) were reviewed. These features included skin reactivity to other inhalant antigens and to molds other than Aspergillus fumigatus (Af) plus clinical manifestations of rhinitis, conjunctivitis, asthma, eczema, urticaria, anaphylaxis, food allergy, and drug allergy. ABPA patients have a high degree of allergic reactivity in all these clinical features, in particular, clearly documented food allergy. These findings differ from those previously reported in ABPA patients in England, where it was noted that patients with ABPA whose asthma began after age 30 had few manifestations of other allergic diseases. By contrast, our patients in the same age group (onset of asthma after age 30) had the same multiple allergic manifestations as younger patients. These results show that ABPA patients are a subset of atopic individuals with a greater predisposition for the development of a wide spectrum of allergic diseases, despite the lack of manifestations of other major immunologic disease patterns.
 ...
PMID:Immediate-type reactions in patients with allergic bronchopulmonary aspergillosis. 685 23

We retrospectively studied 94 children with urticaria longer than six weeks in duration. The disease was equally distributed among the sexes and the following age subgroups (0-3.9 years, 4.0-7.9 years, 8.0-11.9 years and 12.0-15.9 years). A cause of the urticaria was identified or suspected in 15 of the patients. These included eight patients with cold urticaria, two with infection (hepatitis, sinusitis), two with food allergy, one patient with juvenile rheumatoid arthritis, one with arthralgia associated with a positive ANA and one with a low level of total hemolytic complement (CH50). Follow-up of a year of more on 52 patients revealed a median duration of urticarial symptoms of 16.0 months, with 58% of children becoming symptom free for six months or more, whereas the remaining 42% continued to have recurrent symptoms but without the development of an underlying serious illness. Results of the present study indicate that the etiology of chronic urticaria in childhood remains mostly undetermined but that the prognosis is generally favorable. However, one must consider an underlying infection or autoimmune disease as a potential etiology.
 ...
PMID:Chronic urticaria in childhood: natural course and etiology. 688 5

The clinical and laboratory features of 68 children with food intolerance or food allergy are reviewed. Young children were affected the most with 79% first experiencing symptoms before age 1 year. Forty-eight (70%) children presented with gastrointestinal symptoms (vomiting, diarrhoea, colic, abdominal pain, failure to thrive), 16 (24%) children with skin manifestations (eczema, urticaria, angioneurotic oedema, other rashes), and 4 (6%) children with wheeze. Twenty-one children had failed to thrive before diagnosis. A single food (most commonly cows' milk) was concerned in 28 (41%) cases. Forty (59%) children had multiple food intolerance or allergy; eggs, cows' milk, and wheat were the most common. Diagnosis was based on observing the effect of food withdrawal and of subsequent rechallenge. In many children food withdrawal will mean the use of an elimination diet which requires careful supervision by a dietician. Laboratory investigations were often unhelpful in suggesting or confirming the diagnosis.
 ...
PMID:Food intolerance and food allergy in children: a review of 68 cases. 713 62

From a representative group from the adult population (34.958) of a town of 77.384 inhabitants, 99 persons were selected who: a) claimed to be periodically dyspneic independently with respect to respiratory tract infections. b) had normal chest x-rays and normal PE flow values. Approximately one year later, a history of atopic diseases was taken from 79 of them, and intradermal skin tests were performed with some inhalants and food allergens. At this time, 15 persons failed to report their previous complaints of dyspnea. Only 5 persons reported that various vegetables and pickles were responsible for their urticaria or eczema. Only 2 persons admitted various gastrointestinal symptoms, but non mentioned milk, eggs or cereals as possible causative agents of their bronchial, nasal, skin or circulatory symptoms. Distinctly positive immediate type skin reactions to the mixed milk and egg allergen were recorded in 19 patients (24%), and to cereals in 11 persons (14%). They all reacted strongly also to the house dust allergen, but they did not differ from all the remaining subjects in the intensity of their skin response to the control solution of histamine. People with positive skin reactions to cereals or dairy products complained of chronic or recurrent rhinitis much more often than the others (73% and 63% compared with 35%). Forty-five (47%) of them had a positive personal history of urticaria or eczema. These "food reactors" did not differ from "non reactors" in the frequency of the elevated serum IgE level which was raised in 66% of the whole group (of 79). The results suggest that allergy to cereals and dairy products may often be underestimated in adult asthmatics especially when positive reactions to inhalants are also present. The problems of reliability of the skin tests and history taking in food allergy are briefly discussed.
 ...
PMID:Allergy to cereals and dairy products in adult, uncomplicated asthma: an epidemiological survey. 721 28

One hundred patients who reacted adversely to one or more specific foods were studied. In 93 the food induced symptoms included asthma, eczema, angioedema, urticaria, rhinorrhoea, or a combination of one or more of these with gastrointestinal symptoms. The remaining seven had gastrointestinal symptoms only. The diagnosis of food allergy was made on the on the basis of a definite, immediate allergic reaction to specific foods or a reaction that was suggestive of allergy, supported by a corresponding positive skin prick or radioallergosorbent test. In the absence of such evidence, the less specific diagnosis of 'food intolerance' seemed preferable. Test materials appeared to differ in their diagnostic usefulness. A high proportion (c. 75 per cent) of patients who were intolerant to egg, fish or nuts had positive test results. In contrast, only 30 per cent of patients with milk intolerance had positive tests, suggesting inadequate test methods or a non-allergic cause for many patients' milk intolerance. Nevertheless, five milk intolerant patients with negative tests had milk-induced asthma.
 ...
PMID:Food allergy and intolerance in 100 patients---local and systemic effects. 746 62


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>