Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042109 (urticaria)
 6,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Of 4087 women (aged 16 to 44 years old; 218 primigravida) subjected to induced abortion during the last 3 years, 762 (18.6%) developed complications. The complications were divided into three groups: group 1 included 64 women who developed complication within the first 7 days after abortion, group 2 included 46 women who developed complications within 7-30 days after abortion, and group 3 included 652 women with late complications. Of 64 women in group 1, 7 had perforation of the uterus, 28 had hematometra, and 29 has incomplete abortion. All 46 women in group 2 has endometritis. Of 652 women in group 3, 4 has placental polyps, 232 has inflammation with associated secondary infertility (hysterosalpingography indicated tubal obstruction in 194 and peritubal adhesions in 38), and 416 had disorders of the menstrual function. In addition to general clinical examination, 50 women with inflammation and tubal infertility underwent immunological examination and allergy testing. Of 50 patients, 35 were found to have skin rush, hives, drug or food hypersensitivity. The patients with allergy manifestations had marked inhibition of cellular immunity seen as decrease in T-lymphocyte count and 2 items increase in null lymphocyte count (B-lymphocyte count did not differ from that in healthy controls). The patients with tubal infertility received combined treatment. Conservative treatment including hydrotherapy, anti-inflammatory agents and electric stimulation was effective 123 of 232 women.
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PMID:[Analysis of the sequelae of induced abortion (based on the clinical data of the V.I. Lenin Kazan Institute for the Training of Physicians)]. 297 74

Imipenem-cilastatin was given in doses of 1 g intravenously every 6 h to 31 patients. Twenty-five patients, with 27 infections, were clinically evaluable and received 20 to 210 g of imipenem for a duration of 5 to 56 days (average 16.3 days). Infections included seven cases of osteomyelitis, seven of bacteremia, five of cellulitis, two of pneumonia, three of pelvic cellulitis, two of intraabdominal abscess, and one each of empyema, mediastinitis, and endometritis. Fifty-five percent of the infections were caused by gram-negative bacilli, 33% were due to gram-positive organisms, and 10% were caused by anaerobes. Twenty-two patients (81%) were cured, three improved, one relapsed, and one became superinfected with a resistant organism. In 5 of 11 cases with Pseudomonas aeruginosa, the imipenem MIC for organisms isolated by the end of treatment was higher than it was initially, raising concern that imipenem should not be used alone to treat Pseudomonas aeruginosa infections. Twenty-one patients had no adverse reaction; of the remaining 10 patients, 4 had nausea, 1 had urticaria, and 6 had mild abnormalities in hepatic function; three episodes of diarrhea included two with Clostridium difficile toxin in stool and one with pseudomembranous colitis, as determined by sigmoidoscopy. Levels of creatinine, hemoglobin, leukocytes, platelets, prothrombin, and urine components were unchanged. Imipenem-cilastatin is a clinically effective antibiotic with freedom from nephrotoxicity and hematological abnormalities in the large doses used in this study.
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PMID:Safety and efficacy of high-dose treatment with imipenem-cilastatin in seriously ill patients. 386 Jan 87

Although copper sulfate can cause systemic contact dermatitis, few such cases have been recorded among copper-releasing IUD users. Reported in this paper is a case of endometritis and urticaria-angioedema syndrome in a 32-year-old user of a copper IUD. Widespread urticaria, as well as angioedema of the eyelids and the labia majora and minora, persisted for about 6 months and were not responsive to corticosteroids and H1-antagonists. Copper sulfate positivity was demonstrated in 72-hour patch test, 48-hour application of the copper spiral to forearm, and in vitro lymphocyte-stimulating test. Histologic examination of the endometrial biopsy revealed vulvovaginitis with hyperplasia of the cervical canal and T-cell and eosinophilic granulocyte infiltration. Removal of the IUD caused complete symptom remission. In experimental animals with a radioactively labeled copper IUD, small amounts of copper sulfate are absorbed through the mucus membrane and carried to the cutis through the blood or lymph. In the cutis, the allergen is intercepted from antigen-presenting cells and recognized by T cells that migrate to the lymph nodes with blastic transformation, proliferation of cytotoxic lymphocytes, and cytokine production.
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PMID:Systemic contact dermatitis to copper-containing IUD. 889 20