Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0041296 (tuberculosis)
 76,850 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Infections of mice with Mycobacterium leprae in one rear foot pad immunized them against a second infection in the other rear foot pad. Purified bacilli harvested from the first infection also produced immuniy when injection into the foot pads of previously uninfected mice. Injections of BCG afforded similar protection, but had no adjuvant effect on M. leprae. M. duvali, a cultivable mycobacterium that is reported to be more closely related antigenically to M. leprae than BCG is, provided much less protection against M. leprae challenge than BCG did. Moreover, when M. duvali was mixed with BCG, it was not any more effective than BCG alone. Graft-versus-host reactions, induced by injections of parental spleen cells into F1 hybrids, provided no protection against M. tuberculosis and M. marinum challenge. They gave moderate protection against M. leprae in one experiment but not in another with a different schedule. Allogenic spleen cells had a protective effect when injected locally into the infected foot pad. The effect produced by these injections of spleen cells was a delay in the appearance of bacterial growth; however, there was no decrease in the rate of logarithmic growth when it did appear and no reduction in the eventual plateau level.
 ...
PMID:Immunity to Mycobacterium leprae infections in mice stimulated by M. leprae, BCG, and graft-versus-host reactions. 1 Nov 89

Material from 334 consecutive autopsies on Orang Asli subjects performed in the University Hospital, Kuala Lumpur between May 1967 and June 1978 was examined for amyloidosis. Nine positive cases were found, all in patients above 40 years of age, giving an age-corrected incidence of about 9%. In 6 cases, amyloidosis was probably secondary to tuberculosis. The remaining 3 cases exhibited a pericollagenous distribution characteristic of primary amyloidosis. Involvement of the heart and lungs was prominent. However, there were considerable similarities in the distribution and staining properties of the amyloid in the 2 groups. Though both the heart and kidney were frequently affected, the kidney was the most common organ to give rise to clinical symptoms. Infection probably plays a major contributory role in amyloidosis in the Orang Asli.
 ...
PMID:Amyloidosis in Malaysian aborigines (Orang Asli). 9 39

1. All essential attributes of the amyloidosis in aged persons ("senile amyloidosis") correspond to the condition which in younger individuals develops after infections, particularly following tuberculosis and lymphogranulomatosis, as so-called secondary amyloid degeneration, and also manifests many features of the so-called primary amyloidosis, not connected with infections. 2. Amyloid depositions in the brain, cardiac muscle, and in pancreatic islets (the "senile amyloidotic triad") dominate the morbid anatomic aspect. However, we know no organ or tissue which necessarily remains spared. The number of involved organs and tissues, in general, increases with the progressive aging of the patients. In those persons living long enough, amyloidosis affects every individual and probably all organs and tissues. 3. Contrary to the so-called secondary amyloidosis, in many cases of senile amyloidosis the spleen, liver and kidney remain intact. 4. In the so-called Alzheimers disease, in which both clinically and pathoanatomically a particularly destructive cerebral amyloidosis in relatively young persons prevails, just as in the common senile dementia of aged persons, the brain condition is associated with a systemic amyloid degeneration of many other organs. 5. Several cerebral and cardiac lesions due to amyloid accumulations can probably be diagnosed electrographically. Thus, through these already known morbid anatomical observations we have the promise of an essential enrichment of diagnostic perspectives. 6. In general, the etiologic manifoldness of amyloidosis presently seems to be incomparable. Infections, ionizing radiation, traumatic lesions in human pathology, the introduction of chemically definable substances, infections, and stress consequent to social burdening, proved effective in spontaneous and experimental amyloid degeneration of animals. 7. The demonstration of a tuberculous infection with the help of postmortem radiographs, as well as with the employment of histologic and microbiologic procedures to provide the evidence of acid fast bacilli in calcified remnants of pulmonary foci, proved to be eminently successful methods in the exploration of causes of senile tuberculosis and amyloidosis: Tuberculosis, after its invasion of the organism in early childhood, with its toxic and immunobiologic influences, holds it under its spell for an entire, even very long life and can be considered the most frequent cause of senile amyloidosis. 8. Chromosomal disturbances, with their hereditary manifestations, or, as in cases of mongoloid idiocy, associated with individual deformations, may present as amyloidoses. 9. Amyloid deposits in human pathology may develop by the transformation of normal structures, like cartilage, osteoid tissue, vascular elastic fibers, and also from scar hyalin and from fibrin. 10. We observed the disappearance of cerebral and cardiac amyloid accumulations producing typical defects. 11. Amyloidosis represents one of the most frequent spontaneous diseases of animals...
 ...
PMID:[Amyloidosis as a manifestation and origin of presenile and senile degeneration]. 13 66

1436 young men were investigated clinically and radiologically for rheumatic sacro iliitis. In two men (1.4%) definite bilateral sacro iliitis was diagnosed. In 18 cases (12.5%) the signs were not sufficient to make a definite diagnosis. They were regarded as suspected iliitis. For comparison the cards of 6138 patients who had called at our outpatient clinic over a 5 years' period were checked. In 40 cases (0.65%) a definite diagnosis of bilateral sacro iliitis was made, in another 45 cases (0.73%) sacro iliitis was suspected, but definite proof was lacking. The group we investigated has two characteristics. As to sex and age our test subjects (recruits) represent a group in which bilateral sacro iliitis appears relatively often. Infections are reported to increase the frequency of bilateral sacro iliitis. Our test subjects were only investigated for tuberculos infection. Active tuberculosis was not found. Also factors which may have a negative influence on the frequency were investigated. First of all the soldiers had been examined by clinical committees before recruitment. Advanced and thus clinically typical cases were eliminated by these committees and the frequency rate in the remaining group thereby decreased. The recruits came from very different parts of the country and various geographic and social factors may influence the morbidity. The frequency rates obtained at the end of the investigation have therefore to be regarded as the result of various factors some with positive and some with negative influence.
 ...
PMID:[Epidemiology of rheumatic syndromes in Turkey. III. Incidence of rheumatic sacro-iliitis in men of 20-22 years]. 30 50

Routine monitoring of serum levels is imperative when antibiotics are given to patients with impairment of renal function. Other desirable indications include: need for assessment of adequate aminoglycoside levels in the initial management of severe infection; chloramphenicol therapy; need for control of bioavailability of new drugs or of new derivatives of known compounds; specific clinical situations (unexplained therapeutic failure, assessment of the oral use of antibiotics as an adequate therapy in patient with severe infections; appraisal of the innocuity of topical antibiotics in burned patients or in patients with liver or renal insufficiency). The serum antibacterial test is highly recommended for assessing the adequency of antibiotic therapy in patients with bacterial endocarditis and in infected patients with impaired host resistance such as those with leukopenia. Control of initial treatment in any severe infection, osteomyelitis (particularly when combined antibiotics are used) and tuberculosis are other indications of this test. Any attempt to correlate the results yielded by antibiotic assays with in-vivo effectiveness must take into account the patient himself and the several unknown factors which, in each individual case, can affect the ultimate result of the antibiotic therapy, such as antibiotic delivery to tissues, drug binding to cellular debris, intracellular penetration of the antibiotic, etc.
Infection 1978
PMID:Indications, interpretation and applications of antibiotic assays. 35 46

In our sphere of life the picture of tuberculosis has altered. Infections in children have become less severe and considerably rarer. The chronic tuberculosis of age is decreasing. The reasons for the change in the course of tuberculosis are to be found in an increasing power of resistance of the body produced by better social hygienic conditions, a better immunological defense and the institution of modern therapy. Tuberculosis should only be subdivided into primary and post-primary stages with the possibility of spreading through local progressiveness to lymphadenobronchogenic and hematogenic pathways.
 ...
PMID:[Changes in the Conception of the Course of Tuberculosis: (author's transl)]. 40 24

Transtracheal puncture enables two samples of bronchial secretions to be taken-the product of transtracheal aspiration and simultaneously expectorated sputum (obtained in 71% of the cases)-for the purpose of testing for Mycobacterium tuberculosis in cases of suspected pulmonary tuberculosis. Two groups of patients were studied: Group I: 100 patients who were poor expectorators and who all underwent transtracheal puncture; Group II (Control): 100 patients who expectorated well or who had been given gastric lavages immediately on admission. Laboratroy analyses revealed M. tuberculosis in at least one of the samples obtained from each of the 200 patients. The authors compare the efficiency of the methods used within each group and between the two groups. Samples obtained by transtracheal aspiration and simultaneous expectoration (75% of positive results) more often contained M. tuberculosis than the other Group I samples (64% of total positive results; 64% of positive results for spontaneous sputa, 65% for gastric fluids), and as often as the Group II samples (76% of total positive results), particularly the expectoration samples (78% of positive results). Simultaneously expectorated sputum more frequently contained M. tuberculosis (82% of positive results) than transtracheal aspiration (69% of positive results). Transtracheal puncture and/or simultaneous expectoration were the only examinations revealing M. tuberculosis in 34 patients in Group I. Non-specific bacteriological findings are not relevant. However, the authors point out that this technique is not always innocuous (although no serious complications were observed in this series), and that transtracheal puncture must always be carried out by physicians trained in the technique.
Infection 1977
PMID:Usefulness of transtracheal puncture and aspiration in the bacteriological diagnosis of pulmonary tuberculosis. 41 Jul 34

One hundred consecutive cases of pulmonary infection due to Mycobacterium intracellulare-avium seen during a 3 1/2-year period qualified for review on the basis of a compatible chest x-ray film, repeated isolations from cultures of sputum, and follow-up of three to eight years. Infections with M intracellulare-avium represented 27 percent of all mycobacterial infections seen during this period, including those due to M tuberculosis. The cases of disease due to M intracellulare-avium were predominantly in men with preexisting pulmonary disease, with a peak incidence in the sixth decade, but nearly one-third of the cases were in younger persons free of coexisting disease. The disease was chronic and indolent in most cases, and only a few showed a progressive course. A stable course was frequently observed despite prolonged persistently positive cultures of sputum. A favorable prognosis was most often found in those with previously treated tuberculosis. Poor prognosis was often due to a serious associated disease, such as cancer, rather than to advancing mycobacterial infection itself. Age, sex, or race was unrelated to prognosis. Conversion to negative status on culture was attained in one-half of the cases. Those with extensive radiographic involvement or cavitation were more likely to have treatment fail bacteriologically. No combination of chemotherapy appeared to be particularly effective, including the use of five or more drugs in eight cases demonstrating progressive disease. Surgery, too, was ultimately disappointing in that recurrence appeared in six of 18 carefully selected cases.
 ...
PMID:Pulmonary mycobacterial infections due to Mycobacterium intracellulare-avium complex. Clinical features and course in 100 consecutive cases. 42 45

Infections of the spine usually involve the vertebral body and therefore by definition produce a kyphosis. Non-tuberculous infection usually staphylococcal and in the lumbar spine, is often diagnosed late and can involve the cord. Open exploration and stabilization with graft should therefore be considered. The destruction is usually less extensive and therefore the kyphosis less severe than in late neglected tuberculous infections. Tuberculous spinal infection accounts for 59% of all orthopedic tuberculosis. It invariably involves vertebral bodies and is progressive. Destruction of the bodies is by infection and avascular necrosis, kyphosis is inevitable and cord compression a common threat. While L-1 is the most commonly affected body T-10 is statistically the most commonly associated with cord compression. The treatment of spinal tuberculosis should be aimed at correcting 5 basic defects associated with the disease and the deformity: mechanical instability; chronic smoldering infection; spinal cord and nerve root compression; disturbance of spinal growth; depressed lung function. The cornerstone to effective treatment for spinal tuberculosis is drug therapy and the anterior fusion operation. For the established tuberculous kyphosis, which is always a fixed deformity, multiple staged operations and gradual correction used the Halo-pelvic apparatus is the best treatment available at present.
 ...
PMID:Kyphosis secondary to infectious disease. 59 76

Infection of two renal transplant recipients with tuberculosis is reported. Autopsy findings are available in one case. The frequency of tuberculosis in such cases, treatment problems and prevention are discussed.
 ...
PMID:Tuberculosis in renal transplant patients. 78 70


1 2 3 4 5 6 7 8 9 10 Next >>