Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0040822 (tremor)
 18,428 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Tiapride was applied to 25 mostly alcoholic patients affected by tremor, agitation and psychic disorders, with favourable results in more than half cases. By oral or parenteral way, efficacy is the same and the minimal active dose may be fixed at 300-400 mg/24 h. The treatment is well tolerated.
Sem Hop
PMID:[Interest of tiaprid in chronic ethylism and psychic disorders (author's transl)]. 3 22

The authors have experimented tiapride in 37 cases of abnormal movements and 20 cases of shaking anxio depresive origin. The best indication of tiapride corresponds to lingual buccal an facial dyskinesia caused by neuroleptics and senile trembling increased by alcoholism. On the other hand its anxiolytic and anti shaking properties are more limited. Finally in the case of degenerative senile trembling its action is less effective. Tolerance to tiapride seemed to be excellent even at high dose.
Sem Hop
PMID:[Abnormal movements and shaking in geriatrics (author's transl)]. 3 13

Triapride has proved to be effective for the treatmentof neurological and digestive disorders associated with chronic alcoholism. The clinical and physiopathological aspects of this disease are discussed briefly. Tiapride has a significantly effective action on tremor and muscular pains in moderate cases of alcoholism.--It corrects changes in hebanour and mood.--It improves appetite stimulating the desir for food and reducing the overall functional symptomatology. Tiapride is well-tolerated and vigilance is not modified.
Sem Hop 1978 Apr
PMID:[Nervous and digestive manifestations in chronic alcoholism. Their treatment by tiapride]. 21 May 20

Thirthy-three alcoholics, aged between 31 and 82 years, were treated for 7 to 30 days with tiapride. The dosage was 600 mg/day (200 mg 3 times daily) by mouth or 100 to 800 mg/day I.M. Out of 27 cases of tremor treated, there were 25 favourable results, one average result and one nil result. Insomnia and character disorders, e.g. anguish, depression, nightmares, hallucinations, were improved during the first few days of treatment in 27 cases out of 30. Out of 12 cases of algo-paresthesia of the lower limb treated, the were 9 good or excellent results, 2 average results and 1 nil result. A favourable result was observed in 7 cases out of nine in vomiting, water brash (3 cases out of 4), and in 16 cases out of 20 in anorexia. No clinical or laboratory disturbance attributable to tiapride was noted in our patients whose general health was often very poor.
Sem Hop 1978 Mar
PMID:[Tiapride and alcoholic disorders of central origin. Apropos of 33 cases]. 21 35

The therapeutic action of Tiapridal appeared to the authors particularly precious and constant in delirium tremens, senile agitation and turbulence, whatever the origin, and bucco-linguo-facial dyskinesia, whether the latter were linked to age or whether they formed part of a neuroleptic syndrome. Their experience does not permit them to have any opinion concerning the use of this drug in tremor and chorea, the patients seem to respond favourably to treatment but in an erratic manner. On the other hand the drug was totally inefficacious in patients suffering from spasmodic torticollis and writer's cramp. Finally, it seemed to them useful to emphasise the improvement in comfort in patients suffering from various pains when given Tiapridal. This justifies the place given to Tiapridal among drugs necessary for the daily practice of neurology.
Sem Hop
PMID:[A new therapeutical approach in neurology (author's transl)]. 21 5

Thirty-three patients presenting an extra-pyramidal pathology with important involuntary movements have been treated with tiapride. The main beneficial results have been obtained in Huntington's chorea and in certain types of myoclony. The association with L-dopa, must be discussed. Only some L-dopa induced dyskinesias are improved; moreover tiaprid may antagonize L-dopa. The essential familial tremor is never improved.
Sem Hop
PMID:[Therapeutical approach to involuntary movements (author's transl)]. 21 37

A total of 24 patients (20 men and 4 women) were treated for varying degrees of alcoholism. Tiapride was administered orally as 300 to 600 mg/day to 22 patients, the other two cases receiving i.v. injections followed by oral doses. Tiapride was extremely well-tolerated and no side-effects were noted. Withdrawal symptoms were effectively reduced, and a significant action was noted against tremor. Tiapride was also effective against depression and anxiety, and hallucinations disappeared in two cases.
Sem Hop
PMID:[Treatment of alcohol withdrawal symptoms: a clinical study (author's transl)]. 22 18

Alcoholism is the number-one social scourge in France today and any means that become available for combating its effects are of the utmost importance. The author used an original approach to the problem by obtaining the co-operation of the family doctors in order to study 60 cases, including 52 men and 8 women, with alcoholism. Clinical symptoms, drinking habits, and in some cases biological test results using Gamma GT were recorded. The patients were then treated with tiapride. Daily family, professional and social activities were always better after treatment with extension of ideation and improved relations with others. Tremor was also greatly diminished. Distate for alcohol was not observed constantly but in some rare cases. Total abstinence was only noted in one case, but reduced alcohol consumption was reported in 50% of the patients. It is true that the product was not associated systematically with psychotherapy which might have made the results more demonstrative, but the objective of the study was to evaluate whether tiapride could be of value by assisting in the fight against alcoholism, and this was confirmed.
Sem Hop
PMID:[The fight against alcoholism and its consequences in general practice (author's transl)]. 22 66

From the analysis of 115 cases of primary generalized epilepsies treated for a mean duration of 43 months with sodium valproate as sole therapy, it appears that: the mean effective daily dosage is 21 mg/kg; the efficacy of valproate proved excellent in 82.6% of cases (seizures fully controlled: 74%, seizures occurring exceptionally: 9%); a loss of activity was never observed; in these circumstances of prolonged administration of the drug, no signs of major intolerance were seen; side-effects occurred in 29% of cases, including 20% long-term effects (weight gain, essential tremor); 64 series of laboratory tests including 15 parameters made it possible to evaluate the hematological, hepatic and pancreatic tolerance of valproate: the majority of the tests were normal. The authors believe that during long-term therapy with valproate, monitoring does not need to include the routine performance of liver function tests, but that it would be more advisable, should a suggestive clinical sign be noted, to investigate the platelet count, coagulation (partial activated thromboplastin time) and protein synthesis (fibrinogen).
Sem Hop 1983 Apr 21
PMID:[Monotherapy with sodium valproate in generalized primary epilepsy. 2d phase: Study of long-term efficacy and tolerance]. 619 93

The effects of two beta-blockers, one non-selective, propranolol, the other beta 1 selective, metoprolol, were studied in 8 asthmatic patients. Practolol and a placebo were used as reference products. Heart rate, blood pressure, MEV, and muscle tremor were measured at rest and after isoprenaline infusions at different concentrations. In patients receiving placebo, isoprenaline caused an increase in heart rate, MEV, systolic BP, and muscle tremor, and a reduction in diastolic BP. After propranolol, the effects of isoprenaline on heart rate, MEV, and muscle tremor were almost completely blocked, and modifications in systolic and diastolic BP were only slightly affected. Metoprolol and practolol did not inhibit the increase in MEV induced by isoprenaline, but they reduced the increase noted in the heart rate. These results demonstrate the beta 1 selectivity of these two beta-blockers. Contrary to propranolol, metoprolol and practolol did not block the increased muscle tremor provoked by isoprenaline: muscle tremor must be dependent on beta 2-receptor activity. As the effect of isoprenaline on the MEV was not inhibited by beta 1-selective beta-blockers, these can be prescribed for asthmatic patients in association with beta 2 stimulants.
Sem Hop
PMID:[Effects of metoprolol, practolol, and propranolol after isoprenaline injections in asthmatic patients (author's transl)]. 624 20


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