Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0040822 (
tremor
)
18,428
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Four open-label studies have reported beneficial effects of clozapine on the
tremor
of idiopathic Parkinson's disease (PD). We performed a double-blind crossover trial with a 2-week washout, comparing low-dose clozapine to benztropine for the treatment of
tremor
in PD. Twenty-two subjects enrolled and 19 completed the study.
Benztropine
and clozapine were equally effective in improving
tremor
and the motor score of the United Parkinson's Disease Rating Scale at mean doses of 3.0 and 39 mg/day, respectively. Significant adverse events were experienced with each drug, but leukopenia was not encountered. We conclude that the atypical antipsychotic drug clozapine is helpful in the treatment of
tremor
in PD and should be considered when all other drug therapies fail.
...
PMID:Benztropine versus clozapine for the treatment of tremor in Parkinson's disease. 910 3
