Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0040822 (
tremor
)
18,428
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The activity of the new original compound--hydrochloride N-2-(adamantyl) hexamethylenimine (code
A-7
) synthesized at the Institute of Pharmacology, Russian Academy of Medical Sciences, was studied on models of akinetic-rigid and
tremor
manifestations of the parkinsonian syndrome.
A-7
completely relieves the akinetic-rigid manifestations of the syndrome and surpasses mydantan and L-dopa in antagonism with haloperidol and triftazine. Just as L-dopa, cyclodol, and mydantan,
A-7
alleviates reserpine-induced oligokinesis and restores body temperature which is lowered by reserpine.
A-7
possesses evident antitremor activity which advantageously distinguishes it from mydantan which failed to demonstrate antagonism with arecoline.
A-7
is promising for further study as a potential agent for the treatment of parkinsonism.
...
PMID:[The antiparkinson activity of a new adamantane derivative]. 1051 25
A new antiparkinsonian drug, N-(2-adamantyl)hexamethyleneimine hydrochloride (
A-7
), was studied on the model of parkinsonism syndrome (PS) induced by MPTP neurotoxin.
A-7
(5-20 mg/kg) attenuated the MPTP induced akinesia and rigidity manifestations in C57B1/6 mice, the effect being more pronounced than that of cyclodol and levodopa and comparable to that of midantane (amantadine).
A-7
also decreased the PS manifestations in rats: removed
tremor
, rigidity, and oligokinesia, normalized the MPTP-violated bioelectrical activity of nucleus caudatus, sensomotor cortex, and dorsal hippocamp, and eliminated pathologic slow activity, paroxysmal discharges, and high-frequency activity discharges. The activity of
A-7
exceeded that of levodopa (enhancing
tremor
) and cyclodol (not eliminating the pathologic slow activity).
...
PMID:[Effect of the novel aminoadamantane derivative A-7 on Parkinsonian syndrome induced by systemic administration of neurotoxin MPTP]. 1093 86
