Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0040822 (tremor)
 18,428 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The cardiovascular and behavioral actions of cimetidine, injected into the lateral ventricle, were studied in conscious, freely moving rats. Cimetidine produced a dose-dependent pressor response accompanied by decreases in heart rate and increases in pulse pressure. At doses of 25-100 micrograms, cimetidine produced sedation; however, when 200 micrograms was injected, tremor was observed in all animals. If cimetidine was administered twice within 30 min to the same animal, tachyphylaxis in response to any of these actions was never evident. Although histamine produced similar pressor actions when administered intraventricularly, these effects were always subject to tachyphylaxis. The actions of cimetidine were not altered by central pretreatment with the H1 antagonist chlorpheniramine. A possible hypothesis of the central mechanism by which cimetidine produces these effects is discussed.
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PMID:Cardiovascular and behavioral actions of centrally administered cimetidine. 620 9

The serotonin toxicity (ST) is a potentially life-threatening adverse drug reaction results from therapeutic drug use, intentional self-poisoning, or inadvertent interactions between drugs. ST can be caused by a single or a combination of drugs with serotonergic activity due to excessive serotonergic agonism on central nervous system and peripheral serotonergic receptors (monoamine oxidase inhibitors, tricyclic antidepressants, SSRIs, opiate analgesics, over-the-counter cough medicines, antibiotics, weight-reduction agents, antiemetics, antimigraine agents, drugs of abuse, H2-antagonist and herbal products). The serotonin toxicity is often described as a clinical triad of mental-status changes (agitation and excitement with confusion), autonomic hyperactivity (diaphoresis, fever, tachycardia, and tachypnea), neuromuscular abnormalities (tremor, clonus, myoclonus, and hyperreflexia) and, in the advanced stage, spasticity; not all of these findings are consistently present. In this article, we describe two cases of ST due to interaction between Citalopram and two CYP2D6 inhibitors: Cimetidine and Topiramate and their clinical resolution after treatment discontinuation.
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PMID:Serotonin toxicity: a short review of the literature and two case reports involving citalopram. 2149 Oct 99