Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0040822 (tremor)
 18,428 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rhesus monkey models of Parkinson's disease were induced by injection of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neural firings were recorded using microelectrodes placed in the internal segment of the globus pallidus. The wavelets and power spectra show gradual power reduction during the disease process along with increased firing rates in the Parkinson's disease state. Singular values of coefficients decreased considerably during tremor-related activity as well as in the Parkinson's disease state compared with normal signals, revealing that higher-frequency components weaken when Parkinson's disease occurs. We speculate that the death of neurons could be reflected by irregular frequency spike trains, and that wavelet packet decomposition can effectively detect the degradation of neurons and the loss of information transmission in the neural circuitry.
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PMID:Reduced information transmission in the internal segment of the globus pallidus of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced rhesus monkey models of Parkinson's disease. 2562 34

The disabilities affecting the peripheral regions of the body can be often as a result of cerebellar damage. Tremor, poor and inaccurate coordination, and irregular movements associated with gait, balance and speech are some of the manifestations. Conventionally expert opinion determines severity of Cerebellar Ataxia (CA) and the assessment is likely to be inherently subjective. The automated versions of two commonly used tests: Finger to Nose test (FNT) and Heel to Shin Test (HST), are investigated in this paper for evaluating disability and movement deficits due to CA. Limb movements are measured using Inertial Measurement Units (IMU) that captures the disability related information, using kinematic parameters such as acceleration and angular velocity considered in both time and frequency domain. Using the Singular Spectrum Analysis (SSA), the collective dominance in the data distributions of the underlying features were observed. The dominant features were combined to substantiate the correlation with the expert clinical assessments through Linear Discriminant and Regression analysis where the classifier performance was also verified by means of cross-validation. This study found that IMU features captured characteristic movements as intention tremor in FNT and not in HST. In FNT predominantly consisting of translational movements, the rotation was a dominant feature whereas acceleration were observed to be more dominant for the case of HST.
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PMID:Quantitative Assessment of Cerebella Ataxia, through Automated Limb-Coordination tests. 3194 14