Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0040822 (tremor)
 18,428 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Zonisamide is a new antiepileptic drug which has a wide range of antiepileptic efficacy. This drug is becoming widely to be used for patients with refractory epilepsies. The author reports two patients who developed resting and postural hand tremor after administration of zonisamide. The tremor was confined to the upper extremities and was enhanced with the emotional stress. The tremor has 4-5 Hz frequency and was severe enough to disturb their daily activities. Mild cogwheel rigidity was seen, but neither akinesia nor gait disturbance was recognized. The symptoms disappeared completely after cessation of the drug. This side effect should always be kept in mind in the treatment with zonisamide.
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PMID:[Zonisamide induced tremor--report of two cases]. 156 87

Zonisamide (ZNS), a sulfonamide antiepileptic drug, is indicated as an adjunct therapy for partial seizure disorders with and without secondary generalization. ZNS has a favorable pharmacokinetic profile because of its rapid absorption and high bioavailability. Its activity is related to the blockade of voltage gated sodium and calcium channels, modulation of central dopaminergic, GABAergic, and serotonergic functions, as well as inhibition of carbonic anhydrase and monoamine oxidase B. ZNS has potential efficacy for an array of neuropsychiatric disorders including migraine and other headache syndromes, neuropathic pain, Parkinson's disease, essential tremor, stroke, obesity, anxiety, bipolar and binge-eating disorders.
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PMID:Therapeutic role of zonisamide in neuropsychiatric disorders. 1878 51