Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0040822 (tremor)
 18,428 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A patient with tremor associated with spasmodic dysphonia developed a marked exacerbation of her upper limb tremor whilst on co-careldopa (Sinemet CR) that improved when the drug was withdrawn.
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PMID:Levodopa can worsen tremor associated with dystonia. 1685 31

We present the case of a 78-year-old male who, 16 years ago, was diagnosed with Parkinson's disease (PD) by a neurologist. He initially presented with left-hand tremor, stooped posture, shuffling gait, and frequent falls, which eventually progressed to bilateral motor symptoms after 3 years. Since 2012, his symptoms and signs have almost completely remitted, and he has been off all pharmacotherapy for that time. The accuracy of the initial PD diagnosis is supported by an appropriate clinical presentation, history of positive response to Sinemet, and an abnormal SPECT DaT scan; thus this case suggests the possibility of remission of symptoms in some patients. We propose that the patient's long history of meditation practice may have been one contributing factor of this improvement as meditation has been shown to release dopamine in the striatum.
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PMID:A potential case of remission of Parkinson's disease. 2737 5

This study reports long-term (over 6 years) effect of controlled-release carbidopa/levodopa (CRCL, Sinemet-CR) in levodopa-naive Parkinson's disease patients. Parkinsonian features were evaluated utilizing the Northwestern University Disability Scale (NUDS) and modified New York University Parkinson's Disease Rating Scale (NYUPDRS). The NUDS scores showed significant variation over time by 2-way ANOVA (P < 0.0001). Following treatment, compared to baseline scores, the NYUPDRS scores showed significant improvement in rigidity, tremor, bradykinesia, while the postural stability scores worsened and gait scores, after initial improvement, returned to baseline level. At the end of the study period 5 patients were alive, 1 became disabled due to myocardial infarction and 3 were holding on to full time occupations. Three patients developed medication related dyskinesia, 1 developed myoclonus and 1 developed a combination of dyskinesia, motor fluctuations and early morning dystonia. Due to small number of patients, while a definite conclusion cannot be drawn, it appears that the incidence of motor fluctuation may be much less prevalent than dyskinesia in patients with Parkinson's disease treated with CRCL.
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PMID:Long-term effect of controlled-release carbidopa/levodopa in levodopa-na. 2950 14


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