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Query: UMLS:C0040822 (tremor)
 18,428 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Resting tremor is one of the major symptoms of Parkinson's disease, which causes havoc in motor functions of the body, has its genesis in communication impairments in the subthalamic nucleus of the basal ganglia. The modern sophisticated surgical treatments, including electrical deep brain stimulation do not yield satisfactory results due to their inability to provide long-term cure and minimize side effects, such as discomfort and increased infection rates. In this work, we propose a novel system based on the emerging communication technology of wireless optogenetic networks of neural dusts to provide a long-term solution for the alleviation of resting tremor. Interfaced with neural dusts, each of the subthalamic nucleus neurons can be controlled and stimulated by the ultrasonic waves which are transmitted from a single/multiple subdural transducer(s) that are placed in the dura mater of the brain. Moreover, in order to address the challenging tasks of charging and addressing each of the neural dusts, we propose a protocol, named as Single Time Instant addressing Protocol, which outperforms the state-of-the-art parallel charging protocol. The basic idea of our protocol is that it selects most frequently occurring spike patterns in a single time instant and assigns the pattern with an ultrasonic frequency. With the improved efficiency of Single Time Instant addressing Protocol validated with empirical datasets, the proposed system is expected to revolutionize the way of treatment of parkinsonian resting tremor.
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PMID:Long-Term Alleviation of Parkinsonian Resting Tremor Using Wireless Optogenetic Nanonetworks. 3216 4

Parkinson's disease (PD) is an alpha-synucleinopathy that leads to prominent motor symptoms including tremor, bradykinesia, and postural instability. Nonmotor symptoms including autonomic, neurocognitive, psychiatric symptoms, and sleep disturbances are also seen frequently in PD. The impact of PD on sleep is related to motor and nonmotor symptoms, in addition to the disruption of the pathways regulating sleep by central nervous system pathology. Rapid eye movement sleep behavior disorder is a parasomnia that can lead to self-injury and/or injury to partners at night. Restless legs syndrome is a subjective sensation of discomfort and urge to move the legs prior to falling asleep and can lead to insomnia and reduced sleep quality. Excessive daytime sleepiness is common in PD and exerts a negative impact on quality of life in addition to increasing the risk of falls. Obstructive sleep apnea is a breathing disorder during sleep that can cause frequent awakenings and excessive daytime sleepiness. Circadian rhythm dysfunction can lead to an advanced or delayed onset of sleep in patients and create disruption of normal sleep and wake times. All of these disorders are common in PD and can significantly reduce sleep quantity, sleep quality, or quality of life for patients and caretakers. Treatment approaches for each of these disorders are distinct and should be individualized to the patient. We review the literature regarding these common sleep issues encountered in PD and their treatment options.
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PMID:Sleep Issues in Parkinson's Disease and Their Management. 3302 23


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