Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0040822 (tremor)
 18,428 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. The actions of rimiterol [erythro(3,4-dihydroxyphenyl, 2-piperidyl methanol hydrobromide)], a new sympathomimetic bronchodilator, have been compared with those of salbutamol and laevoisoprenaline on the heart and lungs, and on contractions of the soleus muscle of cats under chloralose anaesthesia.2. Rimiterol and salbutamol injected intravenously were about equipotent in all tests, and were about 8 times less potent than laevoisoprenaline both in opposing the bronchoconstrictor action of 5-hydroxytryptamine, and in decreasing the tension and degree of fusion of incomplete tetanic contractions of the cat soleus muscle. They were about 19 times less potent than laevoisoprenaline in increasing heart rate.3. The effect on the soleus muscle is considered to be analogous to the muscle tremor that often occurs in man, and the results therefore suggest that systemic administration of bronchodilator doses of rimiterol, like salbutamol, may produce muscle tremor as an unwanted side-effect.4. When equipotent doses to oppose 5-hydroxytryptamine-induced bronchospasm were compared, rimiterol and salbutamol produced less tachycardia than did laevoisoprenaline. In order to match the tachycardia produced by laevoisoprenaline, the doses of rimiterol or salbutamol had to be increased about two and a half times. This safety margin for salbutamol in the cat is considerably less than that reported by others for different species, which suggests that beta(1)- and beta(2)-adrenoceptors may be less clearly differentiated in the cat than they are in other laboratory animals.
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PMID:Actions of the sympathomimetic bronchodilator, rimiterol (R798), on the cardiovascular, respiratory and skeletal muscle systems of the anaesthetized cat. 508 31

6 cases with tremor-athetotic type cerebral palsy and 2 cases with moderate dystonia-tremor type cerebral palsy were treated by selective stereotactic thalamotomy. In the former group, postural-movement type tremor in the upper limb gradually progressed with age while athetosis remained unchanged. In the latter group, dystonia in the truncal muscles predominated over the irregular tremulous movement of the upper limbs. In all cases, the intelligence was almost normal. Stereotactic selective thalamotomy (Vim for tremor athetosis, VL-Vim for dystonia tremor) was performed under local anesthesia with the aid of radiological and neurophysiological control methods. The results of the operations were satisfactory in regard to the tremor relief and concomitant improvement of motor performances in most of the cases. Stereotactic treatment might be an effective way to make possible a one-step progress in these handicapped cases. The importance of postoperative physical therapy is also emphasized.
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PMID:Stereotactic selective thalamotomy for the treatment of tremor type cerebral palsy in adolescence. 634 49

The 'Ether Pac' and 'Fluo Pac' temperature compensated vaporizers have been evaluated in the laboratory and the 'field'. Rigorous testing has demonstrated that these vaporizers are robust and reliable. Shaking, tilting and overturning do not significantly affect their performance. Both vaporizers deliver lower concentrations of the vapour than the setting on the vaporizers at low tidal volumes (100 ml). The 'Ether Pac' vaporizer output declines progressively with ambient temperatures below 23 degrees C and a similar result occurs with the 'Fluo Pac' at temperatures below 20 degrees C. Clinical trials in Nepal, Kenya, Burma and the UK have demonstrated that, when halothane is used, oxygen enrichment is necessary during spontaneous and controlled ventilation. When ether is used with controlled ventilation oxygen enrichment is probably not necessary even with ambient pressures as low as 619 mmHg.
Anaesthesia 1983 Sep
PMID:Evaluation of a new range of air drawover vaporizers. The 'PAC' series--laboratory and 'field' studies. 641 29

The efficacy of a simple practical training method for teaching local anesthesia is demonstrated by measuring the tremor of a student's hand giving his first injection. The method consists of self-training of the students using "special" needles and syringes.
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PMID:Psychological investigations in the undergraduate training for local anesthesia. 678 Apr 80

[14C] Verruculogen (75 micrograms/kg) was given intravenously to a sheep under barbiturate anaesthesia to prevent the severe tremor and convulsions which would otherwise have occurred. Two hours later 28 per cent of the tremorgenic mycotoxin was detected in the liver, bile and small intestine. Approximately 0.5 per cent was excreted in the urine. Trace amounts of radiolabel were detected in the cortex and corpus striatum of the brain. Verruculogen was metabolised by the liver and converted completely to four more polar products, including two isomeric forms of desoxy-verruculogen and the weakly tremorgenic mycotoxin TR-2. The principal and most polar metabolite excreted is probably an isomer of TR-2.
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PMID:Metabolism and excretion of [14C] verruculogen in a sheep. 710 Jun 51

A 51 years old patient underwent 3 urological operations within a short space of time. The anaesthetic procedures (NLA and spinal anaesthesia) caused a rise of temperature, hyperventilation and tremor, suggesting a malignant hyperthermia. The patient refused a muscle bioptical investigation. Biopsies were performed in the patient's children. In the daughter, some "whorled fibres" and single fibre necrosis, interpreted as signs of myopathy, were detected. The clinical syndrome of the father and the histological results of the daughter point out to the possibility that in this family a predisposition to malignant hyperthermia is present.
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PMID:["Malignant hyperthermia" following NLA and spinal anaesthesia (author's transl)]. 710 33

(S)-(+)- and (R)-(-)-5-Allyl-5-(1-methyl-2-pentynyl)-2-thiobarbituric acid (1, thiohexital) were prepared. The anesthetic activity (loss of righting reflex) and acute toxicity of the optically pure enantiomers of 1 were compared to the racemic isomer in mice. The S(+) isomer was found to be more potent as an anesthetic agent than the R(-) or RS(+/-) isomers. The therapeutic index was 2.5, 2.4, and 3.2 for the RS(+/-), R(-), and S(+) isomers, respectively. There were no significant differences in onset and duration of anesthesia when administered at the respective AD50 values. The prominent side effect is tremor, which is less for the S(+) isomer than for the R(-) or RS(+/-) isomers.
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PMID:Synthesis and pharmacological activity of thiohexital enantiomers. 732 85

This is a case report of an infant with shaken impact syndrome who required general anesthesia for the repair of pyloric stenosis. This infant suffered neurologic impairment from shaking, which was not only the major etiologic factor but the mechanism of injury as well. Shaking an infant can have devastating consequences. A thorough understanding of the mechanism of injury and the sequelae that result from this type of child abuse are paramount to prevent further damage if the infant requires general anesthesia. Anesthesia providers play a vital role in minimizing secondary injuries in infants with shaken impact syndrome.
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PMID:General anesthetic considerations for the infant with shaken impact syndrome and pyloromyotomy: a case report. 750 45

Endoscopic examination of the auditory tube diverticula was a diagnostic aid in the evaluation of 4 horses with otitis media/interna and associated osseous changes of the stylohyoid and petrous temporal. One of the horses was examined because of persistent head shaking; the other 3 were examined because of an acute onset of facial and vestibulocochlear nerve dysfunction. Proliferative lesions involving the petrous temporal bone and proximal portion of the stylohyoid bone were identified endoscopically in all 4 horses. Endoscopy is a noninvasive procedure that provides an alternative to skull radiography and tympanocentesis in the diagnosis of otitis media/interna in horses. In addition, risks associated with general anesthesia are avoided.
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PMID:Endoscopy of the auditory tube diverticula in four horses with otitis media/interna. 755 51

The incidence of shivering in women during epidural analgesia in labour is up to 33%, and may be highly distressing. Its mechanism is unclear, but the most widely held theory is that it is thermogenic. Pharmacological suppression may adversely effect the foetus or induce maternal hypothermia, and although physical remedies such as direct heat application are effective, they are also expensive and cumbersome. We recently found that the space blanket, a simple aluminised metallic foil, used pre-emptively, reduces shivering after general anaesthesia. We investigated the effect of the space blanket on the incidence and intensity of shivering, axilliary skin temperature, and subjective perception of cold during epidural analgesia for labour in 50 women over a four-hour time frame. Patients were randomised into group 1, who were wrapped in a space blanket immediately after commencement of epidural analgesia with bupivacaine, and group 2 (matched controls). Shivering was defined as visible tremor of the head, neck, trunk or limbs as observed by the attending midwives. Twenty-nine percent of group 1 and 35% of group 2 shivered (not significant), but a reduction in shivering intensity was observed in group 1 (P < 0.05). There was no significant difference in skin temperatures in either group, and no significant temperature change within the groups. Both groups had similar thermal comfort scores throughout the study, which correlated poorly with the presence of shivering. We conclude that there is no benefit in application of the space blanket to reduce epidural-analgesia related shivering in labour, which may indicate a non-thermogenic mechanism for this phenomenon.
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PMID:The space blanket and shivering during extradural analgesia in labour. 872 78


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