Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0040822 (tremor)
 18,428 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The clinical significance of horizontal head-shaking nystagmus (HSN) was evaluated in 85 patients who complained of dizziness and vertigo. This was done by comparison of the horizontal head-shaking test with routine rotatory and caloric vestibular testing. We found that HSN evoked by horizontal head-shaking is a highly sensitive way to detect unilateral vestibular hypofunction. Except in patients with additional central vestibular imbalance or in patients with Meniere's disease, the direction of horizontal HSN is highly significant in indicating the side of the lesion, with the fast phase beating toward the intact side. However, horizontal HSN is not specific in distinguishing peripheral hypofunction from more central vestibular imbalances. Peripheral vestibular hypofunction as well as a central asymmetry of the vestibular velocity storage mechanism can each separately or in combination produce horizontal HSN. Thus, while the head-shaking manoeuvre is an excellent bedside-test to detect unilateral vestibular hypofunction, further rotatory and caloric testing is still necessary to clarify the patient's condition.
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PMID:The clinical significance of head-shaking nystagmus in the dizzy patient. 230 63

Early in the monitoring of amiodarone it was evident that neurological events were unexpectedly frequent. A survey was then undertaken to measure the frequency of such events and to gain some impression of their clinical importance. The method of survey was the completion of questionnaires by doctors when patients were being reviewed. There was a 63.6% response rate and questionnaires were evaluated for 408 patients. There were 192 events assessed as being adverse reactions from a group of nine types of neurological events in 112 patients. Paraesthesiae, ataxia, vertigo and tremor were the most common (7-9%). The overall rate of neurological reactions was 27.5%. The individual reactions are examined as are dose relationships.
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PMID:Survey of neurological problems with amiodarone in the New Zealand Intensive Medicines Monitoring Programme. 231 44

Acute low-tone sensorineural hearing loss (ALHL) has the following three criteria; obscure origin, acute onset and sensorineural hearing loss limited to low frequencies. Sixteen cases of ALHL which were considered as cochlear hydrops using glycerol test and electrocochleogram were studied. All patients visited our department within two weeks after onset and were followed up for one year or more after initial examination. The subjective symptoms, the character of vestibular and hearing impairment and prognosis of 16 cases with ALHL were also investigated. The results were as follows. 1. Patients complained of ear fullness rather than hearing impairment. Four patients were unaware of hearing loss. 2. Recruitment phenomenon was found in all of 15 cases examined. Vestibular findings were mostly normal, except that spontaneous nystagmus was found in two cases and head-shaking nystagmus in one. 3. Recurrence and fluctuation of hearing impairment occurred in 14 cases. Three cases had an attack of rotatory vertigo once and two has diagnosed as Meniere's disease later. 4. During three months prior to last examination, hearing was stabilized in nine cases and continued to fluctuate in seven cases. In the former, hearing was improved in four cases, unchanged in three, and worsened in two. 5. Two patients underwent an endolymphatic sac operation and have had a good prognosis. 6. The authors suggest that most of ALHL should be considered as transient cochlear hydrops because the subjective symptom and audiological and vestibular findings of our cases are similar to those of cases which were reported as ALHL by other investigators. According to the findings of glycerol test and electrocochleogram, endolymphatic hydrops in ALHL is considered to exist in all turns of cochlea.
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PMID:[Clinical observations of acute low-tone sensorineural hearing loss considered as cochlear hydrops]. 234 81

The authors tested in an open, uncontrolled trial in a group of 23 patients with essential hypertension grade I-II (WHO classification) the effect of Metoprolol OROS. The OROS system is a new form of Metoprolol administration which makes it possible to maintain by a single dose per day a steady plasma concentration, while preserving the cardioselectivity and total 24-hour effectiveness during treatment of hypertension and angina pectoris. After eight weeks of Metoprolol OROS administration, in doses gradually adjusted to the therapeutic action, gradually a significant decrease of the heart rate (HR) occurred, of the systolic blood pressure (BPs) and diastolic blood pressure (BPd) (p less than 0.01 for all values) in a recumbent as well as upright position. A reduction of the BPd in an upright position by greater than or equal to 10 mm Hg was achieved in 85% of the patients, in 73.9% of the patients the BPd in an upright position dropped below 95 mm Hg. Four patients developed side-effects which were mild to medium severe (vertigo, palpitations, fatigue, sensation of tremor, tension in the lower extremities). Two patients discontinued treatment early, the main reason in both being palpitations which were under better conversely, in two patients palpitations which were not adequately controlled by previous metoprolol treatment, disappeared completely during Metoprolol OROS treatment. During the trial no significant changes in the investigated laboratory values incl. total cholesterol were recorded, Metoprolol OROS administered once per day is an effective, safe and well tolerated preparation in treatment of mild to medium severe essential hypertension.
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PMID:[The effect of OROS metoprolol in mild and moderately severe essential hypertension]. 239 74

Both miners exposed to high temperature and excess heat and miners working under permissible temperature conditions (a control group) had similar nonspecific signs, i. e., complaints of heartache and headache, erethism, flaccidity, hydrosis, degradation of appetite and sleep, vertigo, dimness, the sense of air shortage, palpitation in rest, uncertain gait, muscle spasm. There were also presented the following objective data: tremor of close eyelids, asymmetry of tendon reflex, convergence weakness, emotional lability, changes in orthostatic test results, higher Kerdau index, instability of sensitizing Romberg's test. The above signs were more pronounced in miners exposed to high temperature, thus it was possible to regard them as indicators of miners' chronic overheating.
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PMID:[Signs of chronic overheating in miners of deep coal mines]. 276 95

A scale to evaluate the withdrawal syndrome induced by tranquilizers (TWS) is proposed to distinguish between anxiety induced symptoms and withdrawal induced symptoms. This scale was established and validated by Lader, the french translation was performed by the author. The most frequently observed symptoms during a withdrawal syndrome are physical tiredness, headache, vertigo and tremor but other symptoms are evaluated by this tranquilizers withdrawal scale.
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PMID:[A scale for evaluating withdrawal symptoms induced by anxiolytic agents]. 290 55

With the increasing application of technology in medicine, clinical vestibular examination using Frenzel's spectacles is often thought to be out of date, and an electronystagmogram (ENG) is ordered. However, some important facets of the clinical behaviour cannot be determined by ENG alone, especially nystagmus after head-shaking, and the rotatory nystagmus of paroxysmal positional vertigo. Thus, in most cases routine vestibular examination is sufficient, and ENG is only indicated in certain cases. The ENG is then of considerable advantage for determining qualitative characteristics and for quantitative analysis of the nystagmus. The various methods of stimulation and of recording, the limitations and the advantages of the ENG are described in detail. An examiner fully familiar with the advantages and disadvantages of the various methods will profit from the use of ENG. However, the classical examination, including a thorough vertigo analysis, remains indispensable.
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PMID:[Indications for electronystagmography. When should the ENT physician indicate electronystagmography?]. 306 14

In 1549, Jason Pratensis published De Cerebri Morbis...(DCM), the first separate book on the general subject of neurologic disease. The publication of DCM reflected two trends in 16th century medicine: (1) interest in the anatomy and function of specific organs, and (2) retranslation of the works of Galen, who emphasized the primacy of the brain in behavioral and motor functions. Brain diseases in DCM were classified in terms of symptom complexes. Some of the 33 chapters discuss tremor, tetanus, vertigo, epilepsy, and hemicrania. Concepts of diseases, and their pathogenesis and treatment, reflected the writings of Greek, Roman, and Arabic authors, as well as newer concepts of astrology and pharmacy that were prevalent during the Renaissance. There were few new bedside or clinical observations in DCM. However, DCM is an important text, crystallizing several 16th century trends to provide the first compendium of brain disorders.
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PMID:The first neurology book. De Cerebri Morbis...(1549) by Jason Pratensis. 327 2

Epidermoid tumors located in the fourth ventricle are exceedingly rare. Seven cases of this pathological condition were observed during a 10-year period. Patients were mostly middle-aged men, with a clinical history of relatively short duration (5 months). Clinical symptoms consisted of vertigo and ataxia, followed by incoordination, dysmetria, and tremor at a later stage. Computed tomography scanning represented the main diagnostic technique for these lesions, and typically showed a highly hypodense, round-shaped area within the fourth ventricle, occasionally accompanied by hydrocephaly. Subtotal surgical removal of the cysts produced excellent results in 86% of the cases. The implications of these findings are discussed.
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PMID:Epidermoid cysts of the fourth ventricle. 334 62

Cinnarizine and flunarizine are selective calcium blockers that have been used to treat and prevent vertigo. We studied 15 patients who had extrapyramidal syndromes after taking these drugs. Eleven patients had parkinsonism, one with persistent akathisia as well; one had an orofacial tremor; one, acute akathisia alone; and one an acute dystonic reaction. All but one improved when the drug therapy was discontinued. Seven patients were also depressed during treatment. Cinnarizine and flunarizine must therefore be added to the list of potentially risky drugs known to induce extrapyramidal reactions and depression.
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PMID:Flunarizine- and cinnarizine-induced extrapyramidal reactions. 357 97


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