Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0040822 (tremor)
 18,428 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. The relationship between lithium (Li) side effects and brain Li concentration was examined in 17 patients with bipolar disorder treated with Li and other psychotropic drugs. 2. Brain Li concentration was measured by Li-7 magnetic resonance spectroscopy (MRS). Side effects were assessed using the UCLA General Side Effect Rating Scale For Lithium Treatment (GSE). 3. There was no correlation between the total GSE score and the brain, serum, or erythrocyte Li concentrations. Patients with hand tremor had significantly higher brain Li level (0.51 + or - 0.27 mM) than those without apparent tremor (0.36 + or - 0.20 mM), but no significant difference in serum Li level was seen. As far as the patients had hand tremor, they rarely had brain Li concentration less than the therapeutic range (1 of 15 measurement). On the other hand, they often had brain Li levels less than the therapeutic range when they did not have apparent tremor (13 of 52 measurements). 4. This preliminary study suggests that hand tremor is associated with the brain Li concentration.
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PMID:Lithium side effects in relation to brain lithium concentration measured by lithium-7 magnetic resonance spectroscopy. 886 Nov 79

Factors influencing the numbers of Escherichia coli DSM 682 and Staphylococcus aureus ATCC 6538 surviving exposure to disinfectants were evaluated by factorial design. Aerobic conditions during pre-cultivation rendered E. coli more resistant to the lethal activity of benzalkonium chloride (BC) and a disinfectant containing grape fruit extract (GSE), whereas Staph. aureus became more sensitive. The degree of shaking and the pre-growth medium (tryptone soy broth or Mueller-Hinton broth) did not influence the result of the bactericidal test. The number of E. coli surviving BC treatment was significantly lower if the neutralizing broth contained thiosulphate, plate pouring was used instead of plate spreading, or the plates were incubated at 37 instead of 30 degrees C. The negative effect of plate pouring was also found with Staph. aureus. The use of filtration without prior neutralization of the disinfectant decreased the numbers of chlorine-treated, but not BC-treated, E. coli. The results showed that rigorous standardization is necessary to obtain good reproducibility of bactericidal suspension tests.
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PMID:Factors influencing a suspension test method for antimicrobial activity of disinfectants. 987 21