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Query: UMLS:C0040822 (tremor)
 18,428 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a double-blind crossover trial of two 2-week treatment periods, to which 18 patients with benign essential tremor were admitted, there was no statistically significant different between progabide 11.4-20.2 mg/kg X day (median 14.2 mg/kg X day) and placebo in tremor score and tremor amplitude. However, there was a definite placebo and period effect with reduction of tremor score and tremor amplitude during the second period of treatment compared to the first period of treatment, regardless of the treatment regime. This was presumably a result of prolonged treatment and habituation to the test situation and not an effect of the active drug. No side-effects were registered and no laboratory abnormalities were seen.
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PMID:The effect of the GABA-agonist, progabide, on benign essential tremor. A controlled clinical trial. 636 17

Primidone has been reported to be effective in reducing tremor in patients with benign essential tremor. There is at least one report that suggests that the medication may reduce voice tremor, a frequent component of the essential tremor syndrome. Three patients with spastic dysphonia of essential (voice) tremor and one with more typical essential (voice) tremor were treated with primidone and experienced no alleviation in the voice signs. The side effects experienced by all patients were consistent with those noted in previous reports. Primidone does not seem to be effective in treating essential voice tremor or spastic dysphonia of essential voice tremor.
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PMID:Spastic dysphonia and essential (voice) tremor treated with primidone. 672 82

Tics are the most common movement disorder of childhood. The single tic, or habit spasm, is benign and self-limited. Complex tic disorders include other features such a multiple tics, vocal tics, and complex stereotyped movements. Tourette syndrome represents the most-severe end of a spectrum of tic disorders. The basic features are multiple tics and vocalizations with a changing repertoire over time. Severity waxes and wanes spontaneously. Treatment with haloperidol is effective but associated with a high incidence of side effects. Some cases undergo remission in late adolescence. There is a strong genetic component. Sympathomimetic drugs may precipitate the syndrome. Tremors are less common in children. Essential tremor is a benign but troublesome condition which frequently is familial. Treatment with propranolol is effective. The majority of tremors in the pediatric age group are due to underlying metabolic, endocrine, or heredodegenerative disorders. Treatment is that of the underlying biochemical abnormality.
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PMID:Tics and tremors. 694 32

Essential tremor, including the juvenile and senile variations, may be a result of a disorder of the servomechanism that controls physiologic tremor. Hands and arms are affected most commonly, and the tremor can vary in amplitude as well as frequency. Long-term treatment with propranolol has been helpful for some patients, although older patients are less likely to benefit. Other drugs and behaviour modification therapy have been less successful. Surgical treatment is effective but should probably be reserved for severe cases. An effective instrument for measuring the subjective and objective aspects of the tremor is still needed, as is an effective long-term method of treatment.
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PMID:Essential tremor. 701 58

Essential tremor is a progressive, potentially debilitating disorder that may be manifested in the voice only. In the case we report, the signs occurred concurrently with the voice characteristics of vocal cord nodules but were subtle. The mildness of the voice tremor precluded treatment at this time, although the results of medical management for the disorder have not been impressive. It is probable that some patients with severe essential (voice) tremor have undergone recurrent laryngeal nerve resection for the disorder.
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PMID:A case of vocal cord nodules masking essential (voice) tremor. 705 50

Benign essential tremor can be distinguished from parkinsonism by its rapid frequency, the involvement of voice and head, and the common finding of a positive family history. Essential tremor is less incapacitating than parkinsonism and less inexorably progressive. Propranolol (Inderal) is the best therapy available at this time. The transient beneficial effect of alcohol is deceptive. Patients with this disorder, although they find the tremor embarrassing, are generally not incapacitated and are otherwise in excellent health.
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PMID:Benign essential tremor: features that aid in diagnosis. 705 70

Essential tremor (ET) has been described in association with major dyskinesias, such as dystonia musculorum deformans, torticollis, and dystonic writer's cramp. In a series of 104 patients affected by ET, the incidence of buccolinguofacial dyskinesias (BLFD) has been investigated, including a comparison with another dyskinesia involving the facial muscles--mimic muscle tremor. The association of ET and BLFD may be casual; however, on the other hand, it might suggest the existence of a subgroup of patients suffering from a non-specific sign of motor control impairment, such as ET, in which other non-specific disorders of voluntary movement, such as BLFD, can gradually develop, particularly late in life.
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PMID:Essential tremor and buccolinguofacial dyskinesias. 716 71

Progressive difficulty in handwriting due to jerking movements precipitated by the act of writing beginning between the ages of 8 to 54 is reported in six patients. There was no rest tremor, but three had mild postural tremor. Specific muscle activity (especially pronation of the wrist or abduction of the fingers) elicited the tremors that persisted as long as the evocative posture or muscle activity was maintained. None had a family history of tremors, but two had a history suggestive of hypoxia at birth. Unlike benign essential tremor, the movements did not respond to propranolol HCl, but most patients were benefited both acutely and chronically by centrally active anticholinergic agents.
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PMID:Primary writing tremor: a selective action tremor. 719 47

The author summarises the various origins of hand tremor. Physiologic tremor can be demonstrated in any individual. This tremor is normally recordable at a stable frequency of 8-10 Hz, though this can be influenced by age, the amplitude can vary substantially. Physiological tremor is believed to have its origin in the mechanical properties of the extremities, and the firing properties of motoneurones. Essential tremor is an inherited autosomally dominant phenomenon, and is characterised by action and postural tremor. It is progressive with age. The use of low doses of theophylline in the treatment of essential tremor is emphasised, in view of the low incidence of side effects. A hypothesis is also presented to account for essential tremor in terms of an imbalance in the activity of excitatory and inhibitory amino acid system. Parkinsonian tremor may begin as postural or resting tremor on one side, and it is reduced by active movement of the affected extremity. The prognosis of Parkinson's disease presenting with tremor is better when presenting with hypokinesia. The increasing use of non-specific drugs in the treatment of Parkinsonism, and the use of thalamic high frequency stimulation are indicated.
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PMID:[Most frequent causes for hand tremor in clinical practice]. 747 62

Essential tremor is a common neurological disorder. This article reviews the phenomenology of essential tremor and related disorders (excluding parkinsonian and dystonic tremors), summarising current theories on their pathogenesis. The various treatment options are also discussed.
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PMID:Essential tremor and related disorders. 755 70


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