Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0040822 (tremor)
 18,428 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

By treating the Streptomyces olivaceus 142 strain simultaneously with ethyleneimine and UV radiation, the FPG mutant was isolated, which was characterized by the fact that in submerged cultures it produces a cytotoxic substance for fibroblasts and tumor cells and inhibits growth of pathogenic fungi. The mutant differs from other strains not only in having a different spectrum of antimicrobial activity, but also by taxonomic properties such as color of the aerial mycelium, liquefaction of gelatin, growth on cellulose, production of ammonia and nitrate reduction. An optimal culture medium and conditions of biosynthesis of the antibiotic in submerged cultures on the shaking machine and in 20-liter fermentation tanks were elaborated. The active substance was designated by the symbol WR 142-FPG.
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PMID:Antibiotics produced by Streptomyces olivaceus 142. I. Characterization of the FPG mutant and conditions of production of antibiotic WR 142-FPG. 1 63

Blood samples of 115 patients of both sexes admitted to the hospital with urinary tract infections were examined for bacteremia. Out of 115 patients 12 (10%) had positive blood cultures associated with significant urinary counts (greater than or equal to 10(5) organisms/ml). Although 10% of the patients showed positive blood cultures indicating bacteremia none of them had shaking chills, fever or any other clinical signs of septicaemia. None of the patients from whom blood samples were taken had yet received antimicrobial therapy. Bacterial isolates from urine and blood were identical. Microorganisms most frequently isolated were found in the following order: E. coli, Proteus species, K. pneumoniae and coagulase negative staphylococci. Neoplasms, obstruction of the urinary tract and age were found to be high risk factors.
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PMID:[Bacteremia associated with subfebril urinary tract infections (author's transl)]. 39 29

Cell detachment from and around Walker 256 tumors grown in rats is quantitated by a standardized in vitro shaking procedure. The volume of cells detached from cancers of similar size is virtually the same in tumors growing in the liver, the spleen, in intramuscular and in subcutaneous sites. In cystic tumors, greater volumes are detached from the innermost regions of the walls adjacent to necrotic material than from the outermost parts. More liver perenchymal cells are shaken free of liver adjacent to a tumor interface than from regions 0.5 and 1.0 cm distant from it. Detachment of tumor and liver cells is also enhanced by prior incubation of tissue samples with necrotic extracts. It is suggested that the necrotic regions of tumors, and products derived from them, facilitate the detachment of tumor cells and cells composing the normal tissues surrounding them, thereby potentially promoting metastasis and invasion.
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PMID:Tumor necrosis and cell detachment. 90 84

Conditions for optimal immunization of allogeneic lymphocytes against human tumor cells were studied. Maximal cell-mediated cytotoxic responses were generated usually with 2-4 X 10(4) tumor cells and 1 X 10(6) lymphocytes after a 5-day incubation. A further increase in the number of stimulating cells usually suppressed the immunization of lymphocytes. Viable untreated tumor cells were generally more immunogenic than were the mitomycin C-treated tumor cells. Lymphocytes (1 X )0(6)) sensitized in small volumes (0.5-1 ml) of medium were invariably transformed into cytotoxic effector cells, whereas the same number of lymphocytes sensitized in relatively larger volumes (4 ml) of medium had little or no cytotoxic activity. Occasional shaking of mixed culture during the sensitization provided better immunization than that in similar stationary culture. The replacement of culture fluids with fresh medium during incubation decreased the cytotoxicity level of sensitized cells.
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PMID:In vitro lymphocyte immunization to cultured human tumor cells: parameters for generation of cytotoxic lymphocytes. 100 25

In a series of 27 patients with proved pheochromocytoma, differential analysis of catecholamines in blood, urine, and tumor specimens of 19 patients enabled grouping of subjects into those whose tumors produced predominantly norepinephrine (NE) (11 patients), predominantly epinephrine (E [Two patients]) and approximately equal amounts of both (six patients). Sustained hypertension was more common in the first group and pallor and tremor in the latter two groups, but no distinctive syndrome could be recognized as signifying the secretion of NE or E. Headache was a symptom in 20 of 27 patients and was related to sudden, transient elevation of the blood pressure, rather than sustained hypertension. The variable duration and intensity of the headache in different patients can be explained by the pressor and cranial vasoconstrictor effects of the secreted amines, which respectively enhance and diminish vascular headache.
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PMID:Symptoms of pheochromocytoma, with particular reference to headache, correlated with catecholamine production. 125 42

We report on a 44-year-old woman with a right frontal meningioma, who presented with resting tremor, rigidity and bradykinesia in the left limbs. There were no other neurologic manifestations. A computed tomography scan demonstrated a huge high-density mass in the right frontal lobe and marked surrounding edema causing compression of the basal ganglia. Cerebral angiography showed a typical sunburst tumor stain and three feeding vessels from the bilateral middle meningeal arteries and the right callosomarginal artery. The pathologic diagnosis was transitional type meningioma. Before surgery, treatment with levodopa and bromocriptine was significantly effective in controlling hemiparkinsonism, which completely disappeared after surgical removal of the tumor. This outcome supports the notion that local compression due to edema may cause a functional disorder in the basal ganglia producing reversible contralateral parkinsonism.
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PMID:Hemiparkinsonism in a patient with frontal meningioma. 136 48

Toxicity and carcinogenicity studies of musk xylol were examined in B6C3F1 mice. The LD50 of the chemical was considered to be more than 4000 mg/kg. In the acute toxicity and 14-day repeated-dose oral toxicity studies, tremor was observed in some animals given high doses of the chemical. In the 17-week repeated-dose oral toxicity study, musk xylol was given at dietary dose levels of 0.0375, 0.6%. During the experimental period, almost all mice given 0.3% or more died. There was no difference in the body-weight gain between the treated groups given 0.15% or less and the control group. Histologically, enlargement and irregularity of hepatocyte were found in both sexes given 0.15% or more. Based on the results, the chemical was given at dietary levels of 0 (control), 0.075 or 0.15% for 80 weeks in the carcinogenicity study. Overall tumor incidences in all treated groups of both sexes were significantly higher than those in the respective controls. Combined malignant and benign liver cell tumors increased clearly in both sexes and a significant positive trend for the occurrence of hepatocellular carcinomas was noted in males. Incidences of lung and Harderian gland tumors and lymphomas in treated groups were also slightly higher than those in controls. In addition, incidences and total numbers of malignant tumors increased significantly in treated groups of both sexes, although no dose-relation was evident. The results demonstrated that musk xylol is carcinogenic in B6C3F1 mice of both sexes when given at dose-levels of 0.075 or 0.15% in the diet for 80 weeks.
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PMID:[Toxicity and carcinogenicity studies of musk xylol in B6C3F1 mouse]. 136 67

Muramyl tripeptide phosphatidylethanolamine (MTP-PE; CGP 19835A from Ciba Geigy) is a synthetic muramyl tripeptide structurally related to bacterial cell wall constituents. MTP-PE activates monocytes in vitro to a tumoricidal state and has in vivo antitumor effects in animal models. We studied the toxicity and immunomodulatory effects of once weekly i.v. administration of liposomal-encapsulated MTP-PE for 8 weeks in 27 patients with advanced malignancies. Doses ranged from 0.1 to 2.7 mg/m2. No major tumor responses were seen; 11 patients had stable disease after 8 weeks of therapy and 3 continued on maintenance therapy because of minor tumor regressions and/or clinical improvement. MTP-PE at these doses was well tolerated. Shaking chills and fevers were the most common toxicities and occurred at all dose levels. There was no treatment-induced loss of performance status. Immunomodulatory studies revealed evidence of a biological effect on monocytes. C-reactive protein levels rose in the majority of patients with end-of-treatment values 2 to 10 times higher than baseline. Serum neopterin levels were consistently increased 24 h after MTP-PE administration and significant decreases in expression of two different types of Fc receptors on peripheral blood monocytes were noted 6 h after treatment. Although no major tumor responses were seen in this group of patients with advanced malignancies, MTP-PE was well tolerated and exerted biological effects on monocytes. Serum neopterin levels may be a useful marker for the biological effects of MTP-PE.
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PMID:Phase I and immunomodulatory study of a muramyl peptide, muramyl tripeptide phosphatidylethanolamine. 169 52

A chart review from 151 dysphonic patients over the age of 60 was done to define aging related voice disorders. Overwhelmingly, patients suffered from dysphonia due to disease processes associated with aging rather than to physiologic aging alone. These include: 1. central neurological disorders affecting laryngeal function (e.g., stroke, Parkinson's disease, essential tremor, Alzheimer's disease); 2. benign vocal fold lesions (e.g., Reinke's edema, benign and dysplastic epithelial lesions); 3. inflammatory disorders (e.g., laryngitis sicca, medication effect); 4. laryngeal neoplasia; and 5. laryngeal paralysis. Typical laryngeal findings of vocal fold bowing and breathiness consistent with presbylarynges were present in only six patients. Presbylarynges is not a common disorder and should be a diagnosis of exclusion made only after careful medical and speech evaluation.
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PMID:Dysphonia in the aging: physiology versus disease. 173 85

We are presenting an uncommon case of cerebral tumor whose major manifestation was parkinsonism. The patient was a 50-year-old woman presented with a 5-month history of tremor of the right hand, particularly at rest, and headache. On neurological examination of March, 1987 there were: slight right-sided hemiparesis with symmetrical hyperreflexia; discrete bradykinesia in combination with cogwheel rigidity also on the right-side; resting tremor of the right hand; and bilateral papilledema. The neuropsychological examination disclosed: nominative aphasia, impaired recent memory and right-left disorientation. The computed tomography showed a large, left frontotemporal tumor. Angiograms of the left internal and external carotid arteries revealed a tumor blush in the left frontotemporal region supplied by a enlarged middle meningeal artery. An electromyogram revealed a 4-6 HZ tremor on right hand. A course of treatment with dexamethasone 16 mg/day and levodopa plus benzerazine (500 mg/day) was unsuccessful. A left fronto-temporo-parietal craniotomy was performed and an attached sphenoid wing tumor was macroscopically completely removed. Microscopy indicated that the tumor was a meningioma. Postoperatively, the patient made an uneventful recovery. After two weeks, her right-sided palsy and parkinsonism had disappeared, and neuropsychological deficits improved. Two months later there was no abnormalities on neurological and neuropsychological examination. It was concluded that the parkinsonism was caused by mechanical pressure on the basal ganglia.
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PMID:[Parkinson disease associated to a brain tumor: a case report]. 180 37


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