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This paper reports findings from a study of the knowledge and attitude toward AIDS of 738 secondary school youths in Calabar. Queried in March 1991, 10.3% of the respondents were under age 15, while 79.5% were aged 15-20. 92% had heard about AIDs, with 79-85% doing so through the mass media. The input of parents and teachers was noted in less than 40% of cases. 30% did not know AIDS existed in Nigeria. Most knew that promiscuity, blood transfusions, sharing injection needles and syringes are the major modes of transmission, yet some held that toilet seats, eating utensils, hand-shaking, and kissing are risk factors for contracting HIV. Only 31% were aware that condoms provide protection, so their use to that end was suggested by only 2.6%. Instead, 45% prefer to abstain and 19% choose to remain monogamous in order to protect themselves from HIV. To prevent the spread of AIDS, 37% recommended that cases be isolated, 34% recommended treatment, and 14% though cases should be executed. 77% and 63% responded that they would stop seeing, respectively, friends and relatives who develop AIDS. 61% were unaware that no cure exists for AIDS. In light of these findings, it is recommended that doctors in the community help disseminate accurate information with the support of parents, teachers, and youths.
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PMID:Acquired immunodeficiency syndrome: education exposure, knowledge and attitude of Nigerian adolescents in Calabar. 128 69

The shaking method of harvesting human immunodeficiency virus type 1 (HIV-1) is a powerful method of obtaining high titer, highly infective virus solutions. In this method infected cells are suspended in a small volume of liquid and the mixture is shaken. Viral infectivity, measured by tissue culture infective dose (TCID50) studies, rises faster than virus titer, as measured by reverse transcriptase levels. It is postulated that this disproportionate increase in infectivity results from improved infectivity for the virus particles obtained from shaking the infected cells. Of the five strains of HIV-1 studied (IIIB, AL1212, 906, RJ4029, and MN), one strain, MN, behaved differently than the others. Upon shaking, its virus titer increased 18-fold, as opposed to the 5-10 fold increase demonstrated by the other strains. These results may indicate that MN virions are retained more on the surface of the infected cells, rather than budding off into the surrounding medium, than other HIV-1 strains. In support of this theory it was found that ratios of immunofluorescence assay scores to reverse transcriptase levels were higher for MN than for other strains.
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PMID:Shaking HIV-1 infected cells indicates novel behavior of MN strain. 171 47

The purpose of this investigation was to study the knowledge about HIV infection and AIDS among dental students in Helsinki, Finland, and in Dar es Salaam, Tanzania. All respondents knew that HIV is not transmitted via hand-shaking, drinking water, or breathing air. More than half of the students in both countries did not know that HIV can be transmitted via breast-feeding. A higher proportion of students in Dar es Salaam than in Helsinki believed that all HIV-positive persons will get AIDS. Tanzanians recognized the early symptoms of HIV infection better than the Finnish students. Many students in both countries did not mention bisexual men as belonging to the high-risk group. Most of the dental students in Dar es Salaam but only one in five in Helsinki believed that dentists belong to the at-risk group.
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PMID:Dental students' knowledge of AIDS and HIV infection in Helsinki, Finland, and in Dar es Salaam, Tanzania. 205 32

As has been summarized above, the risk of casual contact transmission of HIV virus is remote. A review of these data should provide reassurance to both workers and management. No evidence exists for direct contact spread through shaking hands and nonsexual touching. There is also no evidence for indirect spread through contact with shared inanimate objects such as typewriters, telephones, computers, water fountains, rest rooms, dining facilities, exercise equipment, bathing facilities, spas, saunas, and swimming pools. In addition, there is no evidence to suggest the airborne spread of HIV, thus there should be no potential risk of transmission through air-conditioning units, air-handling systems, or by sharing the same office space with an infected individual. The fear of AIDS may lead to irrational beliefs and biased perceptions of risk. This, unfortunately, can sometimes lead to discriminatory and inhumane treatment of persons with AIDS. The best way to manage this potential problem in the workplace is through effective educational interventions.
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PMID:HIV infection risk to nonhealth-care workers. 227 Aug 27

Motor tests were performed in 50 HIV-infected patients in all stages according to the current CDC classification, but without any clinically evident central nervous system deficit, and the results compared with an age-matched control group. Patients were excluded from the study if there was alcohol or drug abuse, fever and/or opportunistic cerebral infection. The parameters tested were postural tremor of the outstretched hands, most rapid voluntary alternating index finger movements (MRAM) and rise time of most rapid index finger extensions (MRC). Whereas tremor peak frequencies did not differ significantly in the patients and controls, MRAM and rise times of MRCs showed significant slowing in the patient group. Morphologically, the motor test performance of the HIV-infected patients was similar to that of patients with manifest basal ganglia disease (Parkinson's, Huntington's and Wilson's diseases). MRI scans of all patients were normal. It is concluded that in HIV-infected patients there is a very early subclinical central nervous system affection, especially of the basal ganglia, which is detectable with appropriate, quantitative motor function tests. These functional abnormalities precede the structural alterations in the MRI scans.
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PMID:Motor dysfunction in HIV-infected patients without clinically detectable central-nervous deficit. 227 70

This study presents the main clinical findings on 200 AIDS patients at Kilimanjaro Christian Medical Centre in the northern zone of Tanzania, with detailed neurological findings on 135 out of 200 cases and 53 controls. Results show that 21 out of 200 (10.5%) had an obvious focal neurological disorder, including cranial nerve palsies, hemiparesis and paraparesis. Ninety-seven out of 135 (72%) had less obviously detectable neurological disorders, versus 36% of controls (P less than 0.005). Most frequent were AIDS dementia complex (54%), retinopathy (23%), areflexia (21%), pyramidal tract signs (19%) and tremor and incoordination (19%). Frontal lobe release signs (FLRS) were found in 103 out of 135 (76%) patients, versus 36% of controls (P less than 0.005). Advanced and terminal AIDS cases were more likely to have neurological disorders than early AIDS patients. A further study on 87 non-AIDS patients with acute unexplained neurological disorders showed 10 out of 87 to be HIV seropositive. Three case studies are presented. This study suggests that neurological disorders are among the main clinical features of AIDS and HIV disease in Africa.
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PMID:Neurological disorders in AIDS and HIV disease in the northern zone of Tanzania. 250 33

Motor (postural tremor of the outstretched hands, most rapid voluntary alternating index finger movements and rise times of most rapid voluntary isometric index finger extensions) and psychometric tests (multiple choice vocabulary test - form b, syndrome short test, the German version of the standard progressive matrices - Raven, and the psychic and somatic findings according to the AMDP-system) as well as MRI-Scans were analysed in 100 HIV-infected patients of all stages according to the actual CDC-classification, but without any central-nervous or psychic deficit. Patients with drug, alcohol or tranquilizer abuse, opportunistic, cerebral infections or fever were excluded from the study. Tremor-peak-frequencies and reaction times did not show any significant difference to an age- and sex-matched control group; the other motor parameters revealed significant slowing in the patient group and a worsening with the CDC-stages. MRI-scans of all the patients were normal. The psychometric tests did not show significant alterations on a group statistical level, especially not in the depression scales. Morphologically, the motor performances of the HIV-infected patients resembled those of patients with basal ganglia diseases (M. Huntington, M. Wilson, M. Parkinson). Correspondingly, in some cases of clinically demented HIV-positive patients, MRI-scans showed lesions in the basal ganglia. It can be concluded, that there is an early subclinical central-nervous system affection in HIV-infected patients, especially of the basal ganglia, detectable with appropriate motor function tests sometimes considerably preceeding structural deficits seen later in the course of the disease in MRI-scans.
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PMID:[New electrophysiological findings on the incidence of brain involvement in clinically and neurologically asymptomatic HIV infections]. 251 87

Motor tests comprising the analysis of postural tremor, most rapid voluntary alternating index finger movements (MRAM) and the rise time of most rapid index finger extensions (CT) allow us to quantify HIV-associated minor motor deficits electrophysiologically. The electrophysiological results in 57 HIV-positive individuals who acquired HIV infection by intravenous drug abuse (IVDA) were compared with those of 57 matched HIV-positive homosexuals and 98 HIV-negative controls to evaluate a possible additional influence of IVDA on motor performance. Motor deficits showed no differences between HIV-positive i.v. drug abusers and homosexuals, revealing a highly significant slowing of MRAM and prolongation of CT to an almost identical extent. Thus, in HIV-infected individuals minor motor deficits are characteristic early signs of subclinical central nervous system involvement regardless of the mode of HIV infection.
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PMID:HIV-specific changes in the motor performance of HIV-positive intravenous drug abusers. 789 48

Investigations were carried out in 1991 in 218 persons in Lublin county who were divided into 2 groups: Group I comprised 118 persons 18-25 years old, who had completed primary school, basic level trade school, or secondary school, and Group II consisted of 100 persons 40-60 years old, who had completed primary, secondary, or higher level schooling. A questionnaire asked about the probability of HIV infection in Poland, the routes and time of transmission, prevention methods, and knowledge about AIDS. Responses to the questions concerning the route of transmission were similar in both groups: sexual intercourse, use of narcotics, needle prick conveying blood of infected person, blood transfusion, maternal-fetal exchange, childbirth, and breast-feeding. Group II more frequently indicated the possibility of infection through sharing food, kisses, working together, riding the bus, and shaking hands with an infected person. Transmission of HIV by insects was asserted by 26.3% of Group I and 38% of Group II. Regarding transmission from persons with negative test results, 7.6% of respondents in Group I and 9.0% in Group II stated that it was possible to get infected from them, while 59.3% and 79.0%, respectively said it was not. As to prevention of HIV infection, 76.2% in Group I and 42% in Group II advocated the use of condoms, 59.3% and 44%, respectively, stated the need for a steady partner and avoidance a casual partners, 33.1% and 24.0%, respectively, mentioned single uses of medical instruments, but only 3.4% and 0%, respectively, referred to avoiding contact with blood. Familiarity with the topic of AIDS before filling out the questionnaires was reported by 61.9% in Group I and 59.0% in Group II. Basic sources of knowledge were derived from television, radio, press, specialist brochures, lectures, and acquaintances. The topic of AIDS was of interest to 83.1% in Group I and 71.0% in Group II. Regarding acceptance of an HIV-infected person in their vicinity, 40.7% in Group I said yes vs. 30.0% in Group II; while 44.1% and 63.0%, respectively, said no.
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PMID:[Awareness of AIDS in selected population groups from the province of Lublin]. 823 44

The objectives were to describe the sexual practices of high school students; to describe the process of development of a school-based AIDS prevention program; and to evaluate the effect of this program on students' AIDS-related knowledge, attitudes and AIDS-preventive behaviors by means of self-administered questionnaires. A cluster-randomized, controlled trial with pretest/post-test evaluation was conducted in 4 demographically similar public high schools in a semi-urban district of Metro Manila, the Philippines. Of 845 high school students who participated in the baseline survey, 804 (95%) completed a postintervention questionnaire. An AIDS prevention program was developed by public high school teachers together with local AIDS experts, social scientists, and health educators to provide students with accurate information about AIDS, dispel misconceptions about casual contagion, to foster positive attitudes towards people with AIDS, and to develop skills aimed at assessing intended behavior. At baseline, 80 (11%) of 804 students reported ever having had sexual intercourse (mean age 14 years). 66 were male and 14 were female (p 0.001). Among these, condom use was low (24%). Reasons for failure to use condoms were: use of other method (26%) and loss of sensitivity (25%). After implementation of the AIDS prevention program, the intervention group was more likely to answer correctly that HIV cannot be transmitted by mosquito bites (p 0.01), through a cough or sneeze (p 0.01), or by shaking hands with an infected person (p 0.01). Students who had attended the AIDS education program were less likely to avoid people with AIDS and were more compassionate toward them (p = 0.01). Changes in knowledge about modes of HIV transmission were associated with improvements in preventive knowledge (p 0.001). While there was no statistically significant overall effect on intended preventive behavior, the program appeared to delay the students' intended onset of sexual activity. The program was successful in increasing AIDS-related knowledge and improving attitudes toward people with AIDS.
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PMID:Results of a model AIDS prevention program for high school students in the Philippines. 856 4


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