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Query: UMLS:C0040822 (tremor)
 18,428 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of status epilepticus with transient motor deficit is reported in a 66 year old male treated with fluvoxamine. Fluvoxamine is supposed to induce few epileptic seizures. The patient had no previous history of epilepsy. Two factors seem to have favoured the occurrence of epilepsy: presence of an incipient arteriopathic impairment, cortical and subcortical brain atrophy and perhaps drug overdosage causing a tremor in the days before the epileptic fit.
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PMID:[Epileptogenic action of fluvoxamine. Apropos of a case]. 311 16

Families were identified, in north-east Wiltshire (UK), (population 200,000), in which there was a pattern of two or more generations of child maltreatment and where there were also two or more children maltreated in the current generation (born between 1960 and 1980). These children had high rates of mental handicap, backwardness, and antisocial behaviour, and there were also characteristic patterns of emotional disturbance. The post-neonatal death rate for the 294 index children was very high, but higher still for their brothers and sisters. Some of the deaths, and at least 11 cases of violence-induced mental handicap (VIMH), were caused by characteristic types of child abuse - particularly violent shaking and throwing of infants, and secret suffocatory practices. There were very strong indications that larger numbers of children than the 11 proven VIMH cases had also suffered blunting of the intellect, physical complications such as epilepsy, and educational problems, as well as emotional and social maladjustment as the consequence of ill-treatment and neglect. Within the families, for children remaining at home, forms of ill-treatment and poor quality care persisted and ultimately affected most, or all, of the children in each family unit. Many families were chaotic, and within each family unit there were children frequently in care who suffered multiple placements, and who needed sustained specialist support throughout their childhood, encompassing a huge range of professional and other social support services. Such detail was generally underplayed or not accessible, and its full significance for children in each family could only be assessed by combining direct personal clinical involvement with record linkage methods, depending in turn on good co-operation from all agencies concerned wholly or partly with child protection.
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PMID:Successive generations of child maltreatment. The children. 325 Jun 97

In 1549, Jason Pratensis published De Cerebri Morbis...(DCM), the first separate book on the general subject of neurologic disease. The publication of DCM reflected two trends in 16th century medicine: (1) interest in the anatomy and function of specific organs, and (2) retranslation of the works of Galen, who emphasized the primacy of the brain in behavioral and motor functions. Brain diseases in DCM were classified in terms of symptom complexes. Some of the 33 chapters discuss tremor, tetanus, vertigo, epilepsy, and hemicrania. Concepts of diseases, and their pathogenesis and treatment, reflected the writings of Greek, Roman, and Arabic authors, as well as newer concepts of astrology and pharmacy that were prevalent during the Renaissance. There were few new bedside or clinical observations in DCM. However, DCM is an important text, crystallizing several 16th century trends to provide the first compendium of brain disorders.
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PMID:The first neurology book. De Cerebri Morbis...(1549) by Jason Pratensis. 327 2

There is a paucity of trained neurologists in developing countries. We designed a questionnaire to rapidly screen a community of 851 people (Parsis living in a colony in Bombay, India) for possible neurologic diseases. This questionnaire was pretested and found to have a sensitivity of 100 percent for detecting epilepsy, febrile seizures (only in children), completed stroke, peripheral neuropathy, movement disorders, cerebral palsy, mental retardation, and severe dementia. The screening questionnaire was administered by trained lay health workers. One hundred and sixty-three people were identified by this questionnaire as possibly having neurologic disease. Neurologists later examined these 163 people and found that 80 of them actually suffered from at least one of the neurologic diseases of interest (positive predictive value = 48 percent). The most common neurologic disorders were peripheral neuropathy (32 cases), essential tremor (13 cases), stroke (12 cases), Parkinson's disease (six cases), and epilepsy (four cases).
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PMID:Pilot survey of the prevalence of neurologic disorders in the Parsi community of Bombay. 333 Jun 62

Behavioral, electroencephalographic and morphological changes induced by systemic administration of pilocarpine hydrochloride were studied in 3-90-day-old rats. Pilocarpine, 100, 200 and 380 mg/kg, presented a characteristic array of behavioral patterns in developing rats. Hyper- or hypoactivity, tremor, loss of postural control, scratching, head bobbing and myoclonic movements of the limbs dominated the behavior in 3-9-day-old rats. No overt motor seizures were observed in this age group. More intense behavioral signs evolving in some animals to limbic seizures and status epilepticus occurred when pilocarpine was administered in 12-day-old-rats. The electrographic activity in these animals progressed from low voltage spiking registered concurrently in the hippocampus and cortex during the first week of life into localized epileptic activity in the hippocampus, which spread to cortical recordings during the second week of life. No morphological alterations were detected in the brains of 3-12-day-old rats subjected to the action of pilocarpine, 100-380 mg/kg. The adult pattern of behavioral and electroencephalographic sequelae after pilocarpine was encountered in 15-21-day-old rats. Akinesia, tremor and head bobbing progressed in 15-21-day-old rats given pilocarpine, 100-380 mg/kg, to motor limbic seizures and status epilepticus. The lethal toxicity of pilocarpine reached 50% during the third week of life. This increased susceptibility to the convulsant action of pilocarpine was characterized by a shortened latency for behavioral and electrographic signs, and an increased severity of seizures relative to older and younger rats. In 15-21-day-old rats subjected to pilocarpine-induced convulsions high voltage fast activity superposed over hippocampal theta-rhythm, progressed into high voltage spiking and spread to cortical records. The electrographic activity became well synchronized and then developed into seizures and status epilepticus. Morphological analysis of frontal forebrain sections in 15-21-day-old rats which underwent status epilepticus after pilocarpine revealed no damage or an attenuated pattern of damage. In 15-21-day-old rats which presented epilepsy-related brain damage, morphological breakdown was seen in the hippocampus, amygdala, olfactory cortex, neocortex and certain thalamic nuclei. No damage was detected in the substantia nigra and lateral thalamic nucleus. An adult pattern of the damage to the brain, in terms of extent and topography, was present in 4-5-week-old rats.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:The susceptibility of rats to pilocarpine-induced seizures is age-dependent. 344 Feb 12

In the rat, zitter (zi) and tremor (tm) are autosomal recessive mutations that in homozygotes caused curled whisker hair, and tremor when the animals move. In both mutant types, the presence of many vacuoles gives the central nervous system a spongy appearance. The mutants differ sharply in one important characteristic: zitter rats are fertile, tremor rats are sterile. The F1 hybrids between zitter homozygous females and a tremor heterozygous male were all normal, and data from subsequent crosses revealed that zi and tm are neither allelic nor linked to each other. In animals homozygous for both mutations, an epileptic seizure frequently and spontaneously occurred from 7 or 8 weeks of age. Although the epileptic seizure has not been studied in detail, it may be an excellent animal model of epilepsy.
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PMID:Epileptic seizures in rats homozygous for two mutations, zitter and tremor. 355 68

A single case of one-to-one correspondence between eyelid flutter and EEG alpha rhythm is reported. It arose during a battery of experiments into possible personality correlates of eyelid conditioning, EEG evoked potential and skin potential habituation, involving over 400 subjects. The reported phenomenon lasted for one burst of 24 sec. and another of 6 sec. during 40 min. of recording on one subject. The observation is considered in the light of reported cases of links between EEG alpha and epileptic seizure and also between EEG alpha, Parkinsonism, and finger tremor. A time-keeping role for EEG alpha in the brain is postulated.
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PMID:EEG alpha rhythm and eyelid flutter. 360 93

A systematic study of the epileptic electrocerebral and behavioural effects of intraperitoneal kainic acid (KA) was carried out in 92 adult albino Wistar rats. The doses of KA ranged from 3 to 20 mg/kg. Chronic epidural and stereotaxically implanted cerebral electrodes (hippocampus, amygdala and thalamic reuniens nucleus) were used. All animals were studied for 5-12 after KA injection; in 20 animals the study was extended to 10 days. Sporadic spiking was the early EEG manifestation of epilepsy. Subsequently, ictal discharges were recorded. Both types of epileptic discharges were at first focal and then generalized. In the majority of animals, both types of electrographic events were first recorded from the limbic structures; in 7 to 35% of cases, however (depending on the dose of KA), they first appeared in the neocortex. Two groups of behavioural manifestations were observed: searching, staring spells, wet-dog shaking and gnawing: these could be independent of any recorded EEG epileptic event; and rearing, head nodding, forelimb clonus and tonic-clonic spells: these were always related to EEG epileptic activity, mostly generalized discharges. Spiking was still recorded from various structures 10 days after the KA injection.
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PMID:Electrocerebral and behavioural analysis of systemic kainic acid-induced epilepsy in the rat. 375 63

To determine the prevalence of frequently occurring neurologic disorders in a biracial population, a survey of households and chronic care institutions was carried out for all residents of Copiah County, Mississippi. Along with a complete census, interviews were held using extensive questions about diagnoses, signs, and symptoms of neurologic disorders. More than 97% of eligible households participated, comprising 23,842 persons (49% black, 50% white, 1% other). Persons with responses suggesting one or more of these disorders were examined by a neurologist who used defined diagnostic criteria. Age-adjusted prevalence ratios for cerebral palsy, epilepsy, stroke, and severe dementia were somewhat higher in blacks than in whites, while the age-adjusted prevalence ratio for essential tremor was slightly higher in whites. For Parkinson's disease, there was no difference in age-adjusted prevalence ratios between the races.
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PMID:Survey of major neurologic disorders in a biracial United States population: the Copiah County Study. 382 20

A patient is described who developed unilateral seizures whilst being treated with recombinant interferon for hairy cell leukemia. Special features included the relatively low dose of interferon, the focal aspect of the epilepsy and the high resistance to anticonvulsants. Oligoclonal banding of cerebrospinal fluid proteins may have resulted from polyclonal activation of bone marrow plasma cells during interferon treatment. Disturbances of consciousness, dysphasia, visual hallucinations, upper motor neuron deficit, tremor, dizziness, numbness, myalgia and headache, all of them neurological complications of interferon treatment, are discussed.
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PMID:Unilateral seizures in a patient with hairy cell leukemia treated with interferon. 393 49


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