Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0040822 (tremor)
 18,428 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One of the case of the angiographically disappeared giant aneurysm is reported, which was arising from the top of the basilar artery. A 52-year-old man was admitted in April, 1978. He had developed a recent memory disturbance, tremor in the both upper extremities, the rigidity of the four extremities, an ataxic gait and urinary incontinence. Enhanced CT scan on admission demonstrated a large oval mass in the suprasellar region indenting nearly total third ventricle. Bilateral lateral ventricles were significantly dilated. The initial vertebral angiogram shortly after the admission revealed an oval-shaped aneurysm, 27 mm in the longest diameter, arising from the top of the basilar artery. The aneurysm was considered to be inaccessible due to its anatomical location and size. A ventriculoperitoneal shunt was placed, which alleviated clinical symptoms and signs immediately. However, a vertebral angiogram 1 year following the initial angiogram showed significant enlargement of the aneurysm, in spite of hypotensive and coagulant drugs which had been administered, then the administration of hypotensive drugs was ceased. Ventriculo-peritoneal shunt was replaced by ventriculo-atrial shunt in Sep. 1980. Left vertebral angiogram in May, 1981, 3 years after the initial angiogram, demonstrated the aneurysm had completely disappeared. He has been followed-up by the repetitive angiography up to the present, which proved the aneurysm has not reappeared. The occurrence of a spontaneous angiographical disappearance of an intracranial aneurysm is relatively uncommon, especially of a giant aneurysm. A rare case of spontaneous angiographical disappearance of a giant aneurysm was presented in this report.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Spontaneous angiographical disappearance of an unruptured giant aneurysm of the basilar top demonstrated by a sequential series of angiograms. A case report]. 408 84

The "Shaken Baby" syndrome (SBS) is the subject of intense controversy; the diagnosis has in the past depended on the triad of subdural haemorrhage (SDH), retinal haemorrhage and encephalopathy. While there is no doubt that infants do suffer abusive injury at the hands of their carers and that impact can cause catastrophic intracranial damage, research has repeatedly undermined the hypothesis that shaking per se can cause this triad. The term non-accidental head injury has therefore been widely adopted. This review will focus on the pathology and mechanisms of the three physiologically associated findings which constitute the "triad" and are seen in infants suffering from a wide range of non-traumatic as well as traumatic conditions. "Sub" dural bleeding in fact originates within the deep layers of the dura. The potential sources of SDH include: the bridging veins, small vessels within the dura itself, a granulating haemorrhagic membrane and ruptured intracranial aneurysm. Most neuropathologists do not routinely examine eyes, but the significance of this second arm of the triad in the diagnosis of Shaken Baby syndrome is such that it merits consideration in the context of this review. While retinal haemorrhage can be seen clinically, dural and subarachnoid optic nerve sheath haemorrhage is usually seen exclusively by the pathologist and only rarely described by the neuroradiologist. The term encephalopathy is used loosely in the context of SBS. It may encompass anything from vomiting, irritability, feeding difficulties or floppiness to seizures, apnoea and fulminant brain swelling. The spectrum of brain pathology associated with retinal and subdural bleeding from a variety of causes is described. The most important cerebral pathology is swelling and hypoxic-ischaemic injury. Mechanical shearing injury is rare and contusions, the hallmark of adult traumatic brain damage, are vanishingly rare in infants under 1 year of age. Clefts and haemorrhages in the immediate subcortical white matter have been assumed to be due to trauma but factors specific to this age group offer other explanations. Finally, examples of the most common causes of the triad encountered in clinical diagnostic and forensic practice are briefly annotated.
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PMID:The "Shaken Baby" syndrome: pathology and mechanisms. 2194 57