Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0040822 (tremor)
 18,428 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Iron plays a crucial role in the survival, differentiation, and myelin formation of oligodendrocyte lineages. However, the regulation mechanism of iron homeostasis in oligodendrocytes remains unclear. Recently, much research has focused on Ferroportin 1 (FPN1), an iron exporter protein. First, about 95% pure primary rat O-2A progenitor cells were obtained by shaking methods in our laboratory. The expression of FPN1 mRNA and protein in O-2A progenitor cells were determined by reverse transcription-PCR and western blot. In addition, the localization of FPN1 at the cell membrane, in the cytoplasm and in processes was assayed by double-labeling immunofluorescence. A time-dependent increase of iron efflux from O-2A progenitor cells was confirmed by the calcein-indicated iron efflux assay. However, the same cells treated with FPN1 antibody showed no obvious change in iron release. For further confirmation, overexpression of FPN1 in O-2A progenitor cells was transduced with lentivirus. The release of iron in O-2A progenitor cells was dramatically increased by the overexpressed FPN1 when compared with that of the control group. Both ferritin (Ft) and transferrin receptor (TfR) are routinely used as indicators of labile iron pool. Cells pretreated with FPN1 antibody upregulated Ft and downregulated TfR protein level, while the opposite results occurred in the FPN1 overexpressing cells. Determination of Ft and TfR indirectly indicated that FPN1 might contribute to iron release from O-2A progenitor cells. We suggested that expression of FPN1 in O-2A progenitor cells might play a critical role in iron efflux from these cells.
Anat Rec (Hoboken) 2013 Jan
PMID:Expression and function of ferroportin 1 in O-2A progenitor cells. 2311 87

Plastic spectacles are often fitted to pheasants in laying pens to reduce feather pecking and egg eating. This study examined the effects of spectacles on the physiological condition and behaviour of pheasants in harem and flock laying pens. In 2006 and 2007, data were collected from 21 game farms across England. On each site, two identical pens were randomly allocated a treatment, with or without spectacles. The physiological condition of pheasants in each treatment pen was assessed before and after the laying season. In flock pens, the behaviour of spectacled and non-spectacled pheasants was also assessed weekly. Detailed records of egg collections and mortality were also kept. Spectacles had no effect on the behaviour of male pheasants but affected the behaviour of females by reducing pecking and increasing head shaking/scratching. Although spectacles halved feather damage in females, and at least halved incidences of skin damage in both sexes, they increased bill and nostril damage in females while causing no detectable damage in males. Egg collections and mortality rates did not differ between spectacled and non-spectacled pens.
Vet Rec 2014 Feb 22
PMID:The effects of plastic spectacles on the condition and behaviour of pheasants. 2442 Aug 72

Current and emerging issues: avian influenza and Schmallenberg virusHighlights from the scanning surveillance networkUpdate on international disease threatsCongenital tremor associated with atypical porcine pestivirus These are among matters discussed in the Animal and Plant Health Agency's (APHA's) disease surveillance report for December 2016.
Vet Rec 2017 Jan 14
PMID:Disease surveillance in England and Wales, December 2016. 2808 98

A novel spongiform leucoencephalomyelopathy was reported in border terrier puppies in 2012 causing a shaking puppy phenotype, but no information regarding clinical progression, imaging or electrophysiological findings were available. The aim of the present study was to describe the clinical, electrophysiological and MRI features of this disease in seven dogs and compare them with human white matter disorders. All cases presented with cerebellar ataxia and severe generalised coarse body tremors, which started at three weeks of age. The three cases that were not euthanased showed slow but progressive improvement over several months. Brainstem auditory evoked response demonstrated a normal wave I, reduced amplitude of wave II and an absence of waves III-VII. MRI revealed bilateral and symmetrical T2-weighted hyperintensities affecting the brainstem and cerebellar white matter. Histological examination of the brain and spinal cord showed spongiform change affecting the white matter of the cerebellum, brainstem and spinal cord with decreased myelin content. In summary, this leucoencephalomyelopathy has a pathognomonic clinical presentation with defining MRI and electrophysiological characteristics, and it is the first report to describe a long-term improvement of this condition.
Vet Rec 2019 09 28
PMID:Spongiform leucoencephalomyelopathy in border terriers: clinical, electrophysiological and imaging features. 3134 36


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