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Query: UMLS:C0040822 (tremor)
 18,428 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Some of the brains submitted for neurohistopathological examination under the Bovine Spongiform Encephalopathy (BSE) Orders did not show lesions of BSE. They showed neuronal chromatolysis and necrosis of the brainstem, perivascular cuffs and meningeal infiltrates of mononuclear cells and large irregularly shaped vacuoles in the neuropil. About half of them also showed loss of pyramidal neurons in the hippocampus, with astrocytic gliosis. The topography of the brainstem neuronal degeneration and vacuolation was the same in all the cattle, suggesting that neuronal necrosis and chromatolysis, vacuolation and hippocampal sclerosis are part of a spectrum of changes common to a single disease. The cows affected with such changes came from most parts of Scotland with the largest number from the north east. They were of various breeds, mostly suckler cows, and were aged from six to 16 years. Some cows had had no reported access to feed supplements. Clinically, the cows showed a range of neurological signs: tremor, ataxia, apprehension and weight loss were described in more than 80 per cent of the cases. The cause of the disorder was not determined.
Vet Rec 1992 Oct 17
PMID:Idiopathic brainstem neuronal chromatolysis and hippocampal sclerosis: a novel encephalopathy in clinically suspect cases of bovine spongiform encephalopathy. 891 15

A captive adult puma developed ataxia, a hypermetric gait and whole body tremor. The signs progressed over a period of six weeks. Histopathological examination following euthanasia demonstrated spongiform encephalopathy, gliosis and mild non-suppurative meningoencephalitis. Immunostaining with a polyclonal antiserum revealed prion protein (PrP) associated with these changes in sections of cervical spinal cord and medulla. This is the first confirmed case of a scrapie-like spongiform encephalopathy described in a non-domestic cat in the United Kingdom.
Vet Rec 1992 Nov 07
PMID:Spongiform encephalopathy in a captive puma (Felis concolor). 145 92

We have identified three examples of female Wistar rats exhibiting the tremor and seizures characteristic of the X-linked myelin deficiency (md) mutation, which is ordinarily seen only in males. Cytogenetic study of two of these animals has shown them to have 41 chromosomes instead of the normal 42. The missing chromosome was identified as an X chromosome by G-banding analysis. These animals thus have an XO genotype comparable to that in Turner's syndrome. Anatomically, one of the animals, which was studied in detail, showed no abnormality of the uterus, and the ovaries, although somewhat smaller than normal, were histologically indistinguishable from those in a normal female rat. No evidence of endocardial fibroelastosis was detected, nor was there any anomaly of the aorta. The myelin deficiency in the central nervous system was comparable to that in hemizygous mutant male rats. XO monosomy in the Wistar rat thus has little effect on phenotype and is more comparable to that in mice than to Turner's syndrome in man. The myelin-deficient rat is useful for studies of X-chromosome monosomy since XO females can readily be identified by the neurological syndrome characteristic of the md mutation.
Anat Rec 1990 Mar
PMID:X-chromosome monosomy in the myelin-deficient rat mutant. 232 8

Three kittens in a litter of Persian cats showed, from the age of eight weeks, tremor, ataxia, dysmetria, progressive weakness and emaciation. Cytoplasmic vacuolation was observed in neurons, mesenchymal and epithelial cells of tissues taken post mortem. The alpha-mannosidase activity of brain tissue of one cat tested was 4.8 per cent of control values and the urine of two cats contained large amounts of mannose-rich oligosaccharides.
Vet Rec 1988 Apr 09
PMID:Mannosidosis in a litter of Persian cats. 338 51

A natural infection with border disease virus occurred in a flock on low ground in Argyll in the spring of 1984. The outbreak was unusual in that the typical clinical signs of border disease, ie, tremor and, or, fleece changes were not present; manifestations of disease were restricted to abortion and the birth of small weak lambs. The disease was shown to have been introduced to the flock by four healthy ewes persistently infected with border disease virus among a group of 39 purchased in October 1983. Further investigations in late August 1984 detected viraemia in six of seven ill-thriven lambs and four of 24 apparently healthy lambs. Attempted 'natural vaccination' of susceptible sheep by mixing them at grass for three months with groups of ewes and lambs known to contain virus excretors was largely unsuccessful as only four of 22 'sentinel' sheep seroconverted. In October 1984 the persistently infected purchased animals and all that year's lamb crop were removed from the farm. No disease occurred in 1985 when the lambing percentage was 129 per cent compared with 100 per cent in 1984. Two of the four persistently infected purchased ewes were mated at Moredun Research Institute in December 1984 and both produced healthy but persistently infected lambs.
Vet Rec 1987 Mar 14
PMID:Border disease without nervous signs or fleece changes. 357 34

An account is given of a hypomyelinating condition, 'trembler', in the Bernese mountain dog. The condition is manifested clinically as a tremor of the limbs and head which becomes more intense with excitement or stress and which disappears with sleep. The tremor, which is first noticeable between two and eight weeks old, may persist throughout life but decline with age. Examination of plastic embedded tissue obtained post mortem from two, nine-week-old animals showed hypomyelination of the spinal cord. Preliminary examination of breeding data suggests that the condition may be inherited as an autosomal recessive.
Vet Rec 1987 Jun 27
PMID:Recognition of 'trembler', a hypomyelinating condition in the Bernese mountain dog. 362 70

The events which followed the introduction of a heifer into a dairy herd were consistent with the animal being persistently infected with bovine diarrhoea-mucosal disease virus. Obvious damage was limited to the progeny of cows which were in the first 168 days of gestation at that time. Only fetuses up to 81 days of gestation at the putative time of introduction of infection became persistently infected in calfhood and, although they exhibited body tremor, two such calves necropsied at three months of age lacked macroscopic or microscopic lesions in the central nervous system. In contrast calves which had been more advanced in gestation, at 146 and 153 days at the time of infection, had eliminated the infection and had lesions of cerebellar dysplasia and multifocal retinal atrophy.
Vet Rec 1986 Jan 11
PMID:Pestivirus fetopathogenicity in cattle: changing sequelae with fetal maturation. 375 9

A familial progressive muscular weakness is described in a herd of pietrain pigs. The onset of disease was at two to three weeks of age taking the form of a muscular tremor when the piglets were standing. An impaired gait followed and by 12 weeks of age the pigs had become permanently recumbent. The observed incidence of the syndrome and the breeding data available were consistent with an autosomal recessive inheritance of the condition.
Vet Rec 1980 Jun 28
PMID:A progressive, familial myopathy of the pietrain pig: the clinical syndrome. 743 27

Seven sheep flocks with subclinical psoroptic otoacariasis were investigated. Psoroptes species mites were isolated from 3.1 per cent of the 2676 sheep examined and the prevalence in the flocks ranged between 1.3 and 23.9 per cent, with the highest infestations in pedigree flocks. Unilateral or bilateral infestations were found in sheep of all ages. Adult and shearling rams, with prevalences of 21.5 and 14.2 per cent, respectively, were the most affected and two lambs, two and eight days old, were the youngest to be infested. There was no evidence of vertical transmission. The infestation affected several breeds of sheep. No other known hosts for Psoroptes species present on the premises were shown to be infested. Non-parasitic for-age mites were also isolated from the ear canals of the sheep and may have contributed to the clinical signs which, in adult sheep, ranged from aural haematomas/fibrosis (cauliflower ears), and violent head shaking and ear rubbing leading to excoriation and wounding of the ear and base of the ear. The signs in lambs included plaques of scab (often bloody) on the external ear cleft, excoriation of the base of the ear, ear scratching with the hind feet and inflammation of the external aspects of the horizontal canal. In all cases the internal pinnae were clear of typical psoroptic scabs. Psoroptes mites were isolated from 28.6 per cent of the damaged ears and from 7.8 per cent of the undamaged ears. There was no evidence of classical sheep scab in any of the flocks. Plunge dipping in diazinon, propetamphos or flumethrin, or the use of synthetic pyrethroid pour-on preparations and an oral drench of ivermectin had little effect because ear mite infestations were detected in the flocks after these treatments. An injection of ivermectin at 200 micrograms/kg bodyweight effectively eradicated the infestations when it was administered to these infested flocks.
Vet Rec 1996 Apr 20
PMID:Epidemiology of subclinical ovine psoroptic otoacariasis in Great Britain. 873 92

The use of doxapram to stimulate breathing was examined in southern elephant seals chemically restrained with ketamine and xylazine. Animals which were breathing spontaneously received doxapram (approximately 0.5, 1, 2, or 4 mg/kg) or saline into the extradural intravertebral vein. Doxapram caused a dose-dependent increase in the depth and rate of respiration which began within one minute, peaked after two minutes and lasted for up to five minutes. A dose of 2 mg/kg appeared to be safe and effective for the stimulation of respiration, while 4 mg/kg caused arousal and shaking. Doxapram (2 mg/kg) was tested on 14 occasions in animals which had developed apnoea during chemical restraint. Doxapram had no effect when administered into the extradural intravertebral vein and appeared to be of more benefit when administered directly into the lungs via an endotracheal tube, but it was not effective in all cases. There was evidence to suggest that the endotracheal tube prevented some of the animals from breathing. The effect of intubation and endotracheal doxapram administration was therefore examined in 19 apnoeic and 31 spontaneously breathing seals. Intubation induced apnoea in animals at low levels of chemical restraint and endotracheal doxapram was unreliable for the stimulation of breathing.
Vet Rec 1996 May 25
PMID:Use of the respiratory stimulant doxapram in southern elephant seals (Mirounga leonina). 876 74


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