Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0040586 (tracheobronchitis)
 449 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Case histories are analyzed of 1565 hay fever patients first attending an allergy unit. The mean age of the test persons was 19.5 years. 40% were in the age group 5 to 15 years. The sex distribution showed a slight but statistically significant prevalence of males (56.6%). 56.8% had a positive family history of allergies and 44.2% had other allergic conditions such as atopic dermatitis (31.6%), perennial rhinitis and perennial asthma (19% each), urticaria, food allergy and drug allergy (5% each) and insect sting allergy (3%). A clear cut peak both for rhinitis and for asthmatic symptoms %30.5% and 20.2% respectively) was found in the age group 5--9 years. Up to the 14th year the symptoms of pollen allergy were already exhibited by 68.5% of the patients. 97% of the pollen allergics suffered from rhinitis, 95% from conjunctivitis, 40% from bronchial asthma and another 20% from tracheobronchitis or asthmatic bronchitis. As additional symptoms of pollen allergy due to haematogenous spread of the pollen antigens we observed a seasonal form of atopic dermatitis in 3%, a seasonal urticaria or angioedema in 3.5%, migraine in 6.3% and arthralgia, gastro-intestinal troubles and fever in fewer than 1% each. Almost 98% of the patients were sensitized to grass or cereal pollens. However, only 18% suffered from an isolated grass pollinosis (summer hay fever). The other patients were additionally clinically sensitized by other pollens with different blossoming periods, i.e. 35% by three pollens responsible for the so-called spring pollinosis, and 50% by weeds (plantain, nettle, mugwort) the cause of late summer pollinosis. Only 13 patients suffered from an isolated spring pollinosis (hazel, alder, birch, willow). In 14 patients (not quite 1%) with a clear-cut history and clinical symptoms of pollinosis, all the skin tests were negative. In these cases the sensitization was probably restricted to the respiratory tract. Despite the new in-vitro methods such as the RAST, carefully performed skin tests linked to a knowledge of the pollen calendars of the region and the allergological history remain the most reliable and cheapest procedure for the specific diagnosis of pollen allergy.
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PMID:[Pollionosis: I. Findings on the clinical aspects and the pollen spectrum in 1565 pollen-sensitive patients]. 49 10

A retrospective study was performed in order to compare the clinical evolution of chronic bronchial asthma with onset in childhood with that of bronchial asthma registered at adult age. The group included 150 cases (87 females and 63 males) out of which 108 (72%) asthma with late onset and 42 (28%) asthma symptoms registered in childhood and adolescence. The symptoms were: allergic rhinitis and spastic tracheobronchitis in 18 (42.8%), dyspneic recurrent bronchitis in 16 (38%), nasal polyposis in 4 (9.5%) and atopic dermatitis in 4 (9.5%) cases. A possible allergic etiology was not taken into consideration in these cases. According to the data obtained, it results that the evolution and the prognosis of bronchial asthma are more severe in patients with its onset in childhood, where there were noted: more severe clinical forms of the disease, higher ventilation dysfunction, more numerous social (family) consequences of the disease, and a higher necessity of long term, systemic corticotherapy than in cases of bronchial asthma with late onset. The delay in the preventive treatment or an incorrect application of it in childhood will condition to a great extent the unfavourable evolution of the disease.
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PMID:[The late evolution of bronchial asthma appearing in children]. 129 96