Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0040425 (
tonsillitis
)
1,594
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Heliotropium bacciferum
(Boraginaceae) is a perennial herb, growing in the Bechar region of Algeria, where it is traditionally used for skin diseases and
tonsillitis
. Herein, we report the isolation and characterization of sixteen secondary metabolites from the aerial part extracts. They include a sterol (
1
), megastigman type nor-isoprenoids (
2
,
3
,
4
,
6
,
8
,
10
), C-11 terpene lactones (
5
and
9
), and a monoterpene (
7
) from the
chloroform
extract (HB-C); monoterpene glucoside (
14
), and phenolic compounds (
11
-
13
,
15
,
16
) from the methanol one (HB-M). Their structures were elucidated by spectroscopic methods including 1D and 2D NMR experiments, and ESIMS analysis. HB-M showed a significant and concentration dependent scavenging activity
in vitro
against the radicals DPPH and ABTS
,
related to the phenol derivatives (
11
-
13,
and
15
-
16
), and HB-C inhibited the growth of colon cancer cell lines, mainly for the presence of the antiproliferative C-11 terpene lactones (
5
and
9
).
...
PMID:
Heliotropium bacciferum
Forssk. (Boraginaceae) extracts: chemical constituents, antioxidant activity and cytotoxic effect in human cancer cell lines. 2943 Sep 49
Otostegia fruticosa
is traditionally used to treat
tonsillitis
, stomach ache, asthma, arthritis, and febrile illness in different parts of Ethiopia and other countries. In this experiment 70% ethanolic crude extract and fractions of the leaf of
Otostegia fruticosa
(Forssk.) Schweinf. ex Penzig were evaluated for their
in-vivo
anti-inflammatory and analgesic activities and
in-vitro
hyaluronidase inhibition properties at different concentrations. Tail immersion, acetic acid induced writhing and carrageenan-induced paw edema model were used to assess the
in-vivo
analgesic and anti-inflammatory activities, respectively. Swiss albino mice of either sex were randomly divided into five groups of six mice per group and for evaluation of the fractions randomly divided into six groups of six mice per group. The test groups were treated with hydroalcoholic extract of
Otostegia fruticosa (O. fruticosa)
at doses of 100, 200, and 400 mg/kg. The positive control groups received either pethidine 5 mg/kg or aspirin at 100 mg/kg or 150 mg/kg. The negative control groups were orally given sunflower oil. All the fractions were administered at the dose of 400 mg/kg. In all models, the higher dose (400 mg/kg) of the crude extract and
chloroform
fraction showed a significant central and peripheral analgesic and anti-inflammatory activities with comparable effects to standards used. The hyaluronidase inhibition assay result showed that the test samples displayed concentration-dependent inhibitory activities. These findings indicate that 70% ethanol extract and organic solvent fractions of
O. fruticosa
leaves have potential analgesic, anti-inflammatory, and enzyme inhibitory activities.
...
PMID:Analgesic, Anti-inflammatory and
In-vitro
Hyaluronidase Inhibitory Properties of the Leaf Extract and Solvent Fractions of
Otostegia Fruticosa
(Forssk.) Schweinf. ex Penzig. 3292 82
