Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0040425 (
tonsillitis
)
1,594
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The antibodies to
LTA
of Streptococcus pyogenes (S. pyogenes) and of Staphylococcus aureus (S. aureus) in sera from 110 children with or without recurrent tonsillitis were assayed by enzyme-linked immunosorbent assay (ELISA). The antibody of IgA class was not detected in any sera. There was a significant positive correlation between IgG and IgM antibody levels to
LTA
of S. pyogenes and those to
LTA
of S. aureus. There was no significant correlation between anti-
LTA
IgM antibody and age or episodes of
tonsillitis
. However, serum anti-
LTA
IgG levels in younger patients ( < or = 7 y.o.) were significantly lower than those in their elders (>7 y.o.) (anti-S. pyogenes; p = 0.0007, anti-S. aureus; p = 0.007). Serum anti-
LTA
IgG antibody levels correlated inversely with episodes of
tonsillitis
in younger patients ( < 7 y.o.) (S. pyogenes: r = -0.362, p = 0.0082, S. aureus: r = -0.276, p = 0.047). These findings suggest that systemic hyposensitivity to
LTA
of S. pyogenes and S. aureus may be a possible cause of habitualness of
tonsillitis
in young children.
...
PMID:Systemic immune response to Streptococcal and Staphylococcal lipoteichoic acids in children with recurrent tonsillitis. 908 51
